Cold and flu medicine is essential for alleviating the discomfort associated with seasonal illnesses. In 2025, the market offers a variety of effective options that cater to different symptoms, from congestion and cough to fever and body aches. These medicines often combine multiple active ingredients to provide comprehensive relief, making it easier for individuals to manage their symptoms and recover more quickly. Whether you prefer over-the-counter solutions or natural remedies, there are numerous choices available to help you feel better during cold and flu season.
SALE
−$2.52
Alka-Seltzer Plus Severe, Cold & Flu Medicine, Citrus Effervescent Tablets, Nasal & Sinus Congestion, Sneezing, Runny Nose, Cough, Sore Throat 24 Count, Packaging May Vary
- Our fantastic formula made even better: improved flavor, less sodium, & aspartame free
- Our severe Cold & Flu medicine formula provides unbeatably liquid fast relief of headache, sore throat, cough, nasal & sinus congestion, runny nose, sneezing, aches & pains and fever.
- Quickly dissolves in water and instantly ready to start working so you can get back to your busy life.
- Each box containing 10 Sachets each containing 1 individually wrapped dose (2 effervescent tablets), which makes it easy to take with you on the go
- Comes in Effervescent form, in a refreshing Citrus flavor. Use as directed.
$9.47
VICKS DayQuil & NyQuil High Blood Pressure Cold & Flu Relief Liquicap 48ct Co-Pack, Powerful Multi Symptom Daytime & Nighttime Medicine for Cold, Cough, and Flu Symptoms, 24ct DayQuil, 24ct NyQuil
- SPECIALLY FORMULATED COLD & FLU RELIEF FOR PEOPLE WITH HIGH BLOOD PRESSURE: High blood pressure means some medicines are off limits. Not DayQuil and NyQuil HBP! They are specially formulated to be decongestant-free
- POWERFUL MULTI-SYMPTOM RELIEF: Use non-drowsy DayQuil for daytime relief, and at night try NyQuil for fast relief so you can get the rest you need
- EFFECTIVE COLD & FLU SYMPTOM RELIEF: DayQuil and NyQuil High Blood Pressure Cold & Flu Liquicaps temporarily relieve common cold & flu symptoms. Just one dose starts working fast to provide effective cold & flu relief
- POWER THROUGH YOUR WORST COLD & FLU SYMPTOMS: Life doesn't stop when you have a cold. DayQuil and NyQuil relieve bothersome symptoms, such as cough and fever, day or night
- EASY TO SWALLOW LIQUICAPS: DayQuil and NyQuil High Blood Pressure Liquicaps are 25% smaller than original DayQuil and NyQuil Liquicaps
$19.99
VICKS DayQuil & NyQuil High Blood Pressure Cold & Flu Relief Liquid Medicine Co-Pack, Powerful Multi-Symptom Daytime & Nighttime Relief for Cold, Cough, and Flu Symptoms, Sugar & Alcohol Free, 2x8oz
- SPECIALLY FORMULATED COLD & FLU RELIEF FOR PEOPLE WITH HIGH BLOOD PRESSURE. High blood pressure means some medicines are off limits. Not these! Specially formulated to be decongestant, sugar, and alcohol free.
- FAST, POWERFUL MULTI-SYMPTOM RELIEF. Use non-drowsy DayQuil for daytime relief and at night try NyQuil for fast relief so you can rest.
- EFFECTIVE COLD & FLU SYMPTOM RELIEF. DayQuil and NyQuil Cold & Flu medicine temporarily relieve common cold & flu symptoms. Just one dose starts working fast to provide effective cold & flu relief
- POWER THROUGH YOUR WORST COLD & FLU SYMPTOMS. Life doesn’t stop when you have a cold. DayQuil and NyQuil relieve bothersome symptoms, such as cough and fever, day or night.
- WORLD'S #1 SELLING OTC COUGH AND COLD BRAND. Vicks has been trusted for over 125 years to relieve your worst cold & flu symptoms.
$16.59
Amazon Basic Care Vapor Ice Day and Night Severe Cold and Flu Relief Caplets, Maximum Strength Medicine, Combo Pack, 48 Count
- ACTIVE INGREDIENTS: Amazon Basic Care Vapor Ice Daytime and Nighttime Severe Cold and Flu help to relieve common cold and flu symptoms, day and night; compare to the active ingredients in Vicks DayQuil and NyQuil Severe VapoCOOL
- EFFECTIVE: Daytime relieves minor aches and pains, fever, nasal congestion, sinus pressure, cough and chest congestion; Nighttime relieves minor aches and pains, fever, nasal congestion, sinus pressure, sneezing, runny nose and cough
- COMBINATION PACK: Amazon Basic Care Vapor Ice Daytime and Nighttime Severe Cold and Flu comes in a combination pack for around-the-clock maximum strength, multi-symptom relief for your worst cold and flu symptoms
- COATED CAPLETS: Contain pain reliever/fever reducer, cough suppressant, nasal decongestant, antihistamine, expectorant (antihistamine in nighttime only, expectorant in daytime only)
- MAXIMUM STRENGTH: Get day and night cold and flu relief with these max strength coated caplets. Relieve sore throat and other cold and flu symptoms with Amazon Basic Care Vapor Ice Daytime and Nighttime Severe Cold and Flu
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VICKS DayQuil & NyQuil SEVERE Honey Flavor Co-Pack, Cold & Flu Medicine, RelievesHeadache, Fever, Sore Throat, Minor Aches & Pains, Nasal Congestion, Sinus Pressure, Stuffy Nose, and Cough, 2x12oz
- GREAT-TASTING HONEY FLAVORED DAYQUIL AND NYQUIL: Get the same cold & flu relief you expect from DayQuil & NyQuil SEVERE in a great-tasting honey-licious flavor
- POWERFUL, MAXIMUM STRENGTH 9-SYMPTOM RELIEF DAY AND NIGHT: Use non-drowsy DayQuil SEVERE Honey for daytime and at night try NyQuil SEVERE Honey for fast relief so you can rest
- POWERFUL COLD & FLU RELIEF: DayQuil and NyQuil SEVERE Honey formulas are flavored with real honey & temporarily relieve common cold & flu symptoms
- PROVEN RELIEF FOR YOUR WORST COLD & FLU SYMPTOMS: Life doesn't stop when you have a cold; NyQuil and DayQuil SEVERE Honey tackle your most bothersome cold & flu symptoms
- WORLD'S TOP SELLING OTC COUGH AND COLD BRAND: Vicks has been trusted for over 125 years to relieve your worst cold & flu symptoms
$19.97
SALE
−$1.02
Alka-Seltzer Plus Power Max Cold and Flu Medicine, Day+Night, - Maximum Strength (Per 4 Hour Dose) Relief Cold and Flu Medicine for Adults and Children 12 Years and Older, 24 Count, Packaging May Vary
- Alka-Seltzer Plus Power Max Cold and Flu Medicine is designed for cold and flu symptoms and provides timely relief *Use as directed.
- One dose provides 4 hour day time or night time cold and flu relief of cough, nasal congestion, fever, sinus congestion, headache & body ache, sore throat, and sinus pressure
- Cold and flu medicine for adults and children 12 years and older that contains a pain reliever, fever reducer, cough suppressant, antihistamine (night time only), and nasal decongestant
- Temporarily relieves these symptoms due to cold and flu: Minor aches and pains, cough, headache, sore throat, nasal and sinus congestion, runny nose, & sneezing (runny nose & sneezing apply to night time dosage only).
- The medicine contains a powerful combination of active ingredients, including dextromethorphan, that helps relieve cough.
$9.47
Amazon Basic Care Daytime and Nighttime Cold and Flu Relief Syrup Combo Pack, Powerful Liquid Flu and Cold Medicine for Day and Night, Gluten Free, Original & Cherry, 12 fl oz (Pack of 4)
- The information below is per-pack only
- ACTIVE INGREDIENTS: Compare this cold and flu medicine combination pack to the active ingredients in Vicks DayQuil Cold & Flu and Vicks NyQuil Cold & Flu
- MULTI-SYMPTOM RELIEF: Daytime and Nighttime cold medicine provides powerful relief of cold and flu symptoms so you can cope during the day and rest at night
- DAYTIME COLD AND FLU relieves aches, fever, sore throat, nasal congestion and cough. Daytime cold medicine provides powerful relief so you can cope and is also alcohol and antihistamine free
- NIGHTTIME COLD AND FLU relieves aches, fever, sore throat, sneezing, runny nose and cough. This Nighttime cold medicine provides maximum strength relief for cold and flu-like symptoms so you can rest
$24.54
Amazon Basic Care Cold and Flu Relief, Daytime and Nighttime Combo Pack Softgels, Powerful Cold Medicine for Day and Night Multi-Symptom Relief, 48 Count(Pack of 1)
- ACTIVE INGREDIENTS: Compare to the active ingredients in Vicks DayQuil Cold & Flu and Vicks NyQuil Cold & Flu
- NON-DROWSY DAYTIME COLD AND FLU MEDICINE provides multi-symptom relief of headache, fever, sore throat, nasal congestion, cough, and minor aches and pains
- NIGHTTIME COLD AND FLU MEDICINE provides multi-symptom relief of headache, fever, sore throat, sneezing, runny nose, cough, and minor aches and pains
- PAIN RELIEVER AND FEVER REDUCER: Both Daytime and Nighttime cold medicine contain acetaminophen to help relieve aches, fever and sore throat
- COLD AND FLU: Influenza (flu) and the common cold are respiratory illnesses caused by viruses. A cold medicine like Cold & Flu Relief Multi-Symptom Daytime/Nighttime can help
$10.49
SALE
−$4.22
Children's TYLENOL Cold + Flu Oral Suspension, Grape, 4 Fl. Oz
- 4-fluid ounces of Children's Tylenol Oral Suspension Liquid Medicine with grape flavor to temporarily relieve kids' cold & flu symptoms, including cough, headache and fever
- This multi-symptom relief medicine for kids also helps relieve minor aches and pains, sore throat, stuffy or runny nose, sneezing and congestion
- Each 5mL contains 160 mg of acetaminophen pain reliever and fever reducer, 5 mg of dextromethorphan HBr cough suppressant, 2.5 mg of phenylephrine HCl decongestant and 1 mg of the antihistamine chlorpheniramine maleate
- Indicated for children ages 6 to 11 years, this kids cold and flu medicine comes in a kid-friendly grape flavor with a formula that is free of aspirin, alcohol and ibuprofen
- Tylenol is the #1 pediatrician recommended brand for pain & fever relief and has been relied on by parents for over 60 years.
$6.48
Amazon Basic Care Tussin Severe CF Max Syrup, Multi-Symptom Cough, Cold and Flu Liquid Medicine, Non-Drowsy, Relieves Cough, Sore Throat, Body Aches, Fever, Nasal and Chest Congestion, 8 fl oz
- ACTIVE INGREDIENTS: This cold medicine contains a pain reliever/fever reducer, cough suppressant, expectorant and nasal decongestant. Compare to the active ingredients in Robitussin Severe Multi-Symptom Cough Cold + Flu.
- MAXIMUM STRENGTH: This cold medicine provides maximum strength relief of multiple cold and flu symptoms such as cough, nasal congestion, sinus congestion and pressure, minor aches and pains, sore throat, headache and temporarily reduces fever.
- MUCUS RELIEF: Take this cold medicine to help loosen phlegm (mucus) and thin bronchial secretions to drain bronchial tubes and make coughs more productive.
- NON-DROWSY: This non-drowsy cold and flu medicine provides relief for adults and children age 12 years and over. Dosage cup included.
- GREAT TASTING COLD MEDICINE: Amazon Basic Care Tussin CF Max, Multiple Symptom Cough Cold & Flu is gluten free, sugar free and alcohol free. Maximum strength claim based on maximum levels of active ingredients per 4 hour dose.
$5.01
Last update on 2025-05-02 / Affiliate links / Images from Amazon Product Advertising API