Best flea treatments for cats in 2025 offer a range of effective solutions to keep your feline friend free from pesky parasites. From topical treatments to oral medications, these products are designed to eliminate fleas quickly and prevent future infestations. Leading brands have developed innovative formulas that are safe for cats while providing long-lasting protection. Whether you prefer a natural approach or a vet-recommended option, there’s a product on the market to suit your needs. Ensure your cat's comfort and health by choosing one of the top-rated flea treatments available this year.
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FRONTLINE Plus Flea and Tick Treatment for Cats Over 1.5 lbs. 3 Treatments
- FRONTLINE Plus for Cats provides waterproof, fast-acting, long-lasting flea and tick protection that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease
- Break the flea life cycle with FRONTLINE Plus for Cats, specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea & tick control
- Trusted by pet owners for over 20 years, FRONTLINE Plus for Cats can be used on kittens as young as eight weeks old, weighing 1.5 pounds or more; One monthly dose provides protection from fleas & ticks for a full 30 days
- Even indoor dogs need flea and tick control because you or other pets in the household may bring fleas into the home; These fleas can lead to a flea infestation
- FRONTLINE Plus also comes in a formula designed for dogs and puppies, 8 weeks and older, weighing 5 lbs and over, providing the same reliable flea & tick protection
$39.97
Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 6-Month Supply
- Advantage II Large Cat is a leading brand in cat flea treatment and prevention for large cats over 9 lbs., at least 8 weeks of age
- Vet-recommended, easy-to-apply monthly topical treatment – no hard-to-swallow pills, no prescription needed
- Delivers total flea protection – kills adult fleas, flea larvae and flea eggs through contact
- Same-day effectiveness – kills fleas within 12 hours of application and keeps working for 30 days
- Fragrance-free formula, waterproof after 24 hours of application
$68.98
FRONTLINE® Gold for Cats Flea & Tick Treatment (Cats over 1.5 lbs.) 3 Doses
- From the #1 Name in Flea and Tick Protection* *Data on file at Boehringer Ingelheim.
- Easy to use flea and tick protection
- Kills adult fleas, flea larvae, flea eggs and ticks
- Waterproof formula
- Keeps protecting through day 30
$62.99
Amazon Basics Flea and Tick Topical Treatment for Cats (over 1.5 lbs), 6 Count (Previously Solimo)
- Same product, new look―This product is identical in manufacturing and formulation as the Solimo brand
- One 6 dose pack of Amazon Basics Flea & Tick Treatment for Cats (over 1.5 lbs)
- Amazon Basics Flea & Tick starts eliminating fleas and ticks within 24 hours of treatment
- Active ingredients (list ingredients) prevent flea infestations by killing flea eggs, flea larvae, mosquitos, biting flies and chewing lice
- One application provides up to 30 days of protection
$24.29
PetArmor Plus Flea and Tick Prevention for Cats, Cat Flea and Tick Treatment, 6 Dose, Waterproof Topical, Fast Acting, Cats Over 1.5 lbs
- EFFECTIVE, WATERPROOF FLEA TREATMENT FOR CATS: PetArmor Plus is a waterproof, flea & tick topical prevention for cats that kills fleas, flea eggs, flea larvae, ticks, and chewing lice for up to 30 days after application.
- TRUSTED, VET QUALITY FORMULA: Containing fipronil and (S)-methoprene, the same active ingredients as FRONTLINE Plus for Cats. PetArmor Plus for Cats has a powerful formula that starts to kill fleas within 24 hours.
- BREAK THE FLEA CYCLE: Unlike other flea and tick treatments that may temporarily suppress flea activity, PETARMOR Plus Cat Flea Treatment works by effectively breaking the flea life cycle. Kill flea eggs and larvae to prevent re-infestation.
- FLEA AND TICK PROTECTION: PetArmor Plus for Cats flea drops protects your furry family members from brown dog ticks, American dog ticks, Lone Star ticks, and deer ticks (which may transmit Lyme disease).
- EASY-TO-USE, LONG-LASTING: PetArmor Plus flea and tick treatment comes with six (6) waterproof topical applications that provide your pet flea protection and control for (6) months
$39.93
TevraPet FirstAct Plus Flea and Tick Prevention for Cats Over 1.5lbs, 6 Monthly Doses, Topical Drops
- COMPARE TO FRONTLINE PLUS FOR CATS - Contains fipronil and (S)-Methoprene, the same fast acting, vet quality active ingredients as the leading brand
- Breaks flea life cycle - FirstAct Plus topical stops infestations and prevents new ones. Repels and kills fleas and ticks on contact, and kills flea eggs and larvae, chewing lice, and all stages of ticks including those that may transmit Lyme disease
- Powerful and affordable flea protection - your cat is protected Tip to Tail for 30 days with each easy to apply application
- 6 month supply - includes 6 topical doses of flea and tick prevention; apply these flea drops to the base of your cat's neck once every 30 days
- RESULTS GUARANTEED: Made in Germany in a certified eu-gmp facility, tested to meet rigorous standards of quality and consistency
$34.97
Advantage II Small Cat Vet-Recommended Flea Treatment & Prevention | Cats 5-9 lbs. | 6-Month Supply
- Advantage II Small Cat is a leading brand in cat flea treatment and prevention for small cats 5-9 lbs., at least 8 weeks of age
- Vet-recommended, easy-to-apply monthly topical treatment – no hard-to-swallow pills, no prescription needed
- Delivers total flea protection – kills adult fleas, flea larvae and flea eggs through contact
- Same-day effectiveness – kills fleas within 12 hours of application and keeps working for 30 days
- Fragrance-free formula, waterproof after 24 hours of application
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TevraPet Actispot II Flea Treatment for Large Cats 9+ lbs | 6 Doses | Powerful Prevention and Control
- POWERFUL FLEA KILLING TREATMENT FOR LARGE CATS: TevraPet Actispot II is a waterproof topical for cats that kills fleas, flea eggs, and flea larvae for up to 30 days after each application
- VET APPROVED FORMULA: TevraPet Actispot II uses Imidacloprid and Pyriproxyfen - the same safe and effective active ingredients found in Advantage II - but costs far less. Every cat deserves veterinarian quality treatment, Actispot II helps you provide the same level of care without breaking the bank
- FAST ACTING AND LONG-LASTING WITH NO BITING REQUIRED: TevraPet Actispot II REPELS and KILLS fleas on contact, without your cat being exposed to bites. Begins killing within 24 hours of application, and starts repelling immediately. Other oral flea tablets, pills, and chews require that your pet is bitten by a pest before the meds can start working, potentially exposing your kitty to flea borne diseases
- BREAK THE CYCLE, PREVENT REINFESTATION: Unlike other flea medications that only temporarily control fleas, Actispot II flea treatment stops infestations dead in their tracks by effectively breaking the flea life cycle. Actispot II safely kills flea eggs and larvae to prevent re-infestation so your cat can get on with napping in the sun and strolling (or stalking!) through the garden
- EASY-TO-USE, MADE IN AMERICA: We proudly make every dose of Actispot II here in the USA and rigorously test for quality and potency. Each package comes with six (6) easy to apply, fully waterproof topical applications that ensure your friend has safe and reliable flea protection and control for up to six (6) months
$29.97
Frontline Gold for Cats (6 Month)
- New easy to use applicator
- Frontline gold has a new and improved triple action formula
- Each dose lasts a full month
- Kills fleas, ticks and chewing lice
- Starts killing fleas in just 30 minutes
$104.50
PetArmor Plus Flea and Tick Prevention for Cats, Cat Flea and Tick Treatment, 1 Dose, Waterproof Topical, Fast Acting, Cats Over 1.5 lbs
- Effective, Waterproof Flea Treatment for Cats: PetArmor plus topical flea and tick Prevention for cats kills fleas, flea eggs, flea larvae, ticks, and chewing lice for up to 30 days after application
- Trusted, Vet Quality* Formula: this vet-quality formula flea treatment contains fipronil and begins killing fleas & ticks within 24 hours
- Break the Flea Cycle: Unlike other flea and tick treatments that may temporarily suppress flea activity, PETARMOR Plus Cat Flea Treatment works by effectively breaking the flea life cycle! Kill flea eggs and larvae to prevent re-infestation
- Fast-Acting Long-Lasting Flea and tick Protection: PetArmor plus for cats helps you protect your furry family member from the diseases fleas and ticks carry, including deer ticks that may transmit Lyme disease
- Easy-to-Use, Long-Lasting: PetArmor Plus flea and tick treatment comes with one (1) waterproof topical application that provide your pet flea protection and control for one (1) months
$12.98
Last update on 2025-05-02 / Affiliate links / Images from Amazon Product Advertising API