OTC flea treatment for dogs is essential for maintaining your pet's health and comfort. In 2025, several products stand out for their effectiveness and safety. These treatments not only eliminate existing fleas but also provide long-lasting protection against future infestations. From topical solutions to oral medications, the best options cater to various needs and preferences, ensuring that every dog can find a suitable remedy. With the right OTC flea treatment, you can keep your furry friend happy and flea-free.
TevraPet Activate II Flea and Tick Prevention for Dogs | 4 Count | Extra Large Dogs 55+ lbs | Topical Drops | 4 Months Flea Treatment
- COMPARE TO K9 ADVANTIX II: Activate II uses Imidacloprid, Permethrin, and Pyriproxyfen - the same safe, fast acting active ingredients used in Advantix II for Dogs. Includes 4 monthly doses
- ACTIVELY PROTECTS YOUR DOG: Activate II is approved by veterinarians to repel and kill fleas and ticks on contact - before your dog is exposed to bites and potential flea borne illnesses
- STOP INFESTATIONS FAST: Our topical drops prevent infestations by breaking the flea life cycle - our insect growth regulator (IGR) starts killing flea eggs and larvae within 12 hours of application
- EASY TO APPLY: Simply apply to the base of your dog's neck, and the waterproof solution will travel across the skin - providing continuous protection for 30 days per application
- MADE IN AMERICA - RESULTS GUARANTEED: TevraPet Activate II is made to the quality standard we demand for our own pets. We're proud to help you protect your dog with confidence
$26.97
SALE
−$5.01
FRONTLINE Plus Flea and Tick Treatment for Small Dogs Upto 5 to 22 lbs. 3 Treatments
- Keep your dog protected from fleas & ticks all month long with FRONTLINE Plus for Dogs a fast-acting, waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease
- Break the flea life cycle with FRONTLINE Plus, specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control
- Trusted by pet owners for over 20 years, FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply with one monthly dose providing protection from fleas & ticks for a full 30 days
- FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over, so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products
- Treat all dogs or cats in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations
$39.98
PetArmor CAPACTION (nitenpyram) Oral Flea Treatment for Dogs, Fast Acting Tablets Start Killing Fleas in 30 Minutes, Dogs Over 25 lbs, 6 Doses (Pack of 1) (Packaging May Vary)
- FAST-ACTING: One oral flea tablet starts killing fleas within 30 minutes of administration.
- SAFE TO USE: This oral flea medication is safe for puppies, dogs, cats, and kittens from 25lbs. and over, when used as directed.
- TREAT RE-INFESTATIONS FAST: If your pet gets re-invested with fleas simply apply another dose as often as once a day. CapAction Flea Pills are even safe for use on pregnant or breeding dogs.
- EASY TO USE: Without the mess and rubbing off of a flea and tick topical treatment and without the need of a veterinarian prescription this dog flea tablet is administered orally to kill adult fleas fast.
- KILL FLEAS EFFICIENTLY: CapAction flea treatment has 6 doses and kills adult fleas that may cause allergy dermatitis.
$27.99
SALE
−$5.01
FRONTLINE Plus Flea and Tick Treatment for Large Dogs Up to 45 to 88 lbs. 3 Treatments
- Keep your dog protected from fleas & ticks all month long with FRONTLINE Plus for Dogs a fast-acting, waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease
- Break the flea life cycle with FRONTLINE Plus, specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control
- Trusted by pet owners for over 20 years, FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply with one monthly dose providing protection from fleas & ticks for a full 30 days
- FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over, so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products
- Treat all dogs or cats in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations
$39.98
Amazon Basics Flea and Tick Topical Treatment for Small Dogs (5-22 pounds), 3 Count (Previously Solimo)
- Same product, new look - This product is identical in manufacturing and formulation as the Solimo brand
- One 3 dose pack of Amazon Basics Flea and Tick Treatment for Dogs, Small (5-22 lbs), 3 Count (Previously Solimo)
- Amazon Basics Flea & Tick starts eliminating fleas and ticks within 24 hours of treatment
- Active ingredients Fipronil and (s)-methoprene prevent flea infestations by killing flea eggs, flea larvae, mosquitos, biting flies and chewing lice
- One application provides up to 30 days of protection
$19.25
SALE
−$4.06
PetArmor Plus Flea and Tick Prevention for Dogs, Dog Flea and Tick Treatment, 3 Doses, Waterproof Topical, Fast Acting, Large Dogs (45-88 lbs)
- EFFECTIVE, WATERPROOF FLEA TREATMENT FOR DOGS: PetArmor Plus is a waterproof, flea & tick topical prevention for dogs that kills fleas, flea eggs, flea larvae, ticks, and chewing lice for up to 30 days after application.
- TRUSTED, VET QUALITY* FORMULA: Containing fipronil and (S)-methoprene, the same active ingredients as FRONTLINE Plus for Dogs. PetArmor Plus for Dogs has a powerful formula that starts to kill fleas within 24 hours.
- BREAK THE FLEA CYCLE: Unlike other flea and tick treatments that may temporarily suppress flea activity, PETARMOR Plus Dog Flea Treatment works by effectively breaking the flea life cycle! Kill flea eggs and larvae to prevent re-infestation.
- FAST ACTNG LONG-LASTING FLEA AND TICK PROTECTION: One application of PetArmor Plus lasts up to 30 days nose to tail. A 6-dose package lasts up to six months.
- EASY-TO-USE, LONG-LASTING: PetArmor Plus flea and tick treatment comes with three (3) waterproof topical applications that provides your pet flea protection and control for three (3) months.
$24.93
Seresto Large Dog Vet-Recommended Flea & Tick Treatment & Prevention Collar for Dogs Over 18 lbs. | 8 Months Protection
- Vet-recommended, premium flea & tick protection for dogs & puppies without the price tag
- Long-lasting flea and tick collar kills & repels fleas for 8 continuous months
- Seresto is the #1 veterinarian recommended flea & tick collar*
- Starts working within 24 hours to kill & repel fleas by contact so pests don’t have to bite your dog to die
- Hassle-free, non-greasy, easy-to-use flea & tick protection
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SALE
−$2.00
Oral Flea and Tick Support for Dogs and Cats, Natural Dog Flea and Tick Defense, Cat Flea Drops Supplements with Vitamin for Pets - All Breeds and Ages - Bacon
- Natural Oral Flea & Tick Support for Dogs & Cats: Looking for a natural way to help protect your pets from fleas & ticks? Carmelie’s oral flea & tick drops provide an easy, plant-based solution for dogs and cats. Formulated with natural extracts, these daily drops help discourage fleas, ticks, eggs, larvae, and mosquitoes while supporting your pet’s skin health and overall wellness—so they can enjoy a more comfortable life.
- Bacon-Flavor: Our bacon-flavored flea & tick support drops offer a simple, enjoyable solution that pets love. These daily oral supplements provide an easy way to help maintain your pet's natural defenses against fleas and ticks, offering worry-free care every day.
- Multivitamin Blend - Wellness Support: Our unique formula combines beneficial plant extracts including pumpkin seed, Oregon grape root, and other natural ingredients to help maintain your pet's comfort. Enhanced with a multivitamin complex featuring vitamins B1, B6, B12, and E, plus apple cider vinegar, this blend supports healthy digestion, energy levels, skin and coat condition, and overall wellbeing for your companion animal.
- Suitable for Pets of All Ages, Breeds, and Sizes: Our dog and cats liquid flea and tick drops are suitable for pets of all ages, breeds, and sizes. You can administer them directly into food, water, or your pet’s mouth. For optimal results, use 1-2 times daily based on your pet's weight: Up to 10 lbs: ½ dropper (0.5 ml), 10-35 lbs: 1¼ droppers (1.25 ml), 35-75+ lbs: 2½ droppers (2.5 ml).
- Customer Support: If you have any questions about our liquid flea and tick support, feel free to reach out to us—we’re here to help!
$16.99
Capstar(nitenpyram) for Dogs Fast-Acting Oral Flea Treatment for Dogs 2-25 lbs, Vet-Recommended Medication Tablets Start Killing in 30 Minutes, 6 Doses
- Fast-Acting Flea Treatment: CAPSTAR (nitenpyram) starts killing adult fleas in just 30 minutes
- Tackle Flea Infestations Fast: With one dose of CAPSTAR, you can watch the dead fleas fall off your pet
- Treat Reinfestations Fast: If your pet gets reinfested with fleas, simply give another dose as often as once a day
- No Prescription Needed: Fast, effective flea treatment for dogs that's available over the counter
- Intended Use: CAPSTAR Oral Flea Treatment for Small Dogs (57 mg) is safe for dogs and puppies 4 weeks and older that weigh 2-25 pounds
$39.98
K9 Advantix II XL Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs Over 55 lbs. | 2-Mo Supply
- K9 Advantix II Extra Large Dog 30-day treatment & prevention protects dogs over 55 lbs. from fleas, ticks, mosquitoes, biting flies and lice
- Kills fleas within 12 hours of application
- Vet-recommended formula kills & repels on contact so fleas don’t have to bite your dog to die
- Easy-to-apply topical treatment is fragrance-free and waterproof after 24 hours
- No prescription needed
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Last update on 2025-05-03 / Affiliate links / Images from Amazon Product Advertising API