Cold medicine is essential for alleviating the discomfort associated with colds, providing relief from symptoms such as congestion, cough, and sore throat. In 2025, the market offers a variety of effective options, each designed to target specific symptoms and improve overall comfort. From decongestants to antihistamines, the best cold medicines combine proven ingredients to help you recover faster and feel better. Whether you prefer liquid formulations or tablets, there’s a cold medicine that suits your needs.
SALE
−$2.52
Alka-Seltzer Plus Severe, Cold & Flu Medicine, Citrus Effervescent Tablets, Nasal & Sinus Congestion, Sneezing, Runny Nose, Cough, Sore Throat 24 Count, Packaging May Vary
- Our fantastic formula made even better: improved flavor, less sodium, & aspartame free
- Our severe Cold & Flu medicine formula provides unbeatably liquid fast relief of headache, sore throat, cough, nasal & sinus congestion, runny nose, sneezing, aches & pains and fever.
- Quickly dissolves in water and instantly ready to start working so you can get back to your busy life.
- Each box containing 10 Sachets each containing 1 individually wrapped dose (2 effervescent tablets), which makes it easy to take with you on the go
- Comes in Effervescent form, in a refreshing Citrus flavor. Use as directed.
$9.47
VICKS DayQuil & NyQuil High Blood Pressure Cold & Flu Relief Liquid Medicine Co-Pack, Powerful Multi-Symptom Daytime & Nighttime Relief for Cold, Cough, and Flu Symptoms, Sugar & Alcohol Free, 2x8oz
- SPECIALLY FORMULATED COLD & FLU RELIEF FOR PEOPLE WITH HIGH BLOOD PRESSURE. High blood pressure means some medicines are off limits. Not these! Specially formulated to be decongestant, sugar, and alcohol free.
- FAST, POWERFUL MULTI-SYMPTOM RELIEF. Use non-drowsy DayQuil for daytime relief and at night try NyQuil for fast relief so you can rest.
- EFFECTIVE COLD & FLU SYMPTOM RELIEF. DayQuil and NyQuil Cold & Flu medicine temporarily relieve common cold & flu symptoms. Just one dose starts working fast to provide effective cold & flu relief
- POWER THROUGH YOUR WORST COLD & FLU SYMPTOMS. Life doesn’t stop when you have a cold. DayQuil and NyQuil relieve bothersome symptoms, such as cough and fever, day or night.
- WORLD'S #1 SELLING OTC COUGH AND COLD BRAND. Vicks has been trusted for over 125 years to relieve your worst cold & flu symptoms.
$16.59
Amazon Basic Care Vapor Ice Day and Night Severe Cold and Flu Relief Caplets, Maximum Strength Medicine, Combo Pack, 48 Count
- ACTIVE INGREDIENTS: Amazon Basic Care Vapor Ice Daytime and Nighttime Severe Cold and Flu help to relieve common cold and flu symptoms, day and night; compare to the active ingredients in Vicks DayQuil and NyQuil Severe VapoCOOL
- EFFECTIVE: Daytime relieves minor aches and pains, fever, nasal congestion, sinus pressure, cough and chest congestion; Nighttime relieves minor aches and pains, fever, nasal congestion, sinus pressure, sneezing, runny nose and cough
- COMBINATION PACK: Amazon Basic Care Vapor Ice Daytime and Nighttime Severe Cold and Flu comes in a combination pack for around-the-clock maximum strength, multi-symptom relief for your worst cold and flu symptoms
- COATED CAPLETS: Contain pain reliever/fever reducer, cough suppressant, nasal decongestant, antihistamine, expectorant (antihistamine in nighttime only, expectorant in daytime only)
- MAXIMUM STRENGTH: Get day and night cold and flu relief with these max strength coated caplets. Relieve sore throat and other cold and flu symptoms with Amazon Basic Care Vapor Ice Daytime and Nighttime Severe Cold and Flu
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Amazon Basic Care Tussin Severe CF Max Syrup, Multi-Symptom Cough, Cold and Flu Liquid Medicine, Non-Drowsy, Relieves Cough, Sore Throat, Body Aches, Fever, Nasal and Chest Congestion, 8 fl oz
- ACTIVE INGREDIENTS: This cold medicine contains a pain reliever/fever reducer, cough suppressant, expectorant and nasal decongestant. Compare to the active ingredients in Robitussin Severe Multi-Symptom Cough Cold + Flu.
- MAXIMUM STRENGTH: This cold medicine provides maximum strength relief of multiple cold and flu symptoms such as cough, nasal congestion, sinus congestion and pressure, minor aches and pains, sore throat, headache and temporarily reduces fever.
- MUCUS RELIEF: Take this cold medicine to help loosen phlegm (mucus) and thin bronchial secretions to drain bronchial tubes and make coughs more productive.
- NON-DROWSY: This non-drowsy cold and flu medicine provides relief for adults and children age 12 years and over. Dosage cup included.
- GREAT TASTING COLD MEDICINE: Amazon Basic Care Tussin CF Max, Multiple Symptom Cough Cold & Flu is gluten free, sugar free and alcohol free. Maximum strength claim based on maximum levels of active ingredients per 4 hour dose.
$5.01
VICKS DayQuil & NyQuil SEVERE Honey Flavor Co-Pack, Cold & Flu Medicine, RelievesHeadache, Fever, Sore Throat, Minor Aches & Pains, Nasal Congestion, Sinus Pressure, Stuffy Nose, and Cough, 2x12oz
- GREAT-TASTING HONEY FLAVORED DAYQUIL AND NYQUIL: Get the same cold & flu relief you expect from DayQuil & NyQuil SEVERE in a great-tasting honey-licious flavor
- POWERFUL, MAXIMUM STRENGTH 9-SYMPTOM RELIEF DAY AND NIGHT: Use non-drowsy DayQuil SEVERE Honey for daytime and at night try NyQuil SEVERE Honey for fast relief so you can rest
- POWERFUL COLD & FLU RELIEF: DayQuil and NyQuil SEVERE Honey formulas are flavored with real honey & temporarily relieve common cold & flu symptoms
- PROVEN RELIEF FOR YOUR WORST COLD & FLU SYMPTOMS: Life doesn't stop when you have a cold; NyQuil and DayQuil SEVERE Honey tackle your most bothersome cold & flu symptoms
- WORLD'S TOP SELLING OTC COUGH AND COLD BRAND: Vicks has been trusted for over 125 years to relieve your worst cold & flu symptoms
$19.97
SALE
−$1.53
Mucinex DM 12Hr Maximum Strength Chest Congestion & Cough Medicine For Adults, Cold And Cough Medicine for Excess Mucus Relief, 1200 mg Guaifenesin & 60 mg Dextromethorphan HBr, 14 Bi-Layer Tablets
- MAXIMUM STRENGTH MUCINEX DM COUGH & CHEST CONGESTION MEDICINE: Clinically proven to last up to 12 hours to control cough and provide relief for your severe chest congestion
- POWERFUL SYMPTOM RELIEF: Maximum Strength Mucinex DM 12 hour controls cough, relieves chest congestion and thins & loosens mucus.
- BI-LAYER TABLET: A unique bi-layer tablet, one layer for immediate release and one layer for extended release so the medicine starts to release right away and last for up to 12 hours
- #1 TRUSTED COLD & COUGH BRAND: Mucinex is the #1 Cold and Cough brand doctors trust* and #1 Pharmacist Recommended Brand
- CONTINUOUS RELIEF: Maximum strength Mucinex DM lasts up to 12 hours so you can say goodbye to retaking medicine every 4 hours
$13.46
SALE
−$1.02
Alka-Seltzer Plus Power Max Cold and Flu Medicine, Day+Night, - Maximum Strength (Per 4 Hour Dose) Relief Cold and Flu Medicine for Adults and Children 12 Years and Older, 24 Count, Packaging May Vary
- Alka-Seltzer Plus Power Max Cold and Flu Medicine is designed for cold and flu symptoms and provides timely relief *Use as directed.
- One dose provides 4 hour day time or night time cold and flu relief of cough, nasal congestion, fever, sinus congestion, headache & body ache, sore throat, and sinus pressure
- Cold and flu medicine for adults and children 12 years and older that contains a pain reliever, fever reducer, cough suppressant, antihistamine (night time only), and nasal decongestant
- Temporarily relieves these symptoms due to cold and flu: Minor aches and pains, cough, headache, sore throat, nasal and sinus congestion, runny nose, & sneezing (runny nose & sneezing apply to night time dosage only).
- The medicine contains a powerful combination of active ingredients, including dextromethorphan, that helps relieve cough.
$9.47
Vicks DayQuil LiquiCaps, Cough, Cold & Flu Relief, Sore Throat, Fever, & Congestion Relief, Non- Drowsy, 24 LiquiCaps
- POWERFUL MULTI-SYMPTOM RELIEF for your headache, fever, sore throat, minor aches and pains, nasal congestion, sinus pressure, and cough
- NON-DROWSY, DAYTIME COLD & FLU RELIEF; DayQuil Cold & Flu Liquicaps temporarily relieve common cold & flu symptoms so you can get on with your day
- FEEL BETTER FAST; Just one dose of DayQuil starts working fast to provide effective cold & flu relief
- POWER THROUGH YOUR WORST COLD & FLU SYMPTOMS; Life doesn't stop when you have a cold; DayQuil relieves bothersome symptoms such as cough and fever so that you can power through your day
- WORLD'S #1 SELLING OTC COUGH AND COLD BRAND; Vicks has been trusted for over 125 years to relieve your worst cold & flu symptoms
$9.79
TUKOL Max Action Severe Congestion & Cough Medicine for Adults – Expectorant Cough Syrup, DM Cough Syrup, Dry Cough Cold and Sore Throat Medicine, Chest Decongestant,12+ Years, 6 Fl Oz
- [ MULTI-SYMPTOM RELIEF FOR SEVERE COLD AND COUGH ]: Tukol Max Action offers a powerful solution to relieve cough, nasal, and chest congestion, making it easier to breathe and alleviating discomfort so you can continue your day without interruptions
- [ POWERFUL EXPECTORANT AND COUGH SUPPRESSANT ]: Helps thin mucus and relieve chest congestion, making it easier to expel, while also calming persistent coughs for fast, effective relief
- [ NON-DROWSY FORMULA FOR DAYTIME RELIEF ]: Designed for daytime use, this non-drowsy cough syrup targets multiple cold symptoms like cough, nasal, and chest congestion, allowing you to stay productive while feeling better
- [ ACTIVE INGREDIENTS FOR MAXIMUM RELIEF ]: Contains Dextromethorphan HBr to suppress cough and Guaifenesin to loosen mucus, providing fast, targeted relief from cold and cough symptoms
- [ EASY DOSAGE FOR ADULTS ]: For adults and children 12 years and older, take 20 mL every 4 hours as needed. Do not exceed 6 doses in 24 hours. Use the provided measuring cup for accurate dosage and fast relief from cough and congestion
$8.12
Zicam Cold Remedy Zinc Lozenges, Elderberry Flavor, Homeopathic, Soothes Sore Throat and Coughs, Cold Shortening Medicine, Shortens Cold Duration, 25 Count
- MADE WITH ZINC: These cold remedy lozenges contain zinc, which helps shorten the length of colds when taken at the first sign.
- SHORTEN YOUR COLD: Our lozenges are different from most other cold medicine that just treats symptoms; They shorten colds when taken at the first sniffle, sneeze or cough.
- GREAT TASTING: Getting better tastes better with Zicam Cold Remedy. These delicious lozenges are individually wrapped which makes them convenient to take anywhere; They're also non-drowsy and non-habit forming.
- GET RID OF YOUR COLD FASTER: Zicam Cold Remedy products shorten colds when taken at the first sign, so you feel better faster; Zicam Cold Remedy products are available in a wide range of forms and flavors.
- OUR PRODUCTS: Our homeopathic Zicam Cold Remedy products are the #1 pharmacist recommended brand.* Zicam also offers a range of products for homeopathic allergy relief, nasal congestion, and sinus relief. *For zinc cold remedies, zinc lozenges, and homeopathic cold products
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Last update on 2025-05-03 / Affiliate links / Images from Amazon Product Advertising API