Canker sore medicine is essential for alleviating the pain and discomfort associated with these common oral lesions. In 2025, several products stand out for their effectiveness, including topical gels, mouth rinses, and natural remedies that provide quick relief and promote healing. These treatments not only soothe irritation but also help reduce inflammation and prevent infection, making them invaluable for anyone suffering from canker sores. Whether you prefer over-the-counter options or natural solutions, there is a wide range of canker sore medicines available to suit your needs.
Zilactin-B Fast Acting Canker Sore Treatment - Long Lasting Protection and Oral Pain Relief of Canker Sores, Mouth Sores and Gum Irritations, Made in USA, 0.25oz Gel, Pack of 1
- Broad-Spectrum Formula: Provides immediate, long lasting oral pain relief of canker sores, mouth sores and gum irritation
- Fast, Long-Lasting Relief: Contains a proprietary blend of ingredients including 10% Benzocaine for immediate, long lasting, oral pain relief
- Bioadhesive Technology: Provides up to 6 hours of durable protection and relief so you can eat and drink pain free
- Feel It. Heal It: Initial sting, followed by long lasting relief and recovery
- Made in USA: Assures quality and reliability in every application
$9.98
SALE
−$2.45
Orajel 3X for Mouth Sores: Maximum Strength Gel Tube 0.42oz- From #1 Oral Pain Relief Brand
- INSTANT PAIN RELIEF: Orajel Mouth Sore Gel contains 20% Benzocaine to relieve pain from canker sores, mouth sores, cold sores and other mouth irritations
- SOOTHING RELIEF: Maximum strength gel uses menthol to soothe irritated and sore gums quickly, where you need it most
- PROTECTION: Our unique, fast acting, formula contains an astringent to help protect sores from irritation, including irritation from dentures or braces, as well as canker sores
- EASY OPEN: Now with a Ready-Open Tube Tip for easy access to the relief you need. A convenient remedy for use at home or on the go.
- From the #1 Oral Pain Reliever Brand for Adults
$6.54
SALE
−$2.00
Canker-X Mouth Sore Gel, Fast Pain Relief & Healing for Canker Sores, Cheek Bites and Oral Abrasions, Oral Pain Relief Gel, Benzocaine-Free and Alcohol-Free, Adults and Kids 6+ Years, 0.28 fl oz
- FAST PAIN RELIEF & HEALING GEL: Canker-X canker sore treatment gel provides fast, long-lasting oral pain relief from canker sores, abrasions and more without any burning or numbing sensation. Clinically tested formula with NO Benzocaine and NO alcohol
- MOUTH SORES TREATMENT: Canker-X soothes canker sores, cheek bites, mouth sores and mouth abrasions often caused by braces and dentures. The alcohol-free and benzocaine-free oral pain relief gel promotes healing and relieves pain
- SOOTHES, HYDRATES & PROTECTS: The unique and clinically tested Canker-X gel formula contains Polyvinylpyrrolidone (PVP) which forms a micro-thin protective coating over a mouth sore to block irritants like food & drinks, and relieves discomfort for up to 6 hours
- HOW TO USE: Use the extended nozzle to easily apply the gel on even hard-to-reach mouth sores. You can also apply gel with a clean finger or cotton swab. Wait 2 mins for the protective barrier to form. For best results, avoid eating/drinking for 1 hour
- SAFE & EFFECTIVE: Clinically tested, Canker-X Gel is an effective canker sore treatment for both children (6+ years) and adults. Key ingredients are Aloe Vera to soothe, Sodium Hyaluronate to hydrate and Polyvinylpyrrolidone (PVP). Use as needed
$13.99
SALE
−$3.66
DenTek Canker Relief Sore Patch Relieves Canker Pain, 6 Count (Pack of 1)
- DenTek Canker Relief Advanced Canker Sore Patches help provide relief from canker sore pain and help protect from irritants while promoting healing
- Clinically tested to reduce canker sore pain and help relieve the pain from small oral wounds and irritation from braces and oral ulcers
- Flexible and ultrathin patches contain Vitamin E and help provide comfort
- Easy to use – just apply the patch to sore/wound, hold in place and patch will adhere
- Contains 1 box of DenTek Canker Relief Canker Sore Patch, 6 count
$9.89
Dentemp Canker Cover - Canker Sore Medicine Pain Reliever (8 Count) - Canker Sore Treatment to Relieve Canker Pain, Mouth Sores & Mouth Irritation - Fast Acting Canker Sore Relief Tablets for Adults
- INSTANT CANKER SORE PAIN RELIEF: Canker Cover’s mint-flavored patches provide fast relief by forming a protective barrier over canker sores inside the mouth. The soothing menthol offers immediate pain relief, promoting faster healing and protecting against mouth irritants. Speed up recovery and prevent future outbreaks with every patch.
- FAST HEALING: Dentemp Canker Cover starts healing your canker sore in as little as one day. One tablet provides 12 hours of soothing relief and stays in place, even while eating, helping to speed up recovery and promote quick healing inside the mouth.
- EXCLUSIVE VALUE SIZE: Now available in a value size with 8 tablets, only on Amazon. Enjoy more fast-acting relief, ensuring you have plenty of Canker Covers to keep your canker sores.
- EASY APPLICATION: Simply place the tablet on the sore and hold for 10 seconds. Within 30 minutes, it forms a clear, gel-like bandage that seals and protects your mouth sore for hours, dissolving gradually for long-lasting relief. Get relief that sticks from Dentemp.
- OUR PROMISE – 40+ YEARS OF CONFIDENCE: For over 40 years, Dentemp has helped people smile confidently with products like dental cement, denture repair, oral pain relief, and anti-snoring solutions. We’re committed to innovation, making oral care easy, affordable, and effective while bringing dentist-level technology into your home. We also prioritize sustainability in everything we do.
$13.29
Durham's Bee Farm, Inc. Canker-Rid® - Get Immediate Relief and Heal Canker Sores - Restore Your Quality of Life Today
- Effective canker sore treatment
- Immediate relief of pain
- Canker-rid? – Get immediate relief and heal canker sores – Restore Your Quality Of Life today – Guaranteed; By durham' S Bee Farm, Inc
- Canker-rid? – Get immediate relief and heal canker sores – Restore Your Quality Of Life today – Guaranteed; By durham' S Bee Farm, Inc
$21.95
SALE
−$1.25
Anbesol Maximum Strength Oral Pain Relief Gel, Instant Pain Relief For Toothache Pain, Canker Sores, Sore Gums, Mouth Sores, Denture Pain, and Aligner Pain, ADA Accepted, 0.33 oz (packaging may vary)
- INSTANT PAIN RELIEF: Instant oral pain relief for mouth and gum irritation due to toothaches, canker sores, sore gums, denture pain, and minor dental procedures. Use with dentures to relieve discomfort.
- MAXIMUM STRENGTH: Instant relief that takes you from ouch to ahhh! So, oral pain doesn’t hold you back. Formulated with 20% Benzocaine to offer maximum strength pain relief and instantly soothe mouth pain and dental irritation
- EASY TO USE: Cut the Tube Tip for easy access to the oral pain relief you need; Adults and children 2 years and over. Not for use in children under 2 years of age.
- ACTIVE INGREDIENT: Benzocaine 20% Oral anesthetic for pain relief.
$6.74
SALE
−$3.58
Boiron Borax 6C Homeopathic Medicine for Canker Sore Relief, Pain, Soreness, or Discomfort - 3 Count (240 Pellets)
- Suitable for adults and children with oral discomfort caused by dentures, braces, or canker sores.
- Easy to take — no food or water needed.
- No known interactions with other medications, herbs, or supplements.
- No artificial sweeteners, flavors, colors, or preservatives.
- Available over the counter; HSA & FSA eligible.
$11.70
Last update on 2025-05-04 / Affiliate links / Images from Amazon Product Advertising API