Cystic acne can be particularly stubborn and painful, making effective spot treatments essential for relief. The best spot treatment for cystic acne combines powerful ingredients like salicylic acid, benzoyl peroxide, and natural extracts to target inflammation and reduce breakouts. These treatments not only help to unclog pores but also soothe the skin, promoting faster healing. Whether you prefer gels, creams, or patches, finding the right product can make a significant difference in managing cystic acne.
SALE
−$2.80
AcneFree Terminator 10 Acne Spot Treatment with Benzoyl Peroxide 10% Maximum Strength Acne Cream Treatment, 1 Ounce - Pack Of 1
- Severe Acne Spot Treatment: Maximum strength, 10% Benzoyl Peroxide fights severe acne and prevents new acne from forming. Dermatologist developed and tested; Oil free and fragrance free
- Reduces Redness and Soothes: Ginger is an effective treatment for acne, fighting active blemishes and treating skin until cleansing while Chamomile soothes
- Healthy Skin Solutions: We carry a full line of treatment kits, cleansers, moisturizers, detox masks, scrubs, creams, toners and other targeted solutions for sensitive, oily and acne prone skin
- Dermatology Inspired Care: Our products offer hydration, soothing, detoxifying and mattifying benefits to help ensure your skin looks and feels healthy and help maintain your skin’s balance with consistent use
- Dermatologist Recommended: Built on a foundation of dermatological science and research, doctors consistently recommend our products to men, women, teens and adults in need of gentle yet effective acne treatment
$5.19
SALE
−$4.00
Neutrogena On-The-Spot Acne Treatment Gel with Benzoyl Peroxide - Gentle Face Acne Medicine for Acne Prone Skin, 0.75 oz
- .75-ounce tube of Neutrogena On-The-Spot Acne Spot Treatment cream with benzoyl peroxide to fight acne while gentle on skin
- Vanishing cream formula of this acne spot treatment is lightweight, absorbs quickly and works invisibly hour after hour to give long-lasting acne treatment
- On-The-Spot treatment is clinically proven to be so effective that skin starts getting clearer on day 1 to without over-drying, stinging or burning skin
- This gentle daily acne blemish treatment can be used up to three times a day. It's formulated with 2.5% benzoyl peroxide acne medicine, to help treat and prevent acne
- The acne-fighting formula goes deep down into pores to kill acne bacteria that causes pimples and helps stop new ones from forming
$7.99
SALE
−$3.71
Neutrogena Rapid Clear Stubborn Acne Spot Treatment Gel with Maximum Strength 10% Benzoyl Peroxide Acne Treatment Medication, Pimple Cream for Acne Prone Skin Care, 1 oz
- 1-ounce tube of Neutrogena Rapid Clear Stubborn Acne Spot Treatment Gel with maximum-strength 10% benzoyl peroxide acne medication to help fight acne and prevent future breakouts for clearer looking skin
- This effective acne-fighting spot gel is clinically proven to rapidly reduce the size and redness of stubborn acne in just 2 hours and actively fights breakouts, for continuous improvement in skin's appearance throughout the day
- Its maximum strength formula contains 10% benzoyl peroxide, the acne medication dermatologists recommend most for clearer skin without a prescription
- From a dermatologist recommended brand, this maximum-strength daily stubborn acne treatment is specially formulated for acne-prone skin to help manage acne and clear breakouts
- Cleanse skin thoroughly before applying acne pimple spot treatment gel then proceed to cover affected area with a thin layer of acne gel 1 to 3 times daily
$9.68
Differin Acne Treatment Gel, 30 Day Supply, Retinoid Treatment for Face with 0.1% Adapalene, Gentle Skin Care for Acne Prone Sensitive Skin, 15g Tube (Packaging May Vary)
- TARGETS ACNE: Clears breakouts where they start (Deep in pores) and prevents new acne from forming, which ultimately restores skin's texture and tone
- CLEARS, TREATS & PREVENTS: Differin works differently than other Acne treatments by normalizing skin cell turnover and effectively targets two primary causes of Acne, clogged pores and inflammation
- RX STRENGTH ACNE RETINOID: Adapalene was created for superior tolerability compared to other prescription retinoid products not containing Adapalene; It is suitable for use as part of your morning or evening regimen
- DERMATOLOGIST RECOMMENDED: Water based formula, oil free, alcohol free, fragrance free, non comedogenic; Helps reduce the risk of scarring and Hyperpigmentation by treating Acne
- REAL RESULTS: In a clinical study, Differin gel provided up to 87 percent reduction in acne breakouts after 12 weeks, which will continue to improve with further use
$14.97
Peach Slices | Deep Blemish Microdarts | Acne Patch | Early Stage & Deep Pimples | Salicylic Acid | Tea Tree Oil | Niacinamide | Cica | Hyaluronic Acid | 9 Patches
- Early Stage & Deep Pimples: The acne patches actively absorb developing blemishes or already-present pimples. These small, translucent sticker-like hydrocolloid patches act as a protective cover over the treated area to make the blemish visibly smaller in less than one day.
- Perfect for All Skin Types & Ages: These patches are drug-free, non-drying, and absorb secretions. Use on normal, dry, or oily skin. They are strong enough to stay on through the night and can be worn under makeup.
- Microdart Melt-Tech: Boasts 176 Microdarts (more than any other brand) that self-dissolve deep into the skin to deliver ingredients that precisely target stubborn blemishes. Our lab spent months perfecting the levels of sharpness — zero pain, but effective! — and adhesion to deliver you best-in-class innovation powered by science.
- Vegan & Cruelty-Free Formula: Our acne dots are made with a clean formula that is alcohol-free, does not contain harmful chemicals, is cruelty-free, and vegan friendly.
- Easy Application: Simple to use acne patches for the face. First, cleanse the skin area and place the patch over that spot. Remove the Microdart after 8 hours and then cleanse the area and apply another patch, if needed.
$8.88
TreeActiv Salicylic Acid Cystic Acne Spot Treatment, 0.5 fl oz, for Face and Body, Cream for Hormonal Acne, Teens & Adults
- Effectively Combats Cystic Acne: Our nature-powered cystic acne treatment uses Bentonite Clay, Sulfur, and Tea Tree Oil to effectively pull out and dry out stubborn cystic acne. It can also be used as an acne on buttocks treatment for women and men.
- Acne Spot Treatment for Face: With over 120 uses per 0.5oz container, this is a long-lasting solution for cystic acne treatment for the face and body, and for adult cystic acne treatment for women and men. It rids acne, whiteheads, and blackheads.
- Clears Cystic Acne On The Spot: Fast and noticeable results in just 20 minutes, this cystic acne overnight treatment is perfect for cystic acne treatment for sensitive skin and as a pimple cream spot treatment overnight use for face and body.
- Works For All Skin Types: Designed for sensitive skin, this cystic acne spot treatment for adults includes Aloe to soothe sensitive skin. This is vegan, cruelty-free, and free of parabens, making it a perfect spot treatment for cystic pimples.
- Try Our Acne Skin Care Regimen: 5 Step Acne Treatment Kit - Acne Face Wash, Acne Face Cream, Salicylic Acid Acne Toner, Acne Face Scrub, and Acne patches. Also, try our salicylic acid spot treatment and acne scar treatment for face consistently.
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Murad Rapid Relief Acne Spot Treatment – Acne Control Max Strength 2% Salicylic Acid Invisible Gel Spot Solution for Fast Acne Relief - Reduces Blemish Size and Redness Within 4 Hours, 0.5 Oz
- RAPID BLEMISH CONTROL: Murad's Rapid Relief Acne Spot Treatment fights blemishes, breakouts, and pimples at the source with 2% Salicylic Acid. This is the highest concentration of acne fighting solution in the Murad Acne Control Collection that led 97% of study participants to agree that blemish appearance improved after just 1 day in a Murad sponsored study.
- FORMULATED TO DELIVER RELIEF: This solution is formulated to reduce blemish size and redness within 4 hours of application. The Salicylic Acid works to exfoliate and clear pores, while smoothing the skin, returning it’s natural glow. Inspired by natural Pine and Thyme Extracts, the patented complex fights irritants while preserving the skin's healthy balance.
- WORKS SEAMLESSLY WITH YOUR MAKEUP: This clear gel formula layers under your concealer of choice without peeling or flaking for flawless treatment even on the toughest acne flares. It won't pile or peel under your makeup, so you can conceal your acne spots and go on with your day, confidently.
- WHAT ELSE DO I NEED?: Rapid Relief Acne Spot Treatment works as a treatment solution in any Murad Acne regimen as part of Dr. Murad's inclusive health system of care. Pair with Murad's Clarifying Cleanser, Acne Clearing Solution, and Oil-Control Mattifier for optimal results.
- IT'S NOT SKINCARE, IT'S MURAD: Murad is founded on the simple truth that living younger is a choice you can make every day. 25 years ago Dr. Howard Murad founded the first modern doctor brand of clinical skincare products, with a goal of making beautiful, healthy skin attainable for everyone. He has changed how the world sees skincare through his pioneering research and a Connected Beauty philosophy.
$26.00
Cystic Acne Spot Treatment Cream for Face, Back and Body, Hormonal Pimple Scar Moisturizer Gel for Teens & Adults, Rapid Control and Clear Breakouts, 1.8 oz
- SAY BYE-BYE TO ACNE BREAKOUTS: Fast-clearing solution for stubborn acne spots with maximum strength 10% azelaic acid to treat acne deep within existing pores while preventing new ones from forming
- VARIOUS BENEFITS FOR ACNE-PRONE SKIN: This hormonal acne treatment cream effectively tackles cystic, hormonal, and severe acne. Targets various skin problems such as body and back acne, redness, whiteheads, excess oil, enlarged pores, etc
- NATURAL AND GENTLE FORMULA: Contains salicylic acid, tea tree oil, niacinamide and a variety of other natural active ingredients. Passed allergy test, no burning sensation, balances oil levels, gently works on acne
- IMPROVED PACKAGING: The new bottle is designed with a push pump for easy use. It has a large capacity that can be used for a long time. The airtight design keeps this hydrating anti-acne cream fresh and soft
- HOW TO USE: After cleansing and toning, apply a generous amount of cystic acne cream onto acne and wash off overnight. Do not apply to a large area and avoid the area around the eyes. Use 1-2 times a day, 2-3 times for severe acne for 4 weeks at least
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SALE
−$8.71
Proactiv Emergency Blemish Relief Benzoyl Peroxide Gel Acne Spot Treatment for Face and Body, white, 0.33 Oz
- EMERGENCY RELIEF: This invisible benzoyl peroxide spot treatment contains a powerful dose of microcrystal benzoyl peroxide to target acne-causing bacteria inside pores to clear up acne blemishes.
- YOU NEED MORE THAN A PIMPLE CREAM: Proactiv's benzoyl peroxide acne treatment is designed to unclog pores and is specially formulated to help absorb excess oil and clear emergency blemishes fast.
- PERFECT FOR ON THE GO: Unexpected blemishes can happen any time, so this pocket-sized spot treatment can go wherever you do.
- SAFE FOR ALL AGES: Proactiv's acne skin care treatment provides the same powerful skin care for teens and adults.
- MADE FOR YOUR SKIN: Proactiv Solution delivers benzoyl peroxide microcrystals deep into your pores to help stop acne-causing bacteria in its tracks and prevent new breakouts from forming.
$13.29
SALE
−$5.60
AcneFree Terminator 10 Acne Spot Treatment with Benzoyl Peroxide 10% Maximum Strength Acne Cream Treatment, 1 Ounce - Pack Of 2
- The information below is per-pack only
- Redness Control Cream
- Dermatologist recommended
- Eliminate acne bacteria.
$10.38
Last update on 2025-05-02 / Affiliate links / Images from Amazon Product Advertising API