Saline nasal spray is an essential product for maintaining nasal health, especially during allergy season or cold months. The best saline nasal sprays effectively moisturize dry nasal passages, relieve congestion, and help clear out allergens and irritants. In 2025, the market offers a variety of options that cater to different needs, from those designed for infants to those with added ingredients for enhanced relief. Choosing the right saline nasal spray can make a significant difference in your comfort and overall respiratory health.
Arm & Hammer Simply Saline Daily Care Nasal Mist 4.4oz, Saline Nasal Spray, Drug-Free, 2-Pack
- Starts working in seconds!
- Helps relieve dryness
- Moisturizes and helps flush irritants from nasal passages
- A drug-free nasal spray that contains no steroids, made with simple and safe ingredients such as purified water, salt, and ARM & HAMMER Baking Soda
- Safe to use day and night, during pregnancy, and doctor-recommended for use with prescription and OTC medications
$14.79
Amazon Basic Care Premium Saline Nasal Moisturizing Spray, 1.5 fl oz (Pack of 1), Clear
- COMPARE AND SAVE: Compare to the ingredients in Ocean. Amazon Basic Care Premium Saline Nasal Moisturizing Spray contains sodium chloride 0.65%, phenylcarbinol and benzalkonium chloride as preservatives.
- SOOTHES DRY NASAL PASSAGES: This saline nasal spray relieves dry nasal membranes.
- SALINE NASAL SPRAY provides non-medicated relief for irritated and dry nasal passages.
- RELIEVES DRYNESS from allergy, sinus and cold medications. Instantly soothes dry nasal passages.
- CAUTION: Keep Amazon Basic Care Premium Saline Nasal Moisturizing Spray out of reach of children. The use of this nasal moisturizing spray dispenser by more than one
$4.00
ARM & HAMMER Simply Saline Nasal Care Daily Mist 4.5oz – Instant Relief for Every Day Congestion – One 4.5oz Bottle
- ARM & HAMMER Simply Saline Daily Care Nasal Mist 4.5 oz (127 g) saline nasal spray provides instant relief for everyday nasal congestion while gently cleansing and moisturizing dry noses
- This fast-acting saline nose spray helps naturally moisturize dry nasal passages and and clear congestion associated with year-round allergies or colds; it gently flushes out mucus, dust, pollen, and other irritants to help you breathe easier
- Safe for pregnant women and adults, this drug-free nasal spray is free of fragrances, dyes, artificial flavors, and parabens; it’s made with 3 simple, pure ingredients: purified water, salt, and real ARM & HAMMER Baking Soda
- This saline nasal spray provides instant congestion relief to help you breathe easy and keeps nasal passages well-moisturized to help prevent dry nosebleeds; also helps relieve blocked nasal passages to promote better sleep and sports activity
- This drug-free nasal spray saline solution delivers a comforting mist that contains no steroids; its isotonic formula safely soothes and helps clear nasal passages without causing any drowsiness or side effects
$8.54
Mucinex Sinus Saline Nasal Spray & Sinus Rinse, Drug-Free, Additive Free, Non-Drowsy Nasal Irrigation with 2-in-1 Jet + Mist Spray Nozzle for Cold & Allergy Season, 4.5oz
- SALINE NASAL SPRAY: Mucinex Sinus Saline Nasal spray is designed to help clear congestion associated with colds & year-round allergies; Our unique 2-in-1 nozzle features a powerful jet for tough congestion & a gentle mist for everyday congestion
- SINUS RINSE: A saline nasal rinse that's non-medicated, non-drowsy, has no additives & is safe for daily use for adults & children 2 years of age and older
- NASAL IRRIGATION SYSTEM: A powerful solution for clearing nasal congestion; Our saline spray is formulated to soothe and moisturize your sinuses, providing effective relief; Breathe easy and conquer sinus congestion today
- OVER-THE-COUNTER SALINE SOLUTION: Targeted relief meets soothing moisture in every spray; Elevate your sinus care routine and enjoy the revitalizing benefits of our saline solution
- TRUSTED BRAND: Mucinex is the #1 Cough & Cold Brand Doctor's Trust* and is also the #1 Pharmacist Recommended Brand**; Get the brand that doctors trust and recommend
$8.99
SinuCleanse Daily Care Sterile Saline Nasal Spray, Ultra Fine Mist, Instantly Moisturizes & Relieves Everyday Nasal Congestion Due to Colds & Dry Air, 4.5 Oz (2 Pack), Made in USA
- SinuCleanse Daily Care Sterile Saline Nasal Mist: Moisturizes and provides fast, all natural, preservative free relief of nasal congestion and sinus symptoms associated with colds, allergies, dry air and other nasal irritants
- Breathe Easier: SinuCleanse Daily Care Nasal Mist instantly moisturizes dry nasal passages and aids in the removal of mucus, allergens and other debris that can cause nasal congestion & discomfort
- Safe To Use As Often As Needed: SinuCleanse Nasal Mists can be used by all ages and as often as needed for every day relief
- Doctor Recommended: SinuCleanse Daily Care Sterile Saline Mist can be used with prescriptions and over the counter cold & allergy medications without the worry of side effects or interactions
- Made in USA and FDA Registered: All SinuCleanse nasal mist products are proudly manufactured in the USA in a FDA Registered Drug Facility to ensure safety and efficacy
$11.99
Vicks Sinex SALINE Nasal Spray, Drug Free Ultra Fine Mist, Clear Everyday Sinus Congestion Fast, Clear Mucus from a Cold or Allergy, Daily Use 5.0 fl oz x 2
- Instantly clear everyday congestion and moisturize dry, stuffy noses
- Drug-free nasal saline spray provides relief from congestion caused by a cold or allergy spell!
- Safe for daily use because it does not contain any nasal decongestant medicine! Just a hypertonic saline solution made with purified water and no added preservatives
- Help clear your sinuses from every day nasal congestion with fast, drug-free relief
- The ultra-fine saline mist instantly soothes and moisturizes dry nostrils for dry nose relief
$20.38
Thera Care Nasal Spray | Premium Saline | 1.5 fl oz | Non-Medicated Solution | Safe for Adults and Children | Allergy Relief
- SOOTHING NASAL RELIEF — Provides immediate relief for dry and irritate nasal passages
- RELIEVES DRY NASAL CAVITIES — Saline (salt water) restores moisture; spray bottle helps ensure even and thorough application in the nose
- EASES INFLAMATION AND IRRITATION — Saline solution soothes inflammation of the mucus membranes that line sinuses
- ALLERGY AID—Nasal washes help flush pollen, dust and debris from nasal passages
- SUPPORT AND INSTRUCTION — Follow the detailed use instructions, as well as the warnings and cautions, before use; use only as directed, instructions are easy to follow and use
$1.99
SALE
−$0.50
MAJOR Deep Sea Premium Saline - Nasal Moisturizing Spray for Dryness and Irritation Relief - Sodium Chloride 0.65% - 1.5 Fl. Oz (3 Pack)
- NASAL SPRAY FOR DRY NOSE: Major's Sodium Chloride 0.65% Nasal Spray is a trusted remedy for temporary relief from nasal dryness due to allergy, cold, and sinus medicines.
- INGREDIENTS: Our spray is formulated with 0.355 mg of sodium. It is free from animal by-products, starch, dyes, alcohol, gluten, and nuts.
- QUALITY FORMULATION: We maintain high standards of care through strict regulatory compliance to deliver carefully formulated, effective nasal spray. With a 0.65% sodium chloride formula, our nose spray offers non-medicated relief for dry, irritated noses.
- HOW TO USE: Squeeze twice into each nostril as needed. With three different spray options- upright for a spray, horizontally for a stream, and upside down for a drop- our daily nasal spray provides tailored relief for your specific needs.
- MAJOR PHARMACEUTICALS: At Major Pharmaceuticals, we believe wellness should be accessible to everyone. We pride ourselves on our legacy of delivering quality OTC and vitamin supplements.
$6.45
SALE
−$1.26
Little Remedies Sterile Saline Nasal Mist, Safe for Newborns, 3 oz
- Little Remedies Sterile Saline Nasal Spray temporarily relieves stuffy, dry, or crusty noses and keeps baby's nose clear and moisturized
- Baby saline nasal spray flushes mucus from little ones’ noses
- Nasal saline spray contains no alcohol and is drug- and preservative-free
- Non-medicated sinus rinse that safely soothes children's cold and allergy symptoms; Safe for newborns
- Contains 1 can of Little Remedies Baby Medicine, Sterile Saline Nasal Spray for Baby and Newborn, 3 Oz; FSA- and HSA-eligible product in the U.S.
$4.73
SALE
−$9.87
Simply Saline Adult Nasal Mist, Original, Pack of 3, 4.25 Oz Each
- Simply saline Nasal Spray helps deliver instant congestion relief by flushing out irritants. It's Adaptable nozzle and gentle mist make it easy to use. Plus, simply saline is always safe to pair with your cold or allergy medicine because it's drug free, preservative free, steroid free, and non-addictive. In fact, it's made from three simple ingredients: Water, salt, and arm & Hammer baking soda
- Moisturizes & helps clear congestion.
- Preservative & Drug free.
- Remains sterile throughout use
- Does not damage delicate nasal tissue contains no CFC's
$20.13
Last update on 2025-05-01 / Affiliate links / Images from Amazon Product Advertising API