Zit cream is an essential product for anyone struggling with acne and blemishes, and the market is filled with options that promise quick results. In 2025, the best zit creams combine powerful ingredients like salicylic acid, benzoyl peroxide, and natural extracts to effectively target breakouts while minimizing irritation. These top-rated formulations not only help clear existing pimples but also prevent future outbreaks, making them a must-have in your skincare routine. Whether you prefer spot treatments or all-over solutions, there's a zit cream out there to suit your needs.
SALE
−$4.00
Neutrogena On-The-Spot Acne Treatment Gel with Benzoyl Peroxide - Gentle Face Acne Medicine for Acne Prone Skin, 0.75 oz
- .75-ounce tube of Neutrogena On-The-Spot Acne Spot Treatment cream with benzoyl peroxide to fight acne while gentle on skin
- Vanishing cream formula of this acne spot treatment is lightweight, absorbs quickly and works invisibly hour after hour to give long-lasting acne treatment
- On-The-Spot treatment is clinically proven to be so effective that skin starts getting clearer on day 1 to without over-drying, stinging or burning skin
- This gentle daily acne blemish treatment can be used up to three times a day. It's formulated with 2.5% benzoyl peroxide acne medicine, to help treat and prevent acne
- The acne-fighting formula goes deep down into pores to kill acne bacteria that causes pimples and helps stop new ones from forming
$7.99
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−$3.32
AcneFree Terminator 10 Acne Spot Treatment with Benzoyl Peroxide 10% Maximum Strength Acne Cream Treatment, 1 Ounce - Pack Of 1
- Severe Acne Spot Treatment: Maximum strength, 10% Benzoyl Peroxide fights severe acne and prevents new acne from forming. Dermatologist developed and tested; Oil free and fragrance free
- Reduces Redness and Soothes: Ginger is an effective treatment for acne, fighting active blemishes and treating skin until cleansing while Chamomile soothes
- Healthy Skin Solutions: We carry a full line of treatment kits, cleansers, moisturizers, detox masks, scrubs, creams, toners and other targeted solutions for sensitive, oily and acne prone skin
- Dermatology Inspired Care: Our products offer hydration, soothing, detoxifying and mattifying benefits to help ensure your skin looks and feels healthy and help maintain your skin’s balance with consistent use
- Dermatologist Recommended: Built on a foundation of dermatological science and research, doctors consistently recommend our products to men, women, teens and adults in need of gentle yet effective acne treatment
$4.67
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−$3.71
Neutrogena Rapid Clear Stubborn Acne Spot Treatment Gel with Maximum Strength 10% Benzoyl Peroxide Acne Treatment Medication, Pimple Cream for Acne Prone Skin Care, 1 oz
- 1-ounce tube of Neutrogena Rapid Clear Stubborn Acne Spot Treatment Gel with maximum-strength 10% benzoyl peroxide acne medication to help fight acne and prevent future breakouts for clearer looking skin
- This effective acne-fighting spot gel is clinically proven to rapidly reduce the size and redness of stubborn acne in just 2 hours and actively fights breakouts, for continuous improvement in skin's appearance throughout the day
- Its maximum strength formula contains 10% benzoyl peroxide, the acne medication dermatologists recommend most for clearer skin without a prescription
- From a dermatologist recommended brand, this maximum-strength daily stubborn acne treatment is specially formulated for acne-prone skin to help manage acne and clear breakouts
- Cleanse skin thoroughly before applying acne pimple spot treatment gel then proceed to cover affected area with a thin layer of acne gel 1 to 3 times daily
$9.68
Differin Acne Treatment Gel, 30 Day Supply, Retinoid Treatment for Face with 0.1% Adapalene, Gentle Skin Care for Acne Prone Sensitive Skin, 15g Tube (Packaging May Vary)
- TARGETS ACNE: Clears breakouts where they start (Deep in pores) and prevents new acne from forming, which ultimately restores skin's texture and tone
- CLEARS, TREATS & PREVENTS: Differin works differently than other Acne treatments by normalizing skin cell turnover and effectively targets two primary causes of Acne, clogged pores and inflammation
- RX STRENGTH ACNE RETINOID: Adapalene was created for superior tolerability compared to other prescription retinoid products not containing Adapalene; It is suitable for use as part of your morning or evening regimen
- DERMATOLOGIST RECOMMENDED: Water based formula, oil free, alcohol free, fragrance free, non comedogenic; Helps reduce the risk of scarring and Hyperpigmentation by treating Acne
- REAL RESULTS: In a clinical study, Differin gel provided up to 87 percent reduction in acne breakouts after 12 weeks, which will continue to improve with further use
$14.97
Amazon Basics 10% Benzoyl Peroxide Acne Medication, Maximum Strength, 1 Fluid Ounce Face Gel
- One 1-fluid ounce tube of benzoyl peroxide acne medication for the treatment of acne
- Dermatologist tested for Treatment of Acne
- Compare to Clean and Clear Persa-Gel 10 maximum strength
- Active ingredient: 10% Benzoyl Peroxide acne medication
- An Amazon Brand
$5.24
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−$2.02
Clean & Clear, Persa-Gel 10 Acne Spot Treatment, Maximum Strength, 1 Oz
- 1-ounce tube of Clean & Clear Persa-Gel 10 Oil-Free Acne Spot Treatment with Maximum Strength 10% Benzoyl Peroxide acne medication to help effectively treat pimples and reduce acne in just one day
- Fragrance free acne spot treatment is ideal for inflamed acne bumps. The face gel contains micronized benzoyl peroxide acne medication that goes to work immediately to help fight pimples and blemishes
- The benzoyl peroxide spot treatment for acne penetrates deep down into pores where acne begins. The acne treatment visibly reduces blemish size and acne redness in just one day
- This maximum strength acne treatment is formulated free of parabens, phthalates, fragrance, oil and dyes. It features a vegan formula that is not tested on animals and is packaged in a recyclable carton
- Suitable for acne-prone or oily skin, fragrance free Persa-Gel 10 reduces acne in just one day. To use, clean the skin and apply a thin layer of spot treatment to affected areas one to three times a day as a part of your daily acne skincare routine
$5.97
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−$1.47
Clearasil Stubborn Acne Control 5in1 Spot Treatment Cream, Maximum Strenght with 10% Benzoyl Peroxide, Acne Medication, 1 oz
- Clears existing pimples and helps prevent new ones from forming
- Vanishing acne cream formula penetrates pores to treat pimples
- 24 hour control works with your skin long after application
- With this acne cream you get visibly clearer skin every day.
- Dermatologist tested
$5.27
Mighty Patch™ Original patch from Hero Cosmetics - Hydrocolloid Acne Pimple Patch for Covering Zits and Blemishes in Face and Skin, Vegan-friendly and Not Tested on Animals (36 Count)
- The Original Award-Winning Acne Patch: Mighty Patch Original patch is a hydrocolloid sticker that improves the look of pimples overnight without the popping. Just stick it on, get some sleep, and wake up with clearer-looking skin.
- Results in 6-8 Hours: Absorbs pimple gunk thanks to our medical-grade hydrocolloid. Clinically tested, drug-free, and safe for all skin types.
- All-Night Adhesion: Strong enough to stay on through a whole night of tossing, turning, and pillow-squishing. Easy to remove in the AM without redness or irritation.
- Blends Seamlessly into Skin: The thin sticker with a translucent matte finish keeps your pimple under wraps day or night. You might just forget you’re even wearing it.
- Peace-Of-Mind Design: Our hydrocolloid patches are UV sterilized, and allergy tested. Each box comes with 36 medium dots (12 millimeters) on easy-peel perforated sheets.
$12.99
SALE
−$8.71
Proactiv Emergency Blemish Relief Benzoyl Peroxide Gel Acne Spot Treatment for Face and Body, white, 0.33 Oz
- EMERGENCY RELIEF: This invisible benzoyl peroxide spot treatment contains a powerful dose of microcrystal benzoyl peroxide to target acne-causing bacteria inside pores to clear up acne blemishes.
- YOU NEED MORE THAN A PIMPLE CREAM: Proactiv's benzoyl peroxide acne treatment is designed to unclog pores and is specially formulated to help absorb excess oil and clear emergency blemishes fast.
- PERFECT FOR ON THE GO: Unexpected blemishes can happen any time, so this pocket-sized spot treatment can go wherever you do.
- SAFE FOR ALL AGES: Proactiv's acne skin care treatment provides the same powerful skin care for teens and adults.
- MADE FOR YOUR SKIN: Proactiv Solution delivers benzoyl peroxide microcrystals deep into your pores to help stop acne-causing bacteria in its tracks and prevent new breakouts from forming.
$13.29
Last update on 2025-05-03 / Affiliate links / Images from Amazon Product Advertising API