Sinus drainage can be a frustrating issue, but finding the right medicine can provide significant relief. The best medicine for sinus drainage includes a variety of options such as decongestants, antihistamines, and nasal sprays that help alleviate symptoms and promote better airflow. These medications work by reducing inflammation, thinning mucus, and clearing nasal passages, making it easier to breathe. Whether you prefer over-the-counter solutions or prescription options, there are effective treatments available to help you manage sinus drainage effectively.
Sudafed PE Head Congestion + Mucus Tablets for Sinus Pressure, Pain & Congestion, 24 ct
- 24-count box of Sudafed PE Head Congestion + Mucus Tablets to provide non-drowsy relief from sinus pain and pressure, nasal & chest congestion, and excess mucus
- Sinus relief medicine contains 5 mg of phenylephrine HCl, a decongestant, for congestion relief and 325 mg of acetaminophen for pain and fever reduction. Also has 200 mg of guaifenesin, an expectorant, for mucus reduction
- Head congestion tablets temporary relieves symptoms associated with hay fever, upper respiratory allergies, and the common cold
- Non-drowsy decongestant tablets provide relief of sinus pressure, headaches, nasal and chest congestion, excess mucus, and minor aches and pains
- Head congestion relief medicine also helps loosen mucus to clear bronchial passageways and make coughs more productive. Get powerful head congestion relief from the pharmacist recommended brand among oral OTC decongestants.
$10.99
SALE
−$3.02
Mucinex Sinus-Max Severe Congestion Relief Caplets, 20 Count
- MAXIMUM STRENGTH RELIEF: Maximum Strength Mucinex Sinus-Max Severe Congestion & Pain helps relieve pain, headache, nasal congestion, sinus congestion and chest congestion.
- #1 TRUSTED COLD AND COUGH BRAND: #1 Cold and Cough brand doctors trust*
- PAIN RELIEVER: Contains Acetaminophen which relieves minor aches and pains
- EXPECTORANT: Contains Guaifenesin that thins and loosens mucus; relieves chest congestion
- NASAL DECONGESTANT: Contains Phenylephrine HCl that provides relief for nasal congestion, sinus congestion and pressure
$10.97
SALE
−$0.50
Boiron SinusCalm Tablets for Sinus Pain Relief, Runny Nose, Congestion, Sinus Pressure, Headache - 60 Count
- Targets sinus pain with a stuffy or runny nose.
- Non-drowsy and won't mask symptoms of a more serious condition
- Homeopathic multi-symptom sinus Relief medicine, non-habit forming and no risk of a rebound effect
- Slightly sweet pellets melt under the tongue without water, chewing, or swallowing pills. Pellets can also be dissolved in water for children or seniors. Recommended for everyone ages 6 and up.
- Available over the counter in a box of two multidose tubes for home or on the go (approximately 80 oral pellets per tube)
$10.49
SALE
−$2.68
Sudafed PE Sinus Pressure + Pain Relief Tablets, Maximum Strength, Non-Drowsy, OTC Sinus Relief Medicine with Acetaminophen Pain Reliever & Phenylephrine HCl Nasal Decongestant, 24 ct
- DECONGESTANT & PAIN RELIEF: 24-count package of Sudafed PE Sinus Pressure and Pain maximum strength non-drowsy decongestant tablets for fast and powerful relief of sinus congestion, sinus pressure, and nasal congestion
- NON-DROWSY COLD & SINUS MEDICINE: Sudafed sinus and pain medication helps to temporarily relieve nasal congestion associated with hay fever, upper respiratory allergies and the common cold, plus, helps relieve sinus pressure and sinus headaches
- PHENYLEPHRINE & ACETAMINOPHEN: Each sinus congestion and pressure relief tablet contains 5 mg of phenylephrine HCI, a nasal decongestant that provides non-drowsy relief, plus, 325 mg of acetaminophen, a pain and fever reducer
- HOW TO USE: Sudafed PE sinus pressure and pain relief congestion relief tablets can be used by adults and children ages 12 and up. Take two tablets every four hours; do not exceed 10 tablets within a 24 hour time period
- FSA HSA APPROVED PRODUCT: Sinus congestion relief and pain medicine from Sudafed, the #1 pharmacist recommended brand among oral OTC decongestants. Sudafed PE Sinus Pressure + Pain is HSA & FSA eligible. Product eligibility may vary by plan
$7.99
SALE
−$3.03
Tylenol Sinus Severe Daytime Cold & Flu Relief Medicine Caplets, Non-Drowsy Pain Reliever, Fever Reducer Expectorant & Decongestant, Acetaminophen, Guaifenesin & Phenylephrine HCl, 24 ct
- 24-count of Tylenol Sinus Severe Daytime Medicine Caplets for non-drowsy relief of symptoms due to the common cold, flu, hay fever or other respiratory allergies such as mucus and sinus congestion
- Pain reliever, fever reducer, decongestant and expectorant medicine temporarily relieves minor aches and pains as well as symptoms of chest congestion, nasal congestion, sinus headache and pressure
- Each caplet contains 325 milligrams of acetaminophen to reduce fever and pain; 5 milligrams of nasal decongestant phenylephrine HCl to help clear nasal passages; and 200 milligrams of the expectorant guaifenesin to help make coughs more productive
- The non-drowsy formula of this sinus decongestant medicine provides effective daytime symptom relief by promoting sinus drainage, decongesting sinus openings and passages, and thinning bronchial secretions to help make coughs more productive
- From the #1 doctor recommended pain relief brand, these severe sinus relief caplets are suitable for adults and children ages 12 years and older for powerful daytime cold symptom relief
$7.64
SALE
−$4.11
Rite Aid Maximum Strength Daytime and Nighttime Sinus Relief Caplets - 20 Count | Sinus & Cold Medicine | Cough & Cold Medicine | Cold Medicine for Adults | Sinus Pressure & Tension Headache Relief
- DAY/NIGHT COMBO PACK: This Rite Aid Sinus Relief cold medicine for adults includes non-drowsy daytime and nighttime sinus relief medicine. This combo pack relieves your symptoms so you can get through the day without drowsiness and sleep at night.
- MULTI-SYMPTOM RELIEF: You’ll feel daytime relief from sinus pressure, headache, and congestion in a non-drowsy formula. And at night, your nasal congestion, sinus pressure, pain, runny nose, sneezing, and cough will be relieved so you can sleep.
- FEVER & PAIN RELIEVER: Acetaminophen 325mg in each caplet temporally relieves symptoms like minor aches and pains and headache— while expectorant, nasal decongestant, antihistamine/cough suppressant, and nasal decongestant offer sinus pressure relief.
- FOR YOUR SEVERE SYMPTOMS: With Rite Aid Maximum Strength Sinus Relief cold medicine, you’ll get a pain reliever, expectorant to power through mucus, nasal decongestant for sinus congestion and pressure, antihistamine/cough suppressant to calm your cough.
- TRUSTED BRAND SINCE 1962: We hope you continue to choose Rite Aid first for your everyday health and wellness needs. Our mission is to improve the health and wellness of our communities and provide our customers with the best products, services, and advice.
$3.88
SALE
−$2.88
Tylenol Sinus + Headache Daytime Non-Drowsy Relief Caplets, Acetaminophen 325mg, Nasal Decongestant for Sinus Pressure, Headache & Nasal Congestion Relief, 24 ct
- 24-count box of Tylenol Sinus + Headache Daytime Caplets for non-drowsy sinus symptom and headache pain relief due to the common cold, hay fever or other respiratory allergies
- Pain reliever and nasal decongestant formulated to temporarily reduce fever and relieve symptoms of nasal congestion, sinus headache and pressure
- Each sinus relief caplet contains 325 milligrams of acetaminophen to temporarily relieve pain and reduce fever as well as 5 milligrams of phenylephrine HCl, a nasal decongestant to help clear nasal passages
- The non-drowsy formula of this sinus medicine provides effective daytime symptom relief by promoting sinus drainage and helping to decongest sinus openings and passages
- From the #1 doctor recommended pain relief brand, these daytime headache and sinus relief caplets are suitable for adults and children ages 12 years and older for powerful daytime cold symptom relief
$7.79
Vicks Sinex SEVERE, All-In-One Sinus + Mucus Relief, Non-Drowsy, Loosens Mucus, Maximum Strength Relief of Pain, Pressure, Congestion, & Headache Relief, 24 LiquiCaps
- Experience fast, powerful relief from nasal congestion, sinus pressure, sinus headache, sinus pain, chest congestion and mucus!
- Best suited to treat sinus symptoms caused by the common cold, hay fever, or other upper respiratory allergies because it thins and loosens mucus, reduces pressure in the sinuses, and relieves sinus pain!
- The powerful, non-drowsy nasal decongestant medicine, expectorant, and pain reliever help to provide all in one relief for your sinus symptoms!
- HSA and FSA eligible, Check with your provider for more details
- This product is not formulated with an antihistimine allergy medicine and is not intended to treat runny nose, itchy & watery eyes, or sneezing
$8.84
SALE
−$1.02
Alka-Seltzer Plus Maximum Strength Power Max Sinus, Allergy and Cough Medicine for Adults and Children 12 Years and Older - Relieves Symptoms from Allergies, Colds or Hay Fever, 24 Count
- Alka-Seltzer Plus Maximum Strength Powermax gels provide powerful allergy and sinus relief *Use as directed.
- Get the fast, effective relief from colds, hay fever, and allergy symptoms when you need it.
- ASP Sinus, Allergy & Cough medicine contains a pain reliever / fever reducer, cough suppressant, antihistamine and a nasal decongestant.
- This sinus, allergy, and cough medicine contains an antihistamine which helps to reduce allergy symptoms like sneezing, runny nose, and itchy/watery eyes.
- This Sinus, Allergy & Cough relief medicine also contains cough suppressant and nasal decongestant to help relieve cough, nasal congestion, sinus congestion and pressure.
$9.47
Bionaze Oral Probiotic K12 & BL-04 for Sinus, Tonsil Stones, Bad Breath, Post Nasal Drip, Throat, Mouth, Teeth & Gut - Improve Oral & Respiratory Health. Clinically Proven Probiotic Strains 30 ct
- BACKED BY SCIENCE - BLIS K12 and BL-04 have been shown to produce effective results against bad bacteria in the mouth, ear, nose, throat and sinus.
- PROMOTES A HEALTHY MOUTH - Our specially formulated oral probiotic introduces good bacteria to your mouth to fight chronic bad breath and support healthy gums.
- RESPIRATORY SUPPORT - BLIS K12 is a potent bacteria strain which can also promote the overall defenses in the chest and head area.
- ADVANCED PROTECTION - Oral health is vital to your overall well-being. With just 2 dental probiotics per day you can battle common occurring problems with teeth, gums, and breath.
- SATISFACTION GUARANTEED - Every purchase is fully backed by our top-notch staff who is empowered to make sure you're happy. All capsules are proudly Made in USA.
$21.99
Last update on 2025-06-01 / Affiliate links / Images from Amazon Product Advertising API