Best spray for bed bugs are essential tools in the battle against these persistent pests. In 2025, a variety of effective sprays have emerged, each designed to target bed bugs at different life stages, ensuring comprehensive eradication. From natural ingredients to potent chemical formulations, these sprays offer various options for homeowners seeking relief from infestations. When selecting the right product, consider factors such as safety, ease of use, and effectiveness to ensure a pest-free environment.
SALE
−$3.02
Ortho Home Defense Max Bed Bug, Flea and Tick Killer with Comfort Wand, Bed Bug Spray, Kills Bed Bug Eggs, Fleas and Ticks, 1 gal.
- Kill bed bugs, bed bug eggs, fleas and ticks with Ortho Home Defense Max Bed Bug, Flea & Tick Killer
- This bed bug spray kills even the toughest bed bugs (pyrethroid-resistant bed bugs)
- Use this indoor bug killer as a spot treatment around bed frames, baseboards and mattress seams, tufts and folds
- Apply insect spray using the included Comfort Wand to target tight and hard-to-reach places where bed bugs hide
- Ortho Home Defense Max Bed Bug, Flea & Tick Killer is a Step 2 product in the Ortho Bed Bug Solution System; use with Step 1: Detect and Trap and Step 3: Cracks and Crevices products for best results
$19.97
Bed Bug Killer 16 oz EcoVenger by EcoRaider, 100% Kill Efficacy, Bedbugs & Mites, Kills Eggs & The Resistant, Lasting Protection, USDA BIO-Certified, Plant Extract Based & Non-Toxic, Child & Pet Safe
- PROVEN THROUGH USDA IR4 PHP PROGRAM — field tested by research entomologists for eradicating bed bug infestations in public housing buildings and recommended for sensitive environment
- KILL ALL STAGES INCLUSIVE & EVEN RESISTANT BED BUGS — Kills bed bug adults and nymphs fast on contact with 100% efficacy, kills bed bugs that are resistant to traditional pesticides. Proven highest performance in eliminating bed bug eggs
- EXTENDED DRY RESIDUAL PROTECTION — University study shows EcoRaider residual provides extended protection for two weeks on bed bugs even after dried
- NON-TOXIC, SAFE AND ECO-FRIENDLY — certified USDA BioBased insecticide, dermatologically safe; child and pet friendly; safe to use directly on mattress and box springs.
- INGREDIENTS: Geraniol, Cedarwood oil, Sodium Lauryl Sulfate, Glyceryl dicaprylate, Silica hydrate, Glyceryl monooleate and water.
$19.45
Hot Shot Bed Bug Killer Aerosol, Bed Bug Treatment, 17.5 oz
- This product kills bed bugs and bed bug eggs, as well as crawling insects, brown dog ticks, fleas, dust mites, clothes moths and carpet beetles. Use as part of a bed bug treatment
- For use on mattresses, wood furniture and carpet. This product can also be used on bed frames, headboards, floors, moldings, ceiling and walls
- Controls bed bugs for up to 3 weeks on carpeted surfaces
- Non-staining, no unpleasant odor
$7.84
SALE
−$0.73
Raid Bed Bug Foaming Spray, Kills Bed Bugs and Their Eggs, for Indoor Use, Non-Staining, Keeps Killing for Weeks, 16.5 oz (Pack of 1)
- Kills bed bugs and their eggs on contact
- Kills bed bugs on surfaces for up to 4 weeks
- Foam expands into hard to reach indoor places, and is easy to see where you sprayed
- Scientifically formulated to kill Pyrethroid-resistant Bed Bug strains
- Money Back Guarantee
$10.25
Harris Toughest Bed Bug Killer, Liquid Spray with Odorless and Non-Staining Extended Residual Kill Formula (Gallon)
- Kills Resistant Bed Bugs & Their Eggs - Kills even the toughest "pyrethroid resistant" bed bugs and eggs that have built up a resistance to traditional pesticides
- Kills Quickly - Knocks down bed bugs fast when sprayed directly
- Long Residual - Continues to kill bed bugs for up to 16 weeks after initial application
- Odorless Formula - Odorless and non-staining formula will not cause damage to fabrics when used according to label directions
$59.99
SALE
−$13.04
MGK Crossfire® Bed Bug Concentrate | Kills Pyrethroid-Resistant Bed Bug Strains | 13 oz | Non-Staining
- PATENTED FORMULA: CrossFire bed bug spray kills pyrethroid-resistant bed bug strains at all life stages, including eggs. With its two active ingredients and a synergist, get effective bed bug control.
- QUICK KNOCKDOWN AND KILL: Begins working within minutes of exposure. This professional product is backed by multiple active ingredients.
- NON-STAINING: For indoor use in residential, institutional and commercial facilities, this bed bugs killer treatment is approved for direct application onto mattresses.
- EASY TO MIX AND USE: One 13-ounce bottle of bed bug concentrate makes one gallon of finished product.
- A LEGACY YOU CAN TRUST: Driven by expertise and industry commitment, MGK has been developing pest control products based primarily on botanical and innovative technologies since 1902.
$36.96
SALE
−$5.00
Eco Defense Bed Bug Killer - Bed Bug Spray & Dust Mite Spray - Natural Treatment - 16 oz
- KILLS ON CONTACT - Natural ingredients eliminate bed bugs on contact in all stages of life, Eggs, Nymphs, and Adults.
- NON STAINING - Won't stain your bedding like some products on the market. Apply directly to sheets, mattress and cover to kill bed bugs on site.
- SLEEP SECURE - Made of natural as well as plant-based ingredients. No worries of fumes or dangerous pesticides and chemicals coming in contact with you and your family
- FASTEST TREATMENT - Eco Defense Bed Bug Killer Spray works extremely fast and is easy to use. Many customers have found it easier to use and more effective than other Bed Bug products including, Bed Bug Powders, Bed Bug Traps, and Bed Bug Foggers. Rest assured, Eco Defense is your #1 solution.
$19.95
All Natural Bed Bug Spray - Non-Toxic Bed Bug Killer - 2 Bottle Value Bed Bug Spray Travel Size - Fast-Acting Bed Bug Killer | Kills Fleas and Mites
- Fast-acting bed bug elimination: Our Natural Bed Bug Spray 2-Pack delivers swift and effective treatment against bed bugs, eliminating both adult bugs and their eggs to halt infestations in their tracks.
- Convenient travel size: Each 3 oz bottle is perfectly sized for travel, ensuring you can effectively combat bed bugs wherever you go, whether it's a hotel room, vacation rental, or friend's house.
- Versatile formula: In addition to targeting bed bugs, our spray also tackles other pests like fleas and dust mites, providing comprehensive protection for your bedding and surrounding areas.
- Trusted bed bug treatment: Harnessing the power of natural ingredients, our bed bug spray offers a safe and eco-friendly solution for getting rid of bed bugs permanently, without the need for harsh chemicals or pesticides.
- Compatible with other treatments: Whether used alone or in conjunction with products like Crossfire bed bug concentrate or Cimexa bed bug killer, our spray enhances the effectiveness of your bed bug treatment regimen, ensuring thorough eradication of these pesky pests.
$9.99
SALE
−$4.30
Ecologic Bed Bug Killer, Kills Bed Bugs & Bed Bug Eggs, Use on Mattresses, Bed Frames, Suitcases and More, Aerosol Spray, 14 fl Ounce
- KILLS BED BUGS BY CONTACT: Aerosol spray kills bed bugs by contact, including pyrethroid-resistant bed bug and bed bug eggs.
- TREAT CRACKS AND CREVICES: Apply as a spot treatment to cracks and crevices around baseboards, floorboards, bedboards, carpet edges, walls and more.
- TREAT MATTRESSES: Use on mattresses, box springs, bed frames and luggage as listed.
- ACTIVE INGREDIENTS: Formulated with lemongrass oil and cornmint oil.
- SAFE AROUND KIDS AND PETS: When used and stored as directed.
$9.99
Last update on 2025-05-03 / Affiliate links / Images from Amazon Product Advertising API