Runny nose medicine is essential for alleviating the discomfort associated with colds and allergies. In 2025, several products stand out for their effectiveness and user satisfaction. These medications range from antihistamines to decongestants, each designed to target specific symptoms and provide relief. Whether you prefer over-the-counter options or natural remedies, there are top-rated choices available to help you breathe easier and feel better.
SALE
−$1.19
Boiron ColdCalm Tablets for Relief of Common Cold Symptoms Such as Sneezing, Runny Nose, Sore Throat, and Nasal Congestion - Non-Drowsy - 60 Count
- MULTI-SYMPTOM COLD RELIEF: ColdCalm Tablets relieve common cold symptoms, including sneezing, runny nose, nasal congestion, and minor sore throat, at every stage of the cold.* Non-drowsy relief with no known drug interactions for ages 4 and up.
- MELTAWAY CONVENIENCE: ColdCalm Tablets dissolve easily in the mouth without the need for water, chewing or swallowing, so you can act fast against cold symptoms anywhere, anytime.
- HELP YOUR BODY THE NATURAL WAY: This homeopathic cold medicine is non-drowsy and non-habit forming and can be taken day or night. It’s also gluten-free and contains no artificial sweeteners, flavors, colors, or preservatives.
- A TRUSTED BRAND: With more than 90 years of expertise, Boiron medicines are manufactured to meet the highest standards of cGMP and HPUS for purity and quality.
- BUY WITH YOUR HSA/FSA: Many of your favorite Boiron medicines are now eligible for reimbursement. Look for our logo designating products that can be paid for with your Health Savings Account or Flexible Savings Account.
$9.99
SALE
−$2.49
Sudafed PE Sinus Congestion Day + Night Maximum Strength Decongestant & Antihistamine Tablets with Phenylephrine HCl & Diphenhydramine HCl, Helps Nasal & Sinus Pressure & Congestion, 20 ct
- 20-count of Sudafed PE Sinus Congestion Day + Night Maximum Strength Decongestant Medicine Tablets to temporarily relieve sinus pressure and sinus congestion for both day and night
- Each multi-pack contains 20 tablets of nasal decongestant, with 12 Daytime and 8 Nighttime tablets for powerful symptom relief throughout the day and while you sleep
- Each daytime and nighttime dose contains 10 milligrams of the nasal decongestant phenylephrine HCl per tablet and each nighttime dose also contains 25 milligrams per tablet of the antihistamine diphenhydramine HCl
- Both formulas help relieve sinus pressure and sinus congestion, and nasal congestion due to the common cold, hay fever, or upper respiratory allergies. Nighttime tablets also relieve sneezing, runny nose, itchy, watery eyes and itchy throat or nose
- From the #1 pharmacist recommended brand among oral OTC decongestants, this maximum-strength formula can be used by adults and children 12 years and older for powerful symptom relief
$8.18
SALE
−$2.95
Mucinex Sinus-Max Max Strength Day & Night Liquid Gels 24 ct
- MAXIMUM STRENGTH MUCINEX SINUS-MAX DAY: Helps relieve pain, sinus pressure, headache, nasal and chest congestion and thins and loosens mucus
- MAXIMUM STRENGTH MUCINEX SINUS-MAX NIGHT: Helps relieve pain, sinus pressure, nasal congestion, cough, and runny nose and sneezing
- TRUSTED COLD and COUGH BRAND: Cold and Cough brand doctors trust
- ACTIVE INGREDIENTS IN DAY: Contains Acetaminophen for pain relief, Dextromethorphan HBr for cough suppression, Guaifenesin as an expectorant and Phenylephrine HCl for nasal decongestion
- ACTIVE INGREDIENTS IN NIGHT: Contains Acetaminophen for pain relief, Dextromethorphan HBr for cough suppression, Doxylamine Succinate as an Antihistamine and Phenylephrine HCl for nasal decongestion
$15.54
SALE
−$2.63
Alka-Seltzer Plus Maximum Strength Power Max Sinus, Allergy and Cough Medicine for Adults and Children 12 Years and Older - Relieves Symptoms from Allergies, Colds or Hay Fever, 24 Count
- Alka-Seltzer Plus Maximum Strength Powermax gels provide powerful allergy and sinus relief *Use as directed.
- Get the fast, effective relief from colds, hay fever, and allergy symptoms when you need it.
- ASP Sinus, Allergy & Cough medicine contains a pain reliever / fever reducer, cough suppressant, antihistamine and a nasal decongestant.
- This sinus, allergy, and cough medicine contains an antihistamine which helps to reduce allergy symptoms like sneezing, runny nose, and itchy/watery eyes.
- This Sinus, Allergy & Cough relief medicine also contains cough suppressant and nasal decongestant to help relieve cough, nasal congestion, sinus congestion and pressure.
$7.86
SALE
−$2.03
Benadryl Liqui-Gels Allergy Medicine, Dye-Free Liquid Gel Capsules with 25 mg of Diphenhydramine HCl Antihistamine for Relief of Allergy & Cold Symptoms Like Runny Nose & Sneezing, 24 ct
- ALLERGY RELIEF MEDICATION: 24-count package of Benadryl Dye-Free Allergy Relief Liquid Gels to help alleviate symptoms associated with allergies such as sneezing, runny nose, itchy throat or nose, and itchy, watery eyes
- POWERFUL ANTIHISTAMINE: This allergy medicine temporarily provides relief of hay fever and other upper respiratory symptoms such as sneezing and runny nose. It also provides relief from common allergens such as tree pollen, dust, mold and pet dander
- COLD SYMPTOM RELIEF: The antihistamine tablets with diphenhydramine hydrochloride feature an effective and powerful formula that works when you need it most. The tablets for multi-symptom relief help tackle both cold and allergy symptoms
- DYE-FREE DIPHENHYDRAMINE HCl FORMULA: Made with a dye free formula, Benadryl allergy medicine contains 25 mg diphenhydramine hydrochloride, an antihistamine that works to help provide allergy and upper respiratory relief
- POWERFUL ALLERGY & COLD SYMPTOM RELIEF IN JUST 1 PILL: Adults & children 12+, take one to two allergy liquid gels every four to six hours. Children ages 6-12, take one allergy medicine tablet every four to six hours. Do not give more than 6 doses in 24 hours
$6.99
Contac Non-Drowsy Day & Multi-Symptom Night Cold & Flu Medicine, Maximum Strength Relief for Fever, Sore Throat, Nasal Congestion, Head & Body Aches, Runny Nose, 28 Count, 16 Day, 12 Night Caplets
- FAST-ACTING, MAXIMUM-STRENGTH RELIEF: Get 24-hour relief from common cold & flu symptoms, including nasal congestion, sinus congestion and pressure, sore throat, head & body aches and fever, runny nose, and sneezing
- NON-DROWSY, DAYTIME RELIEF: Our severe cold & flu medicine provides symptom relief without making you drowsy; Stay alert and active throughout your day
- NIGHTTIME COMFORT: Sleep better with our nighttime formula that eases symptoms for restful sleep
- 24-HOUR RELIEF: Feel better and stay alert by using our daytime formula with Phenylephrine HCI a nasal decongestant to ease congestion and acetaminophen a pain reliever/fever reducer to relieve minor aches, pains and sore throat; get some rest at night with our nighttime formula that also contains Chlorpheniramine maleate an antihistamine to ease your symptoms overnight
- FIGHT THE FLU & COLD: Contac Cold + Flu tackles severe cold & flu symptoms for adults and children 12 years and older; FSA/HSA eligible, gluten-free and no artificial colors
$8.49
Coricidin HBP Decongestant-Free Cough and Cold Medicine - Specially Designed Relief for High Blood Pressure, Cough, Runny Nose, Sneezing and Cold Symptoms (16 Count)
- The no.1 brand that gives powerful cold symptom relief without raising your blood pressure
- Provides fast, powerful cold relief for people with high blood pressure
- Cold and cough medicine for adults that relieves cough, runny nose, and sneezing
- Decongestant free, cough cold medicine
- Cold medicine comes in tablet form
$8.99
SALE
−$2.52
Vicks Sinex SEVERE Nasal Spray, Original Ultra Fine Mist, Decongestant Medicine, Relief from Stuffy Nose due to Cold or Allergy, & Nasal Congestion, Sinus Pressure Relief, 265 Sprays x 2
- Targets nasal congestion and sinus pressure at the source by reducing swelling in the sinuses
- Breathe better all day or all night long with Vicks Sinex Severe. For instant, 12-hour, nasal congestion and sinus pressure relief
- This powerful decongestant medicine be used to treat severe sinus congestion and pressure caused by a cold or seasonal allergy spell, Not intended for daily use
- Unlike nasal decongestant tablets, Vicks Sinex Severe Nasal Sprays works by delivering powerful decongestant medicine directly to your nasal membranes
- Vicks Sinex Severe Nasal Spray is HSA and FSA eligible, Check with your provider for more details
$14.97
SALE
−$0.50
Boiron SinusCalm Tablets for Sinus Pain Relief, Runny Nose, Congestion, Sinus Pressure, Headache - 60 Count
- Targets sinus pain with a stuffy or runny nose.
- Non-drowsy and won't mask symptoms of a more serious condition
- Homeopathic multi-symptom sinus Relief medicine, non-habit forming and no risk of a rebound effect
- Slightly sweet pellets melt under the tongue without water, chewing, or swallowing pills. Pellets can also be dissolved in water for children or seniors. Recommended for everyone ages 6 and up.
- Available over the counter in a box of two multidose tubes for home or on the go (approximately 80 oral pellets per tube)
$10.49
Last update on 2025-05-02 / Affiliate links / Images from Amazon Product Advertising API