Pancreatic enzyme supplements are essential for individuals seeking to improve digestion and nutrient absorption, especially those with pancreatic insufficiency. In 2025, the market offers a variety of top-rated options that cater to different dietary needs and preferences. These supplements are formulated to provide a balanced blend of enzymes, including amylase, lipase, and protease, to support optimal digestive health. When choosing the right supplement, it's important to consider factors such as enzyme potency, ingredient quality, and customer reviews. Here are some of the best pancreatic enzyme supplements available today.
Vital Nutrients Pancreatic Enzymes 1000mg (Full Strength) | Pancreatin Digestion Supplement with Protease, Amylase & Lipase | Digestive Enzymes | Gluten, Dairy, and Soy Free | 90 Capsules
- Premium Digestive Enzyme Supplement: Supports gut health, digestion, and bowel regularity with one easy-to-swallow capsule taken with meals. Helps support relief from occasional indigestion, gas, and bloating*
- Full-Strength Pancreatic Enzymes For Humans Healthy Digestion: Lactose-free pancreatin includes protease, lipase enzymes, and amylase enzymes to support digestion and nutrient absorption from protein, fats, and carbohydrates*
- Clean Formula: Free from gluten, dairy, peanut, tree nut, fish, shellfish, soy, sesame, and egg. Non-GMO. Made without artificial fillers, coatings, binders, or colors.
- Quality You Can Rely on: Vital Nutrients supplements are manufactured in our allergen-free, NSF-certified Middletown, CT facility. Our rigorous quality assurance program includes third-party independent laboratory testing of raw ingredients and finished products for purity and potency to ensure what’s on the label matches what’s in the bottle
- Trusted by Healthcare Practitioners Worldwide: Vital Nutrients was founded 30 years ago by practitioners who set out to make a positive and lasting impact on the health of people and planet. Today, our premium line of clinically relevant, pure, clean-label formulas is trusted by healthcare practitioners and health-conscious consumers worldwide
$39.90
SALE
−$16.00
NOW Foods Supplements, Pancreatin 2000 with naturally occurring Protease (Protein Digesting), Amylase (Carbohydrate Digesting), and Lipase (Fat Digesting) Enzymes, 250 Capsules
- DIGESTIVE SUPPORT: Pancreatin has naturally occurring protease (protein digesting), amylase (carbohydrate digesting), and lipase (fat digesting) enzymes.
- ASSISTS PROTEIN, FAT, AND CARBOHYDRATE DIGESTION: Pancreatin is a preparation of porcine pancreatic enzymes.
- CERTIFICATIONS/CLASSIFICATIONS: Keto Friendly, Soy Free, Nut Free, Made without Gluten, Dairy Free, Egg Free
- Digestive
- Family Owned Since 1968
$19.99
SALE
−$8.06
Pancreatin Digestive Enzymes Digestion for Gut Health - Pancreatic Digestive Enzymes for Women & Men with Protease, Lipase & Amylase - Bloating, Stomach Health, Fat, Carb & Protein - 60 Count
- Pancreatin 4X - This proven combination of pure digestive enzymes for pancreas support and digestive health helps break down the main building blocks of food to keep your body functioning at its best
- Simple but Effective Digestion Supplement - Pancreatic enzyme supplements work by supplementing the body’s natural enzyme supply to ensure nutrient absorption and digestion to help prevent blockages
- 3 in 1 Formula - The amylase enzyme is to help digest carbs and minimize related bloating The lipase enzyme is for digesting fats and the protease enzyme supplement is for breaking down proteins
- Trusted Brand - Forget about generic brands and put your trust in Natures Craft and our 3rd party lab tested digestive enzyme supplements made in GMP American facilities with non GMO ingredients
- Natures Craft Quality - We are proud to be a leading name in a variety of potent digestion and digestive enzymes for men and women because we know just how important gut health can be for adults
$10.49
Pure Encapsulations Pancreatic Enzyme Formula - Digestive Enzymes for Digestion - Strengthens Gut Health* - Targeted Delivery Capsules - Gluten Free & Non-GMO - 60 Capsules
- Digestive Enzyme Blend for Gut Health: Contains amylase enzyme, lipase enzyme, and protease enzyme supplement to support natural digestion*
- Targeted Delivery Capsules: Acid-resistant capsules ensure enzymes for digestion—including our protease, amylase, and lipase—reach the G.I. tract*
- Concentrated Pancreatin: Each capsule provides 500 mg of pancreatin for digestive function support, strengthening gut health and aiding digestion*
- Suggested Use: As a dietary supplement, take 1 digestive enzymes capsule, 3 times daily, with each meal, or as directed by a health professional
- Pure Difference: What we leave out matters, too; Pure Encapsulations products are FREE FROM common allergens, artificial or unnecessary ingredients, and GMOs
$39.40
SALE
−$3.00
Carlyle Pancreatin Digestive Enzymes | 3000mg | 250 Caplets | Non-GMO, Gluten Free | High Potency Formula
- PANCREATIC ENZYMES: Features Pancreatin, Amylase, Protease, and Lipase, for multi-enzyme support
- ULTRA STRENGTH: Provides the equivalent of 3,000 mg of Pancreatin per serving in coated caplets
- ROOTED IN WELLNESS: Carlyle provides premium, honest supplements in your pursuit to healthy living
- CARLYLE MANUFACTURERS: Laboratory Tested, Trusted Ingredients, Superior Quality, 100% Guaranteed!
- NATURALLY FREE OF: Gluten, Wheat, Yeast, Lactose, Soy, Artificial Flavor, Preservatives & Non-GMO
$16.99
Micrazym AVVA Pharmа Pancreatic Enzymes - 10,000 USP Effective Pancreatic Enzyme Supplements - Digestive Enzymes for Digestion - 50 Fast-Acting Capsules with Amylase, Lipase and Protease
- ✅ ULTRA high-strength formula: 10,000 USP units of Micrazym digestive enzyme supplements containing lipase, protease, and amylase to help break down fats / lipids, proteins, and carbohydrates.
- ✅ UNIQUE: Micrazym is comprised of optimally sized (0.8–1.8mm) micropellets with an enteric coating. The enzymes are protected from from deactivation by the gastric acid, only released in the duodenum and small intestine where physiologically occur.
- ✅ HIGHEST STANDARDS: Full compliance with USP and European Pharmacopoeia on Acid Resistance, Dissolution and Stability.
- ✅ ULTRA EFFECTIVE: One capsule of Micrazym can replace up to 5-15 tablets. Convenient Intake and Cost Effective. Order Micrazym with confidence!
- ✅ PEACE OF MIND: manufactured exclusively in an FDA registered EU GMP certified facility to ISO 9001 and ISO 13485 standards so you are safeguarded by the highest standards.
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Ancestral Supplements Grass Fed Beef Pancreas Supplement, 500mg, Pancreatic Support with Proteolytic Digestive Enzymes for Digestion Support, Including Trypsin, Non GMO, 180 Capsules
- TIME-HONORED PANCREAS SUPPLEMENTS: Grounded in the traditional wisdom of ancient practices, this pancreas beef organ supplement is rich in pancreatic proteolytic enzymes, including lipase, protease, trypsin, and amylase to support pancreatic and digestive health.
- DIGESTIVE ENZYME BENEFITS: The pancreatic enzymes in these nutrient-dense organ supplements help break down fats (Lipase), proteins (Protease, Trypsin) and carbohydrates (Amylase) to provide digestive support.
- WHOLE FOOD NUTRITION SOURCE: Our pancreas supplements are a whole food that contains proteins, peptides, enzymes and cofactors exclusively expressed in pancreas that encourage nutrient absorption to nourish our entire being.
- NEW ZEALAND AND AUSTRALIA GRASS FED BEEF: Made in small batches in the USA without GMOs, fillers, or flow agents and third party verified for purity, our supplements are sourced from 100% grass fed cows, pasture-raised without hormones in green fields.
- DENSE NUTRITION FOR PANCREATIC AND DIGESTIVE SUPPORT: As the founders of the Beef Organ Movement, our mission is to make vital nutrition through the highest possible quality organ consumption accessible for all, putting back in what the modern world has left out.
$44.39
Digestive Enzymes - 800mg Blend of All 10 Most Essential Digestive and Pancreatic Enzymes (Amylase, Lipase, Bromelain, Lactase, Papain, Protease, Cellulase, Maltase, Invertase) by Double Wood
- CONTAINS ALL 10 MOST ESSENTIAL DIGESTIVE ENZYMES: No other digestive enzyme blend contains all 10 most essential digestive enzymes including Amylase, Lipase, Bromelain, Lactase, Papain, Protease, Cellulase, Maltase, Invertase, and Glucoamylase
- TOP 3 PANCREATIC ENZYMES INCLUDED: The Amylase pancreatic enzyme breaks down starches and carbohydrates into sugars. The Lipase enzyme breaks down fats and oils, into glycerol and fatty acids. Lastly, the Protease enzymes break down proteins into amino acids
- VITAZYME DIGESTIVE AID: Double Wood's trademarked digestive enzyme supplement aids digestion and supports overall digestive health. Delivering super enzymes to help with bloating relief
- BREAKDOWN PROTEIN, FATS, AND CARBOHYDRATES: Double Wood's Vitazyme blend contains the most essential digestive and pancreatic enzymes needed to break down fats, proteins, and carbohydrates
- WE BOTTLE WELLNESS: At Double Wood we provide pure, potent supplements that deliver exceptional value, all backed by careful sourcing and rigorous third-party testing
$18.95
SALE
−$7.54
Physician's CHOICE Digestive Enzymes - Multi Enzymes, Organic Prebiotics & Probiotics for Digestive Health & Gut Health - Meal Time Discomfort Relief & Bloating - Dual Action Approach - 60 CT
- Beat the Bloat & Say Goodbye to Meal Time Discomfort: 16 beneficial enzymes that digest proteins, carbs, fruits, veggies, beans, dairy, & fats to cover all diets. With SBO Probiotics & Prebiotics to aid digestion further - Your New Meal Time Hack! Same great product you love, with a new look. Packaging May Vary!
- Dual Action Relief: Our powerful digestive enzymes aid with breaking down food while the prebiotics & probiotics promote digestive function in the gut. They work synergistically to provide relief from mealtime discomfort.
- Probiotics that Survive the Gut: Formulated with 3 soil-based probiotic strains - specifically selected due to their ability to survive the harsh gut environment. Along with Organic Prebiotics that fuel the growth of healthy bacteria in the gut.
- Science Backed - Our Digestive Enzyme Probiotics are crafted based on scientific research. We have partnered with expert physicians to help review our products & research. We strive to educate & help you with informed decisions regarding your health.
- Safety Assured Standard of Quality: Our Digestive Enzymes are 3rd-party tested for purity and potency. Each bottle is manufactured w/ love & care in the USA with strict quality control - using imported & domestic ingredients. No Refrigeration Needed
$15.98
SALE
−$18.04
NOW Foods Supplements, Super Enzymes, Formulated with Bromelain, Ox Bile, Pancreatin and Papain,180 Capsules
- SUPPORTS HEALTHY DIGESTION*: NOW Super Enzymes is a comprehensive blend of enzymes that supports healthy digestion.* Take one capsule with a meal
- BREAKS DOWN FATS, CARBS, AND PROTEINS*/OPTIMIZES NUTRIENT AVAILABILITY*: Formulated with bromelain, ox bile, pancreatin and papain, Super Enzymes helps to optimize the breakdown of fats, carbohydrates and protein*
- CERTIFICATIONS/CLASSIFICATIONS: Soy Free, Made without Gluten, Keto Friendly
- GMP Quality Assured: NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods (for stability, potency, and product formulation)
- Packaged in the USA by a family owned and operated company since 1968
$25.95
Last update on 2025-05-03 / Affiliate links / Images from Amazon Product Advertising API