Spot treatment for acne is essential for anyone looking to quickly reduce breakouts and promote clearer skin. In 2025, the market offers a variety of effective options, ranging from salicylic acid gels to natural remedies like tea tree oil. These treatments target blemishes directly, helping to minimize inflammation and speed up healing. With advancements in skincare technology, many products now include additional ingredients that nourish the skin while combating acne, making them a must-have in your skincare routine.
SALE
−$4.00
Neutrogena On-The-Spot Acne Treatment Gel with Benzoyl Peroxide - Gentle Face Acne Medicine for Acne Prone Skin, 0.75 oz
- .75-ounce tube of Neutrogena On-The-Spot Acne Spot Treatment cream with benzoyl peroxide to fight acne while gentle on skin
- Vanishing cream formula of this acne spot treatment is lightweight, absorbs quickly and works invisibly hour after hour to give long-lasting acne treatment
- On-The-Spot treatment is clinically proven to be so effective that skin starts getting clearer on day 1 to without over-drying, stinging or burning skin
- This gentle daily acne blemish treatment can be used up to three times a day. It's formulated with 2.5% benzoyl peroxide acne medicine, to help treat and prevent acne
- The acne-fighting formula goes deep down into pores to kill acne bacteria that causes pimples and helps stop new ones from forming
$7.99
SALE
−$3.71
Neutrogena Rapid Clear Stubborn Acne Spot Treatment Gel with Maximum Strength 10% Benzoyl Peroxide Acne Treatment Medication, Pimple Cream for Acne Prone Skin Care, 1 oz
- 1-ounce tube of Neutrogena Rapid Clear Stubborn Acne Spot Treatment Gel with maximum-strength 10% benzoyl peroxide acne medication to help fight acne and prevent future breakouts for clearer looking skin
- This effective acne-fighting spot gel is clinically proven to rapidly reduce the size and redness of stubborn acne in just 2 hours and actively fights breakouts, for continuous improvement in skin's appearance throughout the day
- Its maximum strength formula contains 10% benzoyl peroxide, the acne medication dermatologists recommend most for clearer skin without a prescription
- From a dermatologist recommended brand, this maximum-strength daily stubborn acne treatment is specially formulated for acne-prone skin to help manage acne and clear breakouts
- Cleanse skin thoroughly before applying acne pimple spot treatment gel then proceed to cover affected area with a thin layer of acne gel 1 to 3 times daily
$9.68
SALE
−$2.80
AcneFree Terminator 10 Acne Spot Treatment with Benzoyl Peroxide 10% Maximum Strength Acne Cream Treatment, 1 Ounce - Pack Of 1
- Severe Acne Spot Treatment: Maximum strength, 10% Benzoyl Peroxide fights severe acne and prevents new acne from forming. Dermatologist developed and tested; Oil free and fragrance free
- Reduces Redness and Soothes: Ginger is an effective treatment for acne, fighting active blemishes and treating skin until cleansing while Chamomile soothes
- Healthy Skin Solutions: We carry a full line of treatment kits, cleansers, moisturizers, detox masks, scrubs, creams, toners and other targeted solutions for sensitive, oily and acne prone skin
- Dermatology Inspired Care: Our products offer hydration, soothing, detoxifying and mattifying benefits to help ensure your skin looks and feels healthy and help maintain your skin’s balance with consistent use
- Dermatologist Recommended: Built on a foundation of dermatological science and research, doctors consistently recommend our products to men, women, teens and adults in need of gentle yet effective acne treatment
$5.19
Differin Acne Treatment Gel, 30 Day Supply, Retinoid Treatment for Face with 0.1% Adapalene, Gentle Skin Care for Acne Prone Sensitive Skin, 15g Tube (Packaging May Vary)
- TARGETS ACNE: Clears breakouts where they start (Deep in pores) and prevents new acne from forming, which ultimately restores skin's texture and tone
- CLEARS, TREATS & PREVENTS: Differin works differently than other Acne treatments by normalizing skin cell turnover and effectively targets two primary causes of Acne, clogged pores and inflammation
- RX STRENGTH ACNE RETINOID: Adapalene was created for superior tolerability compared to other prescription retinoid products not containing Adapalene; It is suitable for use as part of your morning or evening regimen
- DERMATOLOGIST RECOMMENDED: Water based formula, oil free, alcohol free, fragrance free, non comedogenic; Helps reduce the risk of scarring and Hyperpigmentation by treating Acne
- REAL RESULTS: In a clinical study, Differin gel provided up to 87 percent reduction in acne breakouts after 12 weeks, which will continue to improve with further use
$14.97
SALE
−$3.02
CeraVe Acne Control Gel, 2% Salicylic Acid Treatment With Glycolic Acid + Lactic Acids + Niacniamide, Acne Gel Helps Clear Blemishes Without Over Drying, Alcohol Free & Oil Free, 1.35 Fl Oz
- [ACNE TREATMENT WITH BHA/AHA EXFOLIANT] Formulated with 2% salicylic acid and a blend of glycolic acid and lactic acid, this acne spot treatment for face helps clear acne and prevent new breakouts, acting as an effective face exfoliator.
- [PORE MINIMIZER FOR FACE] This acne skincare product minimizes the appearance of pores and reduces blackheads with its potent mix of niacinamide and hyaluronic acid, enhancing skin moisture and soothing properties.
- [ALCOHOL FREE & HYDRATING GEL] Free from fragrance, parabens, and oil, this non-comedogenic acne spot treatment is designed without harsh alcohols, preventing excessive dryness while treating stubborn acne effectively.
- [ 3 ESSENTIAL CERAMIDES ] Ceramides are found naturally in the skin and make up 50% of the lipids in the skin barrier. All CeraVe products, formulated with three essential ceramides (1, 3, 6-II)to help maintain the skin’s natural barrier.
- [ DEVELOPED WITH DERMATOLOGISTS ] CeraVe Skincare is developed with dermatologists and has products suitable for dry skin; sensitive skin; oily skin; acne-prone; and more. FSA Eligible & HSA Eligible Acne Skin Care
$17.97
SALE
−$8.71
Proactiv Emergency Blemish Relief Benzoyl Peroxide Gel Acne Spot Treatment for Face and Body, white, 0.33 Oz
- EMERGENCY RELIEF: This invisible benzoyl peroxide spot treatment contains a powerful dose of microcrystal benzoyl peroxide to target acne-causing bacteria inside pores to clear up acne blemishes.
- YOU NEED MORE THAN A PIMPLE CREAM: Proactiv's benzoyl peroxide acne treatment is designed to unclog pores and is specially formulated to help absorb excess oil and clear emergency blemishes fast.
- PERFECT FOR ON THE GO: Unexpected blemishes can happen any time, so this pocket-sized spot treatment can go wherever you do.
- SAFE FOR ALL AGES: Proactiv's acne skin care treatment provides the same powerful skin care for teens and adults.
- MADE FOR YOUR SKIN: Proactiv Solution delivers benzoyl peroxide microcrystals deep into your pores to help stop acne-causing bacteria in its tracks and prevent new breakouts from forming.
$13.29
Murad Rapid Relief Acne Spot Treatment – Acne Control Max Strength 2% Salicylic Acid Invisible Gel Spot Solution for Fast Acne Relief - Reduces Blemish Size and Redness Within 4 Hours, 0.5 Oz
- RAPID BLEMISH CONTROL: Murad's Rapid Relief Acne Spot Treatment fights blemishes, breakouts, and pimples at the source with 2% Salicylic Acid. This is the highest concentration of acne fighting solution in the Murad Acne Control Collection that led 97% of study participants to agree that blemish appearance improved after just 1 day in a Murad sponsored study.
- FORMULATED TO DELIVER RELIEF: This solution is formulated to reduce blemish size and redness within 4 hours of application. The Salicylic Acid works to exfoliate and clear pores, while smoothing the skin, returning it’s natural glow. Inspired by natural Pine and Thyme Extracts, the patented complex fights irritants while preserving the skin's healthy balance.
- WORKS SEAMLESSLY WITH YOUR MAKEUP: This clear gel formula layers under your concealer of choice without peeling or flaking for flawless treatment even on the toughest acne flares. It won't pile or peel under your makeup, so you can conceal your acne spots and go on with your day, confidently.
- WHAT ELSE DO I NEED?: Rapid Relief Acne Spot Treatment works as a treatment solution in any Murad Acne regimen as part of Dr. Murad's inclusive health system of care. Pair with Murad's Clarifying Cleanser, Acne Clearing Solution, and Oil-Control Mattifier for optimal results.
- IT'S NOT SKINCARE, IT'S MURAD: Murad is founded on the simple truth that living younger is a choice you can make every day. 25 years ago Dr. Howard Murad founded the first modern doctor brand of clinical skincare products, with a goal of making beautiful, healthy skin attainable for everyone. He has changed how the world sees skincare through his pioneering research and a Connected Beauty philosophy.
$26.00
Mighty Patch™ Original patch from Hero Cosmetics - Hydrocolloid Acne Pimple Patch for Covering Zits and Blemishes in Face and Skin, Vegan-friendly and Not Tested on Animals (36 Count)
- The Original Award-Winning Acne Patch: Mighty Patch Original patch is a hydrocolloid sticker that improves the look of pimples overnight without the popping. Just stick it on, get some sleep, and wake up with clearer-looking skin.
- Results in 6-8 Hours: Absorbs pimple gunk thanks to our medical-grade hydrocolloid. Clinically tested, drug-free, and safe for all skin types.
- All-Night Adhesion: Strong enough to stay on through a whole night of tossing, turning, and pillow-squishing. Easy to remove in the AM without redness or irritation.
- Blends Seamlessly into Skin: The thin sticker with a translucent matte finish keeps your pimple under wraps day or night. You might just forget you’re even wearing it.
- Peace-Of-Mind Design: Our hydrocolloid patches are UV sterilized, and allergy tested. Each box comes with 36 medium dots (12 millimeters) on easy-peel perforated sheets.
$12.99
Differin Acne Spot Treatment with 10% Benzoyl Peroxide, Maximum Strength OTC Acne Treatment, Fast Acting Spot Treatment for Face, 1 oz
- MAXIMUM STRENGTH 10% BENZOYL PEROXIDE: One 1 oz tube of Differin Acne Spot Treatment with 10% benzoyl peroxide as the strongest over-the-counter (OTC) concentration to visibly reduce acne size and redness after 1 use.
- FAST BLEMISH SPOT TREATMENT: Penetrates deep into pores and works to immediately kill acne-causing bacteria
- FOUR-IN-ONE ACNE TREATMENT FOR FACE: Acne solution that treats imperfections, prevents acne, targets acne-causing bacteria, and improves skin texture
- FORMULATED WITH GLYCERIN: While benzoyl peroxide starts clearing acne blemishes, glycerin helps to minimize dryness
- HOW TO USE: After cleansing with a gentle face wash, apply spot treatment on dry skin directly on affected areas, followed by moisturizer and SPF, and reapply as needed
$9.97
Last update on 2025-05-01 / Affiliate links / Images from Amazon Product Advertising API