Pain relief cream is an essential solution for those seeking quick and effective relief from discomfort. In 2025, the market offers a variety of top-rated options that cater to different needs, from muscle soreness to joint pain. These creams are formulated with powerful ingredients that provide soothing effects and promote healing, making them a must-have in any first-aid kit. Whether you prefer natural ingredients or advanced formulations, there’s a pain relief cream that can help alleviate your symptoms and improve your quality of life.
SALE
−$4.27
Boiron Arnicare Gel for Soothing Relief of Joint Pain, Muscle Pain, Muscle Soreness, and Swelling from Bruises or Injury - Non-greasy and Fragrance-Free - 2.6 oz
- ARNICA FOR PAIN: This homeopathic medicine helps temporarily relieve muscle pain & stiffness due to minor injuries, overexertion & falls. Also great for pain, swelling, & discoloration from bruises.
- TOPICAL PAIN RELIEF: Our non-greasy, water-based formula absorbs quickly & is unscented & paraben-free. This cooling gel is great for relief following an injury, intense workout, or general overexertion.
- PLANT-BASED ACTIVE INGREDIENT: The Arnica montana plant is a natural pain reliever. This popular homeopathic medicine temporarily relieves muscle pain & stiffness without unwanted drowsiness.Fluoride-Free
- HOMEOPATHIC MEDICINE uses highly diluted biological, botanical, or mineral substances to relieve symptoms. Our tablets, pellets, & topical treatments work with your body without the risk of contraindications, or known drug interactions.
- THE BOIRON PROMISE: We believe there’s more than one way to feel better. Since 1932, we have been committed to providing quality medicines. As a world leader in homeopathy, our passion is your health. Our promise is your satisfaction.
$8.32
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−$4.01
Aspercreme Lidocaine Pain Relief Cream Soothes Aggravated Nerves, Numbing Topical Analgesic with Max-Strength 4% Lidocaine & Moisturizing Aloe, 4.3 Oz.
- Contains one (1) 4.3-oz. tube of Aspercreme Pain Relief Cream With Max-Strength Lidocaine & Moisturizing Aloe
- Fast-Acting Relief: Experience rapid and lasting pain relief with max-strength 4% lidocaine topical numbing cream, designed to target nerves and numb away pain
- Non-greasy Formula: Fragrance-free Aspercreme moisturizes and relieves without greasy residue or strong odor
- Maximum-Strength Lidocaine: OTC Aspercreme offers the maximum-strength lidocaine pain relief available without a prescription and is FSA/HSA eligible
- Travel-Size: Take your pain relief solution on the go in a compact and portable tube
$7.48
Penetrex Joint & Muscle Therapy - Soothing Comfort for Back, Neck, Hands, Feet - Premium Whole Body Rub with Arnica, Vitamin B6 MSM & Boswellia - Non-Greasy 2oz Cream
- Effective for Joints and Muscles: Penetrex is the whole-body therapy cream you’ve been waiting for; trusted by over 2 million sufferers; offers a different kind of comfort
- The Penetrex Difference: Our proprietary blend of natural ingredients leverages the power of arnica, vitamin B6 and MSM to penetrate deeply for joint and muscle discomfort at the source
- Premium Experience: Penetrex is a non-greasy, non-sticky, non-staining, paraben-free, cruelty-free and vegan soothing cream without the burn, freeze or strong odor of other products
- See Why So Many People Trust Penetrex: Penetrex allows you to get back to doing the things you love
- Directions: Apply to back, neck, knee, hand, foot, and more; Penetrex can be used on its own or with other therapies such as heating pads, ice packs, massagers and supplements; apply 3-4 times per day for 7-10 days, then apply as needed
$16.98
Bengay Ultra Strength Topical Pain Relief Cream, Non-Greasy Topical Analgesic for Minor Arthritis, Muscle, Joint and Back Pain, Camphor, Menthol and Methyl Salicylate, 4 OZ
- 4-ounce tube of non-greasy Bengay Ultra Strength Topical Pain Relief Cream to ease backaches, minor arthritis, muscle, and joint pain
- Topical analgesic contains three pain-relieving ingredients—camphor, menthol, and methyl salicylate, for ultra-strong relief in a non-greasy cream.
- Pain relief cream penetrates deeply for back and arthritis pain relief and soothing of other minor aches, sprains and bruises
- Bengay is a physician-recommended OTC topical analgesic. Contains more pain-relieving ingredients than any other Bengay product
- Topical pain relief analgesic comes in a convenient tube for portable & on-the-go relief from aches, minor arthritis, joint, and back pain
$7.59
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−$8.22
Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief with Diclofenac - NEW Easy Open Cap - 100 g x 2
- Two 3.5 oz/100 g tubes of Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief- Easy flip cap that can be opened with your palm, fingers, or even with just one hand; packaging may vary
- Number 1 Doctor Recommended topical pain relief brand
- Clinically Proven to relieve arthritis pain, improve mobility and reduce stiffness, aches and pains to provide prescription strength arthritis pain relief
- An Alternative to Pills, Voltaren is a nonsteroidal anti-inflammatory gel that combines the benefits of an arthritis cream and gel for arthritis pain management*
- Voltaren Arthritis Pain Gel Penetrates Deep to attack arthritis pain directly at the source of inflammation, treating arthritis pain
$24.27
Advil Targeted Relief Pain Relieving Cream, Up to 8 Hours of Powerful Relief of Minor Arthritis Pain, Joint Pain, Lower Back Pain and Muscle Pain - 2.3 oz
- One 2.3 oz Tube of Advil Targeted Relief Pain Relieving Cream - The only topical pain reliever with 4 powerful pain-fighting ingredients (1)
- Provides a warming & cooling sensation on contact and lasts up to 8 hours (1)
- Designed to quickly tackle pain four ways: targets, penetrates, blocks, and relieves
- Fast and powerful relief for minor arthritis pain, muscle, joint and back pain - the perfect addition to your college dorm room essentials
- Doesn't leave your skin feeling dry or greasy and easily glides onto skin, ensuring comfort with every use
$10.98
Biofreeze Pain Relief Cream, Knee & Lower Back Pain Relief, Sore Muscle Relief, Neck Pain Relief, Shoulder Pain Relief, Muscle Recovery, FSA Eligible, 3 OZ Biofreeze Menthol Cream
- PAIN RELIEVER: Enjoy cooling pain relief with Biofreeze, the #1 clinician recommended menthol topical pain relief brand*; Helps relieve minor aches & pains of muscles & joints associated with simple backache, arthritis, strains, bruises & sprains
- LOWER BACK PAIN RELIEF: Ideal for both athletes & everyday ache sufferers, our non-greasy pain relief cream provides targeted menthol pain relief for simple backache; Also helps relieve soreness during muscle recovery
- NECK PAIN RELIEF: Relieve neck pain with Biofreeze; Trusted by chiropractors, podiatrists, physical therapists, massage therapists, retail pharmacists, & athletic trainers
- FAST-ACTING BIOFREEZE CREAM WITH NATURAL MOISTURIZERS: When you're in pain, you need a fast-acting formula that works - Biofreeze delivers cooling, targeted relief and won't wear off quickly, so you can get back to your best
- SHOULDER PAIN RELIEF: Whether you have pain from a bruise, arthritis, or an intense workout, our moisturizing pain relief cream powered by menthol stimulates cold receptors that create a cooling sensation, helping to relieve pain
$11.98
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−$2.40
Neosporin + Maximum-Strength Pain Relief Dual Action Cream, First Aid Topical Antibiotic & Analgesic Cream for Wound Care of Minor Cuts, Scrapes & Burns, Polymyxin B & Pramoxine HCl, 1 oz
- 1-ounce tube of Neosporin + Pain Relief Dual Action Antibiotic Cream for first aid wound care of minor cuts, scrapes, and burns
- Topical antibiotic cream provides infection protection of minor wounds and helps to soothe and reduce pain with a maximum-strength, no-sting formula
- Contains both neomycin sulfate and polymyxin B sulfate antibiotics to help prevent wound infection of minor cuts, scrapes and burns and pramoxine hydrochloride as an external analgesic for maximum-strength pain relief
- The dual-action cream from the #1 doctor recommended brand not only helps fight infection for 24 hours, but also soothes & reduces pain, making it a great addition to your first-aid kit and wound care supplies
- For best results, clean the affected area, apply a small amount of the topical antibiotic and pain relief cream 1 to 3 times daily, and cover with a sterile bandage
$9.99
Last update on 2025-05-03 / Affiliate links / Images from Amazon Product Advertising API