Over the counter heartburn medicine offers effective relief for those suffering from acid reflux and heartburn symptoms. In 2025, several options stand out for their efficacy and user satisfaction. Popular choices include antacids like Tums and Rolaids, which provide quick relief, as well as H2 blockers such as Zantac and Pepcid, which reduce stomach acid production. Proton pump inhibitors like Prilosec and Nexium are also favored for their long-lasting effects. Other notable mentions include Gaviscon, which forms a protective barrier, and Alka-Seltzer, known for its fast-acting formula. With a variety of formulations available, individuals can find the right over the counter heartburn medicine to suit their needs.
SALE
−$4.96
Amazon Basic Care Omeprazole Delayed Release Tablets 20 mg, Treats Frequent Heartburn, Acid Reducer, Heartburn Medicine, 42 Count (Pack of 1) (Packaging may vary)
- ACTIVE INGREDIENT: The active ingredient in these delayed release tablets is omeprazole 20 mg, which works as an acid reducer to treat frequent heartburn. Compare to Prilosec OTC
- TREATS FREQUENT HEARTBURN: Amazon Basic Care Omeprazole Delayed Release Tablets 20 mg treat frequent heartburn that occurs 2 or more times a week
- ACID REDUCER: Amazon Basic Care Omeprazole Delayed Release Tablets 20 mg is a Proton Pump Inhibitor (PPI) that deactivates pumps in the stomach lining to inhibit acid production at the source.
- 14-DAY COURSE OF HEARTBURN TREATMENT: Taken once every 24 hours for 14 days, Amazon Basic Care Omeprazole Delayed Release Tablets 20 mg is not intended for immediate relief of heartburn and may take 1 to 4 days for full effect.
- HEARTBURN TIPS: Do not eat late at night or just before bedtime. Certain foods or drinks are more likely to cause heartburn, such as rich, spicy, fatty and fried foods, chocolate, caffeine, alcohol and even some fruits and vegetables.
$10.84
SALE
−$3.22
Amazon Basic Care Esomeprazole Magnesium Delayed Release Capsules, 20 mg, Acid Reducer, Heartburn Medicine, 42 Count
- EFFECTIVE: Active ingredient in Amazon Basic Care Esomeprazole Magnesium Delayed Release Capsules, esomeprazole, 20 mg, acid reducer; compare to the active ingredient in Nexium 24 HR
- ACID REDUCER: Inhibits acid production at the source; enjoy foods and beverages that could cause frequent heartburn
- PROVEN HEARTBURN TREATMENT: Clinically proven to treat frequent heartburn that occurs 2 or more days a week
- HEARTBURN TREATMENT: Take once every 24 hours for 14 days; this heartburn medicine may take 1 to 4 days for full effect
- GLUTEN FREE: Amazon Basic Care Esomeprazole Magnesium Delayed Release Capsules, 20 mg; gluten free
$12.50
SALE
−$1.26
Amazon Basic Care Maximum Strength Famotidine Tablets 20 mg, Acid Reducer Pills for Heartburn Relief, 200 Count (Packaging may vary)
- ACTIVE INGREDIENT: This product contains 20 mg of famotidine, an acid reducer for heartburn relief, which compares to the active ingredient in Maximum Strength Pepcid AC.
- RELIEVES HEARTBURN: Amazon Basic Care Maximum Strength Famotidine Tablets 20 mg help to relieve heartburn due to acid indigestion and sour stomach. PREVENTS
- HEARTBURN: Taken 10 to 60 minutes ahead of time, Amazon Basic Care Famotidine Tablets 20 mg prevents heartburn due to acid indigestion brought on by eating and drinking certain foods and beverages. JUST
- ONE TABLET prevents and relieves heartburn due to acid indigestion brought on by eating and drinking certain foods and beverages. This heartburn medicine lasts up to 12 hours. Use for adults & children 12 years and over. This product is gluten free.
- HEARTBURN MEDICINE: The active ingredient in Amazon Basic Care Famotidine Tablets 20 mg is an H2-blocker, which works as an acid reducer to help relieve heartburn. Lasts up to 12 hours. Use for adults and children 12 years and over.
$10.91
HealthCareAisle Omeprazole 20 mg, 42 Delayed-Release Capsules - Acid Reducer, Treats Frequent Heartburn, 42 Count (Pack of 1)
- EFFECTIVE HEARTBURN RELIEF: Omeprazole acid reducer capsule that treats frequent heartburn occurring 2 or more days a week.
- 14-DAY ACID REFLUX MEDICINE:Take one Omeprazole capsule daily for heartburn relief up to 24 hours. May take 1-4 days for full effect. See package label for warnings and other important information.
- COMPARABLE TO THE NATIONAL BRAND: Has the same active ingredient as Prilosec OTC*
- STOP HEARTBURN AT THE SOURCE: Our Omeprazole 20mg capsules inbibit the proton pumps in the stomach from producing excess acid, acting as an acid reducer.
- Directions: use as directed for 14 days; do not take for more than 14 days or more often than every 4 months unless directed by your healthcare provider
$11.21
TUMS Chewy Bites Antacid Tablets for Chewable Heartburn Relief and Acid Indigestion Relief, Assorted Berries - 60 Count
- Comes in a container
- Reduces stomach acid
- Take two or three
- Instantly neutralizes acid
- Take on the go
$9.98
Glenmark Maximum Strength Famotidine Tablets, 20 mg, Acid Reducer for Heartburn Relief, 200 Count
- ACTIVE INGREDIENT: This item’s formula includes 20 mg of Famotidine, which is an acid reducer for heartburn relief.
- EFFECTIVE: Acid Reducers like Famotidine Tablets, 20 mg can prevent and relieve heartburn due to sour stomach and acid indigestion. Only one tablet relieves and prevents heartburn due to acid indigestion.
- WHAT IS HEARTBURN? Heartburn occurs when stomach contents flow back up into the esophagus—the muscular tube that carries food and liquids from the mouth to the stomach. A heartburn medicine like Famotidine Tablets,20 mg helps provide heartburn relief.
- MANAGING HEARTBURN: Tips for managing heartburn include: Do not lie flat or bend over after eating, Do not wear tight-fitting clothing around the stomach, Do not eat before bedtime, Raise the head of your bed, Avoid heartburn-causing foods such as rich, spicy, fatty or fried foods, chocolate, caffeine, alcohol, and certain fruits and vegetables Eat slowly and avoid big meals If overweight, lose weight Quit smoking
- TYPES OF HEARTBURN MEDICINE: This product is an H2 blocker and it works to reduce acid in an attempt to relieve mild heartburn or indigestion. Lasts 12 hours.
$8.99
SALE
−$1.49
GoodSense Omeprazole Delayed Release Tablets 20 mg, Stomach Acid Reducer for Frequent Heartburn Treatment, 42 Count
- ACTIVE INGREDIENT: The active ingredient in these delayed release tablets is omeprazole 20 mg, which works as an acid reducer to treat frequent heartburn. Compare to Prilosec OTC
- TREATS FREQUENT HEARTBURN: GoodSense Omeprazole Delayed Release Tablets 20 mg treat frequent heartburn that occurs 2 or more times a week
- ACID REDUCER: GoodSense Omeprazole Delayed Release Tablets 20 mg is a Proton Pump Inhibitor (PPI) that deactivates pumps in the stomach lining to inhibit acid production at the source.
- 14-DAY COURSE OF HEARTBURN TREATMENT: Taken once every 24 hours for 14 days, GoodSense Omeprazole Delayed Release Tablets 20 mg is not intended for immediate relief of heartburn and may take 1 to 4 days for full effect.
- FREQUENT HEARTBURN FROM GLP-1? Try GoodSense Esomeprazole and continue on your weight loss journey. Use as directed. Not for immediate relief.
$14.50
SALE
−$0.76
Amazon Basic Care Heartburn & Gas SuperChews Chewable Tablets, Mixed Berry, 82 Count (Previously SoundHealth)
- Chewy Not Chalky: Fast-acting relief for heartburn, gas, sour stomach, and bloating from 750 mg of calcium carbonate and 80 mg of Simethicone in an enjoyable product form
- Full of Flavor: Delicious mixed berry flavors are easily accessible in an easy-to-open flip cap bottle. Adults and children 12 years and up can take 1-2 chewable tablets every 2-4 hours as needed.
- Same Benefits, Lower Cost: Amazon Basic Care Antacid Fruit Chews are formulated to include the same active ingredients and provide the same relief as the name brand, but at a lower price to consumers
- This product was previously a SoundHealth product. Now it’s a part of the Amazon Basic Care Brand, the product is the exact same formulations, size, and quality.
- An Amazon Brand
$9.09
Last update on 2025-05-03 / Affiliate links / Images from Amazon Product Advertising API