OTC acid reflux medicine offers effective relief for those suffering from heartburn and gastroesophageal reflux disease (GERD). In 2025, a variety of over-the-counter options are available, including antacids, H2 blockers, and proton pump inhibitors, each designed to neutralize stomach acid or reduce its production. Popular choices include famotidine, omeprazole, and ranitidine, which provide varying degrees of relief and duration of action. When selecting the right medication, it's essential to consider individual symptoms and consult with a healthcare professional if necessary.
SALE
−$1.26
Amazon Basic Care Maximum Strength Famotidine Tablets 20 mg, Acid Reducer Pills for Heartburn Relief, 200 Count (Packaging may vary)
- ACTIVE INGREDIENT: This product contains 20 mg of famotidine, an acid reducer for heartburn relief, which compares to the active ingredient in Maximum Strength Pepcid AC.
- RELIEVES HEARTBURN: Amazon Basic Care Maximum Strength Famotidine Tablets 20 mg help to relieve heartburn due to acid indigestion and sour stomach. PREVENTS
- HEARTBURN: Taken 10 to 60 minutes ahead of time, Amazon Basic Care Famotidine Tablets 20 mg prevents heartburn due to acid indigestion brought on by eating and drinking certain foods and beverages. JUST
- ONE TABLET prevents and relieves heartburn due to acid indigestion brought on by eating and drinking certain foods and beverages. This heartburn medicine lasts up to 12 hours. Use for adults & children 12 years and over. This product is gluten free.
- HEARTBURN MEDICINE: The active ingredient in Amazon Basic Care Famotidine Tablets 20 mg is an H2-blocker, which works as an acid reducer to help relieve heartburn. Lasts up to 12 hours. Use for adults and children 12 years and over.
$10.91
SALE
−$4.96
Amazon Basic Care Omeprazole Delayed Release Tablets 20 mg, Treats Frequent Heartburn, Acid Reducer, Heartburn Medicine, 42 Count (Pack of 1) (Packaging may vary)
- ACTIVE INGREDIENT: The active ingredient in these delayed release tablets is omeprazole 20 mg, which works as an acid reducer to treat frequent heartburn. Compare to Prilosec OTC
- TREATS FREQUENT HEARTBURN: Amazon Basic Care Omeprazole Delayed Release Tablets 20 mg treat frequent heartburn that occurs 2 or more times a week
- ACID REDUCER: Amazon Basic Care Omeprazole Delayed Release Tablets 20 mg is a Proton Pump Inhibitor (PPI) that deactivates pumps in the stomach lining to inhibit acid production at the source.
- 14-DAY COURSE OF HEARTBURN TREATMENT: Taken once every 24 hours for 14 days, Amazon Basic Care Omeprazole Delayed Release Tablets 20 mg is not intended for immediate relief of heartburn and may take 1 to 4 days for full effect.
- HEARTBURN TIPS: Do not eat late at night or just before bedtime. Certain foods or drinks are more likely to cause heartburn, such as rich, spicy, fatty and fried foods, chocolate, caffeine, alcohol and even some fruits and vegetables.
$10.84
HealthCareAisle Omeprazole 20 mg, 42 Delayed-Release Capsules - Acid Reducer, Treats Frequent Heartburn, 42 Count (Pack of 1)
- EFFECTIVE HEARTBURN RELIEF: Omeprazole acid reducer capsule that treats frequent heartburn occurring 2 or more days a week.
- 14-DAY ACID REFLUX MEDICINE:Take one Omeprazole capsule daily for heartburn relief up to 24 hours. May take 1-4 days for full effect. See package label for warnings and other important information.
- COMPARABLE TO THE NATIONAL BRAND: Has the same active ingredient as Prilosec OTC*
- STOP HEARTBURN AT THE SOURCE: Our Omeprazole 20mg capsules inbibit the proton pumps in the stomach from producing excess acid, acting as an acid reducer.
- Directions: use as directed for 14 days; do not take for more than 14 days or more often than every 4 months unless directed by your healthcare provider
$11.21
Glenmark Maximum Strength Famotidine Tablets, 20 mg, Acid Reducer for Heartburn Relief, 200 Count
- ACTIVE INGREDIENT: This item’s formula includes 20 mg of Famotidine, which is an acid reducer for heartburn relief.
- EFFECTIVE: Acid Reducers like Famotidine Tablets, 20 mg can prevent and relieve heartburn due to sour stomach and acid indigestion. Only one tablet relieves and prevents heartburn due to acid indigestion.
- WHAT IS HEARTBURN? Heartburn occurs when stomach contents flow back up into the esophagus—the muscular tube that carries food and liquids from the mouth to the stomach. A heartburn medicine like Famotidine Tablets,20 mg helps provide heartburn relief.
- MANAGING HEARTBURN: Tips for managing heartburn include: Do not lie flat or bend over after eating, Do not wear tight-fitting clothing around the stomach, Do not eat before bedtime, Raise the head of your bed, Avoid heartburn-causing foods such as rich, spicy, fatty or fried foods, chocolate, caffeine, alcohol, and certain fruits and vegetables Eat slowly and avoid big meals If overweight, lose weight Quit smoking
- TYPES OF HEARTBURN MEDICINE: This product is an H2 blocker and it works to reduce acid in an attempt to relieve mild heartburn or indigestion. Lasts 12 hours.
$8.99
SALE
−$3.22
Amazon Basic Care Esomeprazole Magnesium Delayed Release Capsules, 20 mg, Acid Reducer, Heartburn Medicine, 42 Count
- EFFECTIVE: Active ingredient in Amazon Basic Care Esomeprazole Magnesium Delayed Release Capsules, esomeprazole, 20 mg, acid reducer; compare to the active ingredient in Nexium 24 HR
- ACID REDUCER: Inhibits acid production at the source; enjoy foods and beverages that could cause frequent heartburn
- PROVEN HEARTBURN TREATMENT: Clinically proven to treat frequent heartburn that occurs 2 or more days a week
- HEARTBURN TREATMENT: Take once every 24 hours for 14 days; this heartburn medicine may take 1 to 4 days for full effect
- GLUTEN FREE: Amazon Basic Care Esomeprazole Magnesium Delayed Release Capsules, 20 mg; gluten free
$12.50
Amazon Basic Care Esomeprazole Magnesium Delayed-Release Mini Capsules, 20 mg, Acid Reducer, 24 Hour Heartburn Medicine, 42 Count
- ACTIVE INGREDIENT, each mini capsule is esomeprazole 20 mg, acid reducer; each delayed-release mini capsule corresponds to 22 mg esomeprazole magnesium dihydrate; compare to the active ingredient in Nexium 24 HR Clear Minis
- ACID REDUCER: Esomeprazole magnesium deactivates acid-producing pumps in the stomach lining; inhibits acid production at the source; may take 1 to 4 days for full effect, not intended for immediate relief
- PROVEN HEARTBURN TREATMENT: Clinically proven to treat frequent heartburn that occurs 2 or more days a week; one dose per day; 14-day course of treatment.
- 24 HOUR MINI CAPSULES: Mini capsules, smaller size than regular sized Amazon Basic Care Esomeprazole Magnesium Delayed-Release Capsules, 20 mg, Acid Reducer
- AMAZON BASIC CARE ESOMEPRAZOLE MAGNESIUM DELAYED-RELEASE MINI CAPSULES 20 mg: Treats frequent heartburn in adults age 18 years of age and older; gluten free
$16.55
TUMS Chewy Bites Antacid Tablets for Chewable Heartburn Relief and Acid Indigestion Relief, Assorted Berries - 60 Count
- Comes in a container
- Reduces stomach acid
- Take two or three
- Instantly neutralizes acid
- Take on the go
$9.98
Last update on 2025-05-02 / Affiliate links / Images from Amazon Product Advertising API