Pain cream is an essential solution for those seeking relief from discomfort and soreness. In 2025, the market offers a variety of effective options that cater to different needs, from muscle strains to chronic pain. These creams are formulated with powerful ingredients that provide targeted relief, making them a popular choice among athletes and individuals with active lifestyles. Whether you prefer natural ingredients or advanced formulations, there’s a pain cream that can help alleviate your symptoms and enhance your quality of life.
SALE
−$4.27
Boiron Arnicare Gel for Soothing Relief of Joint Pain, Muscle Pain, Muscle Soreness, and Swelling from Bruises or Injury - Non-greasy and Fragrance-Free - 2.6 oz
- ARNICA FOR PAIN: This homeopathic medicine helps temporarily relieve muscle pain & stiffness due to minor injuries, overexertion & falls. Also great for pain, swelling, & discoloration from bruises.
- TOPICAL PAIN RELIEF: Our non-greasy, water-based formula absorbs quickly & is unscented & paraben-free. This cooling gel is great for relief following an injury, intense workout, or general overexertion.
- PLANT-BASED ACTIVE INGREDIENT: The Arnica montana plant is a natural pain reliever. This popular homeopathic medicine temporarily relieves muscle pain & stiffness without unwanted drowsiness.Fluoride-Free
- HOMEOPATHIC MEDICINE uses highly diluted biological, botanical, or mineral substances to relieve symptoms. Our tablets, pellets, & topical treatments work with your body without the risk of contraindications, or known drug interactions.
- THE BOIRON PROMISE: We believe there’s more than one way to feel better. Since 1932, we have been committed to providing quality medicines. As a world leader in homeopathy, our passion is your health. Our promise is your satisfaction.
$8.32
SALE
−$8.22
Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief with Diclofenac - NEW Easy Open Cap - 100 g x 2
- Two 3.5 oz/100 g tubes of Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief- Easy flip cap that can be opened with your palm, fingers, or even with just one hand; packaging may vary
- Number 1 Doctor Recommended topical pain relief brand
- Clinically Proven to relieve arthritis pain, improve mobility and reduce stiffness, aches and pains to provide prescription strength arthritis pain relief
- An Alternative to Pills, Voltaren is a nonsteroidal anti-inflammatory gel that combines the benefits of an arthritis cream and gel for arthritis pain management*
- Voltaren Arthritis Pain Gel Penetrates Deep to attack arthritis pain directly at the source of inflammation, treating arthritis pain
$24.27
Penetrex Joint & Muscle Therapy - Soothing Comfort for Back, Neck, Hands, Feet - Premium Whole Body Rub with Arnica, Vitamin B6 MSM & Boswellia - Non-Greasy 2oz Cream
- Effective for Joints and Muscles: Penetrex is the whole-body therapy cream you’ve been waiting for; trusted by over 2 million sufferers; offers a different kind of comfort
- The Penetrex Difference: Our proprietary blend of natural ingredients leverages the power of arnica, vitamin B6 and MSM to penetrate deeply for joint and muscle discomfort at the source
- Premium Experience: Penetrex is a non-greasy, non-sticky, non-staining, paraben-free, cruelty-free and vegan soothing cream without the burn, freeze or strong odor of other products
- See Why So Many People Trust Penetrex: Penetrex allows you to get back to doing the things you love
- Directions: Apply to back, neck, knee, hand, foot, and more; Penetrex can be used on its own or with other therapies such as heating pads, ice packs, massagers and supplements; apply 3-4 times per day for 7-10 days, then apply as needed
$16.98
SALE
−$4.01
Aspercreme Lidocaine Pain Relief Cream Soothes Aggravated Nerves, Numbing Topical Analgesic with Max-Strength 4% Lidocaine & Moisturizing Aloe, 4.3 Oz.
- Contains one (1) 4.3-oz. tube of Aspercreme Pain Relief Cream With Max-Strength Lidocaine & Moisturizing Aloe
- Fast-Acting Relief: Experience rapid and lasting pain relief with max-strength 4% lidocaine topical numbing cream, designed to target nerves and numb away pain
- Non-greasy Formula: Fragrance-free Aspercreme moisturizes and relieves without greasy residue or strong odor
- Maximum-Strength Lidocaine: OTC Aspercreme offers the maximum-strength lidocaine pain relief available without a prescription and is FSA/HSA eligible
- Travel-Size: Take your pain relief solution on the go in a compact and portable tube
$7.48
Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief with Diclofenac - NEW Easy Open Cap - 150 g
- One 5.3 oz/150 g tube of Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief- Easy flip cap that can be opened with your palm, fingers, or even with just one hand; packaging may vary
- Number 1 Doctor Recommended topical pain relief brand
- Clinically Proven to relieve arthritis pain, improve mobility and reduce stiffness, aches and pains to provide prescription strength arthritis pain relief
- An Alternative to Pills, Voltaren is a nonsteroidal anti-inflammatory gel that combines the benefits of an arthritis cream and gel for arthritis pain management
- Voltaren Arthritis Pain Gel Penetrates Deep to attack arthritis pain directly at the source of inflammation, treating arthritis pain
$23.93
Biofreeze Pain Relief Cream, Knee & Lower Back Pain Relief, Sore Muscle Relief, Neck Pain Relief, Shoulder Pain Relief, Muscle Recovery, FSA Eligible, 3 OZ Biofreeze Menthol Cream
- PAIN RELIEVER: Enjoy cooling pain relief with Biofreeze, the #1 clinician recommended menthol topical pain relief brand*; Helps relieve minor aches & pains of muscles & joints associated with simple backache, arthritis, strains, bruises & sprains
- LOWER BACK PAIN RELIEF: Ideal for both athletes & everyday ache sufferers, our non-greasy pain relief cream provides targeted menthol pain relief for simple backache; Also helps relieve soreness during muscle recovery
- NECK PAIN RELIEF: Relieve neck pain with Biofreeze; Trusted by chiropractors, podiatrists, physical therapists, massage therapists, retail pharmacists, & athletic trainers
- FAST-ACTING BIOFREEZE CREAM WITH NATURAL MOISTURIZERS: When you're in pain, you need a fast-acting formula that works - Biofreeze delivers cooling, targeted relief and won't wear off quickly, so you can get back to your best
- SHOULDER PAIN RELIEF: Whether you have pain from a bruise, arthritis, or an intense workout, our moisturizing pain relief cream powered by menthol stimulates cold receptors that create a cooling sensation, helping to relieve pain
$11.98
Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief with Diclofenac, No Prescription Needed - 1.7 oz/50 g Tube
- One 1.7 oz/50 g tube of Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief
- Number 1 Doctor Recommended topical pain relief brand
- Clinically Proven to relieve arthritis pain, improve mobility and reduce stiffness, aches and pains to provide prescription strength arthritis pain relief
- An Alternative to Pills, Voltaren is a nonsteroidal anti-inflammatory gel that combines the benefits of an arthritis cream and gel for arthritis pain management
- Diclofenac Sodium Topical Gel Penetrates Deep to attack arthritis pain directly at the source of inflammation, treating arthritis pain
$10.98
Sombra Warm Pain Relief Gel, Warm Relief for Arthritis and Chronic Pain Pre-Workout Muscle Rub Vegan Formula Free of Artificial Fragrances, Dyes, NSAIDs, Wax, Petroleum, Alcohol - 4oz Jar
- TRIED AND TRUE PAIN RELIEF FOR 5+ DECADES | For Over 50 Years, Our Family-Owned Business Has Provided You With High-Quality Products You Can Trust | From Pre-Workout Tension Relief to Daily Arthritis Care, Our Original Warm Therapy Gel Provides Relaxing, Available in Multiple Sizes & Dispense Options, You’ll be Ready to Relieve Pain from Anywhere
- IDEAL FOR YOUR AT-HOME FIRST AID KIT | Ease Muscle Pain, Joint Sensitivity, & Pre-Workout Muscle Tension | Sombra’s Original Warm Therapy Gel Also Offers Quick Relief for Pain Due to Arthritis, Fibromyalgia, or Lupus Flares | Keep Our Roll-On Tube in Your Mobile First Aid Kit, and an 8 oz Jar in Your Kit at Home, For Complete Peace of Mind
- PREMIUM-QUALITY, PLANT-DERIVED INGREDIENTS | Warming Camphor & Cooling Menthol Combine With Aloe Vera, Green Tea, Witch Hazel, Flowers, Herbs, & Other Plant Extracts to Provide Comfort & Relief | No Artificial Colors or Fragrances | Free From Dyes, Gluten, Waxes, Petroleum, Alcohol, NSAIDs, & Animal Products | Refreshing Lemon Scent
- TRUSTED BY DOCTORS & CAREGIVERS NATIONWIDE | Get Clinical-Quality Relief, Over The Counter | Sold in Doctor’s Offices for Over 35 Years, Sombra Products Are Now Available to Individual Shoppers Through Popular Retailers | Our OTC Products Still Contain Powerful, 3% Camphor & Menthol For Exceptional Relief Without a Doctor’s Visit
- GREAT FOR ATHLETES, HOBBYISTS, & SENIORS | Calm Muscle Tension Before Running, Weightlifting, Dancing, & Hiking | Soothe Cramps From Gaming Sessions, Crafting, Pickleball, Gardening, & Other Hobbies | Non-Staining, Vegan Formula is Easy to Apply & Acts Fast, So You Can Get Back to The Things That Matter Most to You
$13.49
Activene Pain Relief Cream - Anti Inflammatory formulation with Powerful Arnica, Menthol & MSM for Joints, Tendons & Muscles. Chosen by Sufferers of Arthritis, Knee, Shoulder, Neck, Back & Other Pains
- THOUSANDS OF HAPPY CUSTOMERS – from professional physiotherapists to arthritis sufferers. We have a track record of real people getting real results with Activene!
- MADE IN THE USA with the highest quality standards and registered with the FDA. Cruelty free! Ingredients include Arnica Montana, Menthol (3.7%), Aloe Vera, Tea Tree Oil, Ilex Leaf Extract, MSM, Vitamin E and B6.
- NON-GREASY, NON-STAINING, FAST ABSORBING Arnica gel cream with a refreshing mint scent. Within minutes, the cream is absorbed and the scent is vanished. Get back to your normal life!
- TRUSTED PAIN RELIEF: Activene Arnica Cream is chosen by sufferers of Arthritis, Tendonitis, Tennis Elbow, Shoulder Pain, Bursitis, Sciatica, Shin Splints, Neuropathy, Fibromyalgia, Plantar Fasciitis, Back, Neck, Knee pain and other muscle and joint pains.
- MONEY BACK GUARANTEE: We stand behind Activene 100% and are sure you are going to love it. That's why we go far beyond Amazon's 30-day guarantee. If you are not happy with Activene within 365 days, we offer a full refund. No questions asked. Order now, worry free!
$24.97
HealthWise Maximum Strength Lidocaine Cream | Numbs Away Pain | Long-Lasting Relief | Non-Greasy | 1.75 Oz
- MAXIMUM STRENGTH RELIEF — Provides temporary relief of minor aches and pains of muscles and joints associated with arthritis, simple backaches, strains, sprains and bruises; apply directly to the skin
- FAST-ACTING LIDOCAINE — Containing 4% lidocaine, this cream works by desensitizing the nerves, effectively numbing the pain where the cream is applied with no irritation and no burning
- NON-GREASY FORMULA — Non-greasy formula glides on smooth; safely apply every 6-8 hours, up to 3x daily
- SUPPORT AND INSTRUCTION — Follow the detailed use instructions, as well as the warnings and cautions, before use; use only as directed, instructions are easy to follow and use
- Compare to Aspercreme with Lidocaine active ingredients
$2.99
Last update on 2025-05-02 / Affiliate links / Images from Amazon Product Advertising API