OTC flea treatment for cats is essential for maintaining your feline's health and comfort. In 2025, several products stand out for their effectiveness and safety. These treatments not only eliminate existing fleas but also provide long-lasting protection against future infestations. From topical solutions to oral medications, the best options cater to various needs and preferences, ensuring that every cat can find a suitable remedy. When choosing an OTC flea treatment, it's crucial to consider factors such as age, weight, and any pre-existing health conditions.
SALE
−$5.02
FRONTLINE Plus Flea and Tick Treatment for Cats Over 1.5 lbs. 3 Treatments
- FRONTLINE Plus for Cats provides waterproof, fast-acting, long-lasting flea and tick protection that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease
- Break the flea life cycle with FRONTLINE Plus for Cats, specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea & tick control
- Trusted by pet owners for over 20 years, FRONTLINE Plus for Cats can be used on kittens as young as eight weeks old, weighing 1.5 pounds or more; One monthly dose provides protection from fleas & ticks for a full 30 days
- Even indoor dogs need flea and tick control because you or other pets in the household may bring fleas into the home; These fleas can lead to a flea infestation
- FRONTLINE Plus also comes in a formula designed for dogs and puppies, 8 weeks and older, weighing 5 lbs and over, providing the same reliable flea & tick protection
$39.97
Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 1-Month Supply
- Advantage II Large Cat is a leading brand in cat flea treatment and prevention for large cats over 9 lbs., at least 8 weeks of age
- Vet-recommended, easy-to-apply monthly topical treatment – no hard-to-swallow pills, no prescription needed
- Delivers total flea protection – kills adult fleas, flea larvae and flea eggs through contact
- Same-day effectiveness – kills fleas within 12 hours of application and keeps working for 30 days
- Fragrance-free formula, waterproof after 24 hours of application
$16.98
Amazon Basics Flea Topical for Large Cats (over 9 pounds), 4 Count (Previously Solimo)
- FAST-ACTING FLEA MEDICATION FOR CATS: Eliminates fleas in just 12 hours, providing your large cat with swift relief from discomfort with our effective flea medication for cats
- LONG-LASTING FLEA PREVENTION FOR CATS: Protect your cat from infestations for up to 4 weeks with each application of this flea remover, providing continuous and reliable flea prevention for cats
- TOPICAL CAT FLEA DROPS FOR REINFESTATION: This cat flea medicine proactively kills reinfesting fleas within 2 hours, efficiently halting the flea lifecycle
- SUITABLE CAT FLEA MEDS FOR LARGE CATS: Specifically formulated for cats weighing over 9 pounds, offering targeted flea control with our dedicated cat flea meds for your furry companion
- SUITABLE CAT FLEA MEDS FOR LARGE CATS: Specifically formulated for cats weighing over 9 pounds, offering targeted flea control with our dedicated cat flea meds for your furry companion
$23.27
Seresto Cat Vet-Recommended Flea & Tick Treatment & Prevention Collar for Cats | 8 Months Protection
- Vet-recommended, premium flea & tick protection for cats & kittens without the price tag
- Long-lasting flea and tick collar kills & repels fleas for 8 continuous months
- Seresto is the #1 veterinarian recommended flea & tick collar*
- Starts working within 24 hours to kill & repel fleas and ticks by contact so pests don’t have to bite your cat to die
- Hassle-free, non-greasy, easy-to-use flea & tick protection
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Amazon Basics Flea and Tick Topical Treatment for Cats (over 1.5 pounds), 3 Count (Previously Solimo)
- Same product, new look―This product is identical in manufacturing and formulation as the Solimo brand
- Amazon Basics Flea & Tick starts eliminating fleas and ticks within 24 hours of treatment
- Active ingredients prevent flea infestations by killing flea eggs, flea larvae, mosquitos, biting flies and chewing lice
- One application provides up to 30 days of protection
- Waterproof: 24 hours after application your pet's treatment is protected against rain and water activities
$16.19
SALE
−$2.00
Flea and Tick Prevention for Cats & Kittens: Waterproof Topical Cat Flea and Tick Treatment – Fast-Acting & Long-Lasting At Home Flea Control for Cats Over 1.5 lbs and 8 Weeks or Older – 6-Dose Supply
- Flea & Tick Treatment for Cats: Our cat flea and tick treatment is formulated with vet-approved ingredients to quickly treatment fleas, ticks, larvae, and eggs, providing up to 30 days of continuous protection against
- Safe & Gentle for All Cats: Designed specifically for cats, our formula is safe for felines weighing over 1.5 lbs, making it suitable for kittens, adult cats, and senior cats. Gentle and non-irritating, it's ideal for cats with sensitive skin.
- Easy-to-Use: Our topical cat flea treatment is applied directly to the shoulder blades, eliminating the stress of administering oral medications. A simple, mess-free solution for effective flea and tick control.
- Everyday Protection: Our flea treatment for cats becomes waterproof 24-48 hours after application, allowing your cat to bathe and play as usual without compromising effectiveness—protection that lasts an entire month.
- Prevents Reinfestation: Not only does it eliminate existing fleas and ticks, but it also prevents new infestations by disrupting the parasite life cycle. A complete flea and tick prevention for cats solution for long-term health and comfort.
$26.99
SALE
−$1.08
Hartz UltraGuard Topical Flea & Tick Prevention for Cats and Kittens - 3 Monthly Treatments
- Topical drop formula kills fleas and deer ticks
- Includes 3 monthly treatments in easy to apply, single dose tubes
- Repels mosquitoes for 18 days
- For use on cats and kittens 12 weeks and older weighing 5 pounds and over
$5.44
TevraPet Actispot II Flea Treatment for Large Cats 9+ lbs | 6 Doses | Powerful Prevention and Control
- POWERFUL FLEA KILLING TREATMENT FOR LARGE CATS: TevraPet Actispot II is a waterproof topical for cats that kills fleas, flea eggs, and flea larvae for up to 30 days after each application
- VET APPROVED FORMULA: TevraPet Actispot II uses Imidacloprid and Pyriproxyfen - the same safe and effective active ingredients found in Advantage II - but costs far less. Every cat deserves veterinarian quality treatment, Actispot II helps you provide the same level of care without breaking the bank
- FAST ACTING AND LONG-LASTING WITH NO BITING REQUIRED: TevraPet Actispot II REPELS and KILLS fleas on contact, without your cat being exposed to bites. Begins killing within 24 hours of application, and starts repelling immediately. Other oral flea tablets, pills, and chews require that your pet is bitten by a pest before the meds can start working, potentially exposing your kitty to flea borne diseases
- BREAK THE CYCLE, PREVENT REINFESTATION: Unlike other flea medications that only temporarily control fleas, Actispot II flea treatment stops infestations dead in their tracks by effectively breaking the flea life cycle. Actispot II safely kills flea eggs and larvae to prevent re-infestation so your cat can get on with napping in the sun and strolling (or stalking!) through the garden
- EASY-TO-USE, MADE IN AMERICA: We proudly make every dose of Actispot II here in the USA and rigorously test for quality and potency. Each package comes with six (6) easy to apply, fully waterproof topical applications that ensure your friend has safe and reliable flea protection and control for up to six (6) months
$29.97
Advantage II Small Cat Vet-Recommended Flea Treatment & Prevention | Cats 5-9 lbs. | 1-Month Supply
- Advantage II Small Cat is a leading brand in cat flea treatment and prevention for small cats 5-9 lbs., at least 8 weeks of age
- Vet-recommended, easy-to-apply monthly topical treatment – no hard-to-swallow pills, no prescription needed
- Delivers total flea protection – kills adult fleas, flea larvae and flea eggs through contact
- Same-day effectiveness – kills fleas within 12 hours of application and keeps working for 30 days
- Fragrance-free formula, waterproof after 24 hours of application
$16.98
CAPSTAR (nitenpyram) Oral Flea Treatment for Cats, Fast Acting Tablets Start Killing Fleas in 30 Minutes, Cats 2-25 lbs, 6 Doses
- CAPSTAR (nitenpyram) starts killing adult fleas in just 30 minutes
- With one dose of CAPSTAR, you can watch the dead fleas fall off your pet
- If your pet gets reinfested with fleas, simply give another dose as often as once a day
- CAPSTAR is a fast, effective cat flea treatment that is available over the counter
- CAPSTAR Oral Flea Treatment for Cats (11.4 mg) is safe for cats and kittens 4 weeks and older that weigh 2-25 pounds
$39.98
Last update on 2025-05-02 / Affiliate links / Images from Amazon Product Advertising API