Painkiller for toothache can provide much-needed relief when dental discomfort strikes. In 2025, several effective options stand out for their ability to alleviate pain quickly and efficiently. Over-the-counter medications like ibuprofen and acetaminophen are popular choices, while topical treatments containing benzocaine offer localized relief. Natural remedies, such as clove oil and saltwater rinses, also remain favored for their soothing properties. For those seeking prescription options, stronger analgesics may be recommended by dental professionals. Understanding the best painkillers available can help individuals manage their toothache effectively and return to their daily activities with ease.
SALE
−$2.52
DenTek Instant Oral Pain Relief Maximum Strength Kit for Toothaches | 50 Count
- DenTek Instant Pain Relief, Advanced Kit gives instant and precise relief from oral pain and toothaches
- Ergonomic handle to reach any area of the mouth gives simple, no-fingers no-mess, relief
- Fresh Mint flavored Benzocaine relieves tooth pain, sore gums and mouth sores
- Maximum strength pain reliever
- 50 disposable applicators easily slide into the handle for a sanitary way to relieve tooth pain
$7.43
SALE
−$0.41
Orajel 3X for Toothache & Gum Pain: Maximum Gel Tube 0.42oz - From #1 Oral Pain Relief Brand - Orajel for Instant Pain Relief
- INSTANT PAIN RELIEF: Instant pain relief with Orajel’s maximum strength formula to help relieve pain of the tooth and gums with 20% benzocaine
- KILLS HARMFUL BACTERIA: Unique formula is designed to help kill harmful bacteria in the mouth, and can help to prevent infections
- COOLING RELIEF: To help relieve gum irritation, Orajel toothache gel contains cooling relief
- EASY OPEN: Now with a Ready-Open Tube Tip for easy access to the relief you need. A convenient remedy for use at home or on the go
- From the Oral Pain Reliever Brand for Adults
$6.98
SALE
−$2.51
Orajel 4X for Toothache & Gum Pain: Severe Cream Tube 0.33oz- From Oral Pain Relief Brand
- INSTANT PAIN RELIEF: Instant pain relief with Orajel’s unique 4X clinical strength formula to help relieve pain of the tooth and gums
- 4X ACTIVE INGREDIENTS: With 4 active ingredients, Orajel Cream provides fast acting and maximum strength relief when you need it most
- KILLS HARMFUL BACTERIA: Unique formula is designed to help kill harmful bacteria in the mouth, and can help to prevent infections
- COOLING RELIEF: To help relieve gum irritation, Orajel 4X cream contains cooling relief
- EASY OPEN: Now with a Ready-Open Tube Tip for easy access to the relief you need. A convenient remedy for use at home or on the go.
$7.48
Red Cross Complete Medication Kit for Tooth Pain, 0.125 oz
- WORKS INSTANTLY
- LONG-LASTING Pain relief
- FORMULATED: Eugenol 85%, an ingredient used by dentists
- KIT INCLUDES: Medication, tweezers, and cotton pellets; Easy, controlled, and accurate application
- USED BY DENTISTS
$9.37
The Goodbye Company Toothache Pain Relief - Infused with Clove Essential Oil & Peppermint Oil Organic - 100% Natural Tooth Ache Pain Reliever, BPA Free & Made in USA (15ml)
- EXPERIENCE NATURAL PAIN RELIEF: Discover the potent power of our toothache oil, expertly blended with clove bud oil, peppermint oil, and Omega 3 & 9. This natural remedy provides swift and effective relief from dental pain, ensuring you can get back to your day with a smile.
- PURE INGREDIENTS FOR YOUR HEALTH: Our formula is 100% natural and BPA-free, designed with your well-being in mind. We prioritize using only the highest quality ingredients, so you can trust that our oil of cloves for toothache relief is safe and beneficial for you and your family. Try this tooth sensitivity pain relief now!
- SIMPLE & EFFECTIVE USAGE: For precise pain relief, apply a few drops directly to the painful tooth and surrounding gums with a swab. Alternatively, for broader pain and infection control, swish a dropper full in your mouth. Our tooth oil not only alleviates pain but also promotes stronger, healthier teeth, giving you a reason to smile every day.
- THE GOODBYE COMPANY'S MISSION: As a family-owned business, we are passionate about helping people regain hope by effectively addressing common health issues. Our mission is to provide solutions that genuinely improve your quality of life, keeping your family's health at the forefront of everything we do.
- HASSLE-FREE PURCHASE: We are committed to the excellence of our clove oil for tooth aches, and delivering the best customer service possible. Should you encounter any issues with your order or product, please contact us immediately. Your satisfaction is our top priority, and we are here to ensure you have a hassle-free experience.
$17.95
Orajel 2X Medicated Toothache & Mouth Sores Liquid, 0.45 fl oz
- 20% Benzocaine to relieve oral pain
- Menthol to soothe gums
- Fast-acting liquid for instant pain relief
- #1 Oral Pain Reliever Brand for Toothache
- 2 times as many active ingredients as single medicated oral pain products
$11.29
Anbesol Maximum Strength Oral Anesthetic Liquid - 0.41 fl oz (packaging may vary)
- Instant Oral Pain Relief: Anbesol Maximum Strength Liquid for mouth pain, including toothache pain, canker sores, sore gums, mouth sores, denture pain, braces, retainer and aligner pain, and minor dental procedures
- OW to WOW! Instantly: Formulated with the active ingredient Benzocaine, an oral pain reliever, and numbs instantly to temporarily relieve toothaches, gum pain, canker sores and aligner pain.
- Liquid Formula: Anbesol Liquid Formula goes on clear and is undetectable, stays where you apply it, and provides fast and effective numbing of oral pain
- ADA Accepted: Accepted by the American Dental Association and has shown efficacy to help temporarily relieve discomfort of mouth sores
- Convenient: Take the tiny Anbesol gel tube with you for oral pain relief on-the-go up to 4x daily. For adults and children 2 years and older with adult supervision. Use as directed
$10.84
SALE
−$1.22
Boiron Hekla Lava 6C Homeopathic Medicine for Toothache - 80 Pellets
- PURE RELIEF: Hekla Lava is a homeopathic medicine that relieves toothache.*
- A BETTER WAY TO FEEL BETTER: This medicine has no known interactions with other medications, herbs, or supplements; no contraindications; and does not contain artificial colors, flavors, sweeteners, or preservatives
- EASY TO TAKE: Pellets melt under the tongue, no food or water needed and great for on the go
- A TRUSTED BRAND: With more than 90 years of expertise, Boiron medicines are made to meet the highest standards of cGMP and HPUS for purity and quality
- HSA & FSA eligible: Boiron homeopathic medicines are HSA & FSA eligible.
$7.27
BestMade Natural Products Toothache & Nerve Support in Jaw | Helps Ease Tooth Sensitivity and Oral Discomfort Following Dental Work | Bio23 | Pellets
- Natural Relief for Sensitive Teeth: Our homeopathic formula offers gentle, natural support for teeth and nerve sensitivity. It works towards mitigating daily discomforts in your mouth without relying on synthetic chemicals present in over-the-counter remedies.
- Post-Dental Comfort: This remedy is designed to help ease the discomfort often experienced after dental procedures. It's a natural choice that puts your well-being first and can be used as part of your post-dental care routine.
- Responsibly Made: Bestmade Natural Products strives to provide high-quality, all-natural solutions. Our homeopathic remedies are free from harmful additives, prioritizing your health while providing effective relief.
- Trusted Brand Commitment: Bestmade Natural Products is dedicated to providing safe, effective solutions as a trusted brand in the homeopathic industry. Our customer service team is always ready to assist with your questions and concerns.
- Holistic Support: Adding our remedy to your daily routine can contribute to a more holistic, healthy lifestyle. Its natural formulation fits seamlessly into your existing wellness regimen, promoting a more comfortable oral health experience.
$27.99
SALE
−$1.25
Anbesol Maximum Strength Oral Pain Relief Gel, Instant Pain Relief For Toothache Pain, Canker Sores, Sore Gums, Mouth Sores, Denture Pain, and Aligner Pain, ADA Accepted, 0.33 oz (packaging may vary)
- INSTANT PAIN RELIEF: Instant oral pain relief for mouth and gum irritation due to toothaches, canker sores, sore gums, denture pain, and minor dental procedures. Use with dentures to relieve discomfort.
- MAXIMUM STRENGTH: Instant relief that takes you from ouch to ahhh! So, oral pain doesn’t hold you back. Formulated with 20% Benzocaine to offer maximum strength pain relief and instantly soothe mouth pain and dental irritation
- EASY TO USE: Cut the Tube Tip for easy access to the oral pain relief you need; Adults and children 2 years and over. Not for use in children under 2 years of age.
- ACTIVE INGREDIENT: Benzocaine 20% Oral anesthetic for pain relief.
$6.74
Last update on 2025-05-03 / Affiliate links / Images from Amazon Product Advertising API