Medicine for cramps can provide significant relief for those experiencing discomfort due to muscle spasms or menstrual pain. In 2025, various over-the-counter and prescription options are available, including nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, acetaminophen, and muscle relaxants. Additionally, natural remedies such as magnesium supplements and herbal teas have gained popularity for their effectiveness. It's essential to consult with a healthcare professional to determine the best course of action tailored to individual needs.
Midol Complete Menstrual Pain Relief Caplets, 40 Count - Provides Cramp, Headache, and Bloating Relief
- 1 box of 40 count Midol Complete Menstrual Pain Relief Caplets with Acetaminophen, Caffeine and Pyrilamine Maleate for Menstrual Symptom Relief
- Contains acetaminophen for effective period pain relief while also providing backache, muscle ache and headache relief
- Includes caffeine and pyrilamine maleate to relieve fatigue, bloating and water weight gain
- Available in easy to take caplet form for effective period pain and PMS relief you can take with you everywhere you go
- Take 2 caplets with water and repeat every six hours as needed, but don't take more than 6 caplets a day
$8.57
Pamprin Multi-Symptom Formula, with Acetaminophen, Menstrual Period Symptoms Relief including Cramps, Pain, Bloating, and Irritability 40 Caplets
- MULTI SYMPTOM PAIN RELIEF: These caplets provide aspirin & caffeine free relief for common menstrual symptoms like cramps, headaches, backaches, irritability & bloating. Prevents water weight gain.
- FOR CRAMPS, ACHES & BLOATING: These caplets feature 3 active ingredients to alleviate multiple symptoms of PMS & menstrual pain, including cramps, headache, back ache, irritability & bloating.
- TRIPLE COVERAGE: With an antihistamine to relieve irritability, a diuretic to fight bloating & water weight gain, & a pain reliever for cramps & aches, Pamprin Multi-Symptom offers complete coverage.
- MAXIMUM STRENGTH: The maximum strength caffeine-free formula of Pamprin Multi Symptom provides optimal relief for teen girls, adult women and anyone experiencing the discomfort and pain of Premenstrual Syndrome.
- PAMPRIN GOES BEYOND PAIN RELIEF: Unlike ordinary pain relievers, Pamprin was made specifically for periods & formulated to go beyond pain relief to relieve all symptoms associated with your period.
$8.89
SALE
−$1.00
Hyland's Leg Cramp Tablets, Natural Relief of Calf, Leg and Foot Cramp, Quick Dissolving Tablets, 100 Count
- PAIN RELIEF OF LEG CRAMPS: Natural relief of stiffness, pains in limbs, joints and legs, and cramps in calves, feet and legs
- EASY TO TAKE: Quick-dissolving tablets that melt in your mouth instantly to relieve symptoms of pain and cramps in legs and calves, pain in limbs and joints, cramps in feet.
- 100 TABLETS - UP TO 50 DOSES of Hyland's Leg Cramps quick-dissolving tablets.
- NATURAL MEDICINE: Naturally relieves the symptoms of stiffness, pains in limbs, joints, legs and cramps in calves, feet and legs; Hyland's is committed to providing natural solutions for families at every stage of life
- SAFE AND GENTLE: Hyland's formulas are made with natural active ingredients and have no known drug interactions.
$12.99
Pamprin Maximum Strength Max Pain and Energy Formula, Menstrual Period Symptoms Relief for Cramps, Bloating and Fatigue, 24 Caplets
- MAXIMUM STRENGTH MENSTRUAL PAIN RELIEF: With pain relieving aspirin and acetaminophen, Pamprin Max Pain + Energy is formulated to provide complete relief of menstrual cramps, headaches, backaches, and fatigue
- SAY GOODBYE TO BLOATING WATER WEIGHT GAIN: Pamprin Max Pain + Energy includes caffeine, which acts as a diuretic to relieve bloating and water weight gain many women experience as a result of period symptoms
- TWO PAIN RELIEVERS FOR COMPLETE RELIEF: With both aspirin and acetaminophen for pain relief, caffeine for water weight gain, fatigue, and bloating. Pamprin Max Pain + Energy offers complete coverage for PMS symptoms
- FOR TEENS AND ADULTS: Pamprin is recommended for use by adults and children aged 12 and older, meaning teens can take Pamprin for relief of premenstrual cramps and other period symptoms too
- PAMPRIN HAS MAXIMUM PAIN RELIEF: Pamprin Max Pain + Energy was made specifically for your most painful days & formulated to relieve period symptoms for maximum strength results
$5.73
Theraworx Relief for Muscle Cramps Foam Fast-Acting Muscle Spasm, Leg Soreness with Magnesium Sulfate - 7.1 oz - 1 Count
- Helps relieve muscle cramps and spasms
- Helps relieve post-cramp soreness
- Fast-acting and absorbs quickly
- No-mess, no strong odor
$18.96
Theraworx Relief for Muscle Cramps Roll-On Fast-Acting Muscle Spasm, Leg Soreness with Magnesium Sulfate - 2.5 oz - 1 Count
- Helps relieve muscle cramps, spasms, & post-cramp soreness
- Easy no-touch application
- Fast-acting and absorbs quickly
- No-mess, no strong odor
- Made with natural ingredients, safe to use daily
$11.87
Hyland's, Leg Cramps, 100 Tablets (2 Pack)
- RELIEF OF LEG CRAMPS: Natural relief of stiffness in limbs, joints and legs, and cramps in calves, feet and legs
- EASY TO TAKE: Quick-dissolving tablets that melt in your mouth instantly to relieve symptoms of cramps in legs and calves, limbs and joints, cramps in feet.
- 200 TABLETS - UP TO 100 DOSES of Hyland's Leg Cramps quick -dissolving tablets.
- NATURAL MEDICINE: Naturally relieves the symptoms of stiffness in limbs, joints, legs and cramps in calves, feet and legs; Hyland's is committed to providing natural solutions for families at every stage of life
- SAFE AND GENTLE: Hyland's formulas are made with natural active ingredients and have no known drug interactions. Expiration dates are clearly written on package and bottle. Amazon and Hyland's will not ship expired product.
$24.24
Boiron Cyclease Cramps Tablets for Relief from Menstrual Cramps, Aches, Pain, and Discomfort - 60 Count
- Boiron
- This medicine is aspirin- ibuprofen- and caffeine-free. Recommended for women ages 12 and up
- 60 Tablet Cyclease Cramp temporarily relieves minor aches and pains associated with menstrual cramps.
$9.29
SALE
−$1.40
Boiron Arnicare Leg Cramps for Day and Night Relief from Cramping and Stiffness in Feet or Calves - 33 Tablets
- ARNICA FOR PAIN: This homeopathic medicine helps temporarily relieve muscle pain & stiffness due to minor injuries, overexertion & falls. Also great for pain, swelling, & discoloration from bruises.
- RELIEVE CRAMPS: Arnica Leg Cramps chewable tablets are easy to take & help temporarily relieve day & night cramps & spasms in calves, legs, thighs, & arms, & cramps from muscular overexertion.
- PLANT-BASED ACTIVE INGREDIENT: The Arnica montana plant is a natural pain reliever. This popular homeopathic medicine temporarily relieves muscle pain & stiffness without unwanted drowsiness.
- HOMEOPATHIC MEDICINE uses highly diluted biological, botanical, or mineral substances to relieve symptoms. Our tablets, pellets, & topical treatments work with your body without the risk of contraindications, or known drug interactions.
- THE BOIRON PROMISE: We believe there’s more than one way to feel better. Since 1932, we have been committed to providing quality medicines. As a world leader in homeopathy, our passion is your health. Our promise is your satisfaction.
$10.59
Midol Complete Caffeine Free Caplets 24ct: Midol Complete Caffeine Free Menstrual Pain Relief Caplets with Acetaminophen, Provides Headache Relief and Period Cramps Relief, 24 Count
- MIDOL COMPLETE CAFFEINE FREE, Menstrual pain relief caplets with acetaminophen
- MENSTRUAL PAIN RELIEF: Provides backache pain relief, headache relief and period cramps relief for up to six hours
- MULTI-SYMPTOM PERIOD RELIEF: Contains pamabrom to combat bloating and acetaminophen to relieve cramps
- CAFFEINE FREE: New Midol Complete Caffeine Free also contains 500mg acetaminophen
- CONVENIENT FORM: Available in portable and easy to take caplet form
$6.37
Last update on 2025-05-03 / Affiliate links / Images from Amazon Product Advertising API