Nighttime cough medicine is essential for those seeking relief from persistent coughs that disrupt sleep. In 2025, the market offers a variety of effective options designed to soothe throats and suppress coughs, allowing for a restful night. From natural remedies to over-the-counter solutions, these medicines cater to different needs and preferences, ensuring that everyone can find the right product for their nighttime discomfort. Whether you prefer syrups, lozenges, or herbal blends, the best nighttime cough medicines of the year promise to provide the relief you need for a peaceful night's sleep.
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−$1.27
Robitussin Maximum Strength Nighttime Cough DM Max, Adult Formula, Berry Flavor - 8 Fl Oz Bottle
- One 8 fl oz bottle of Robitussin Maximum Strength Nighttime Cough DM Max, Adult Formula, Berry Flavor
- Provides cough relief as well as relief from symptoms due to hay fever or other upper respiratory allergies
- Liquid cough suppressant that is easy and quick to take
- Robitussin Nighttime DM Cough Medicine provides soothing relief in a great-tasting, berry flavor
- Nighttime cold medicine formulated to control your impulse to cough to help you sleep
$11.22
Amazon Basic Care Night Time Cold & Flu Liquid, Cherry, 12 fl oz (Pack of 1)
- ACTIVE INGREDIENTS: Active ingredients are Acetaminophen 650 mg, Dextromethorphan HBr 30 mg, and Doxylamine succinate, 12.5 mg. Compare to the active ingredients of Vicks NyQuil Cold & Flu
- RELIEVES COLD & FLU SYMPTOMS: Amazon Basic Care Nighttime Cold & Flu Relief provides multi-symptom relief by helping with common symptoms such as aches, fever, cough, sneezing and runny nose
- NIGHTTIME COLD AND FLU RELIEF: Amazon Basic Care Nighttime Cold and Flu Relief relieves cold and flu symptoms so you can rest through the night.
- EFFECTIVE: Acts as a pain reliever, fever reducer, cough suppressant and antihistamine.
- GLUTEN FREE: This product is Gluten Free. Contains 10% ALCOHOL.
$7.34
Quality Choice Adult Nighttime Cough Medicine, Cherry Flavored Night Time Cold and Flu Relief, Cough Syrup for Runny Nose & Sneezing, for Better Sleep, 8oz Bottle of Cherry Liquid Medicine
- Compares to the active ingredients in Vicks Nyquil Cough. Contains both Active Ingredients Dextromethorphan Hbr as a Cough Suppressant, as well as Doxylamine Succinate as an Antihistamine, Cold Medicine for Cold and flu, as well as a Cough Syrup Allergy Medicine.
- Nighttime Cough Relief: Our cough syrup provides fast relief for cough, runny nose, sneezing, Throat and Bronchial irritation, allowing you to sleep better. The 8-ounce bottle of cough medicine will leave the soothing feeling commonly left by cough drops or in this case cherry cough drops.
- Adult Targeted: This cough syrup is designed for adults and children aged 12 and over. Night time cough medicine for adults by Quality Choice is considered regular strength. Visit our Amazon store full of over-the-counter medication for other Severe or maximum strength cough suppressant for adults.
- Breathe Easy: Our syrup works to help you breathe easily and restfully. It's your all-in-one cold medicine, or substitute cough drops for adults. Sore throat relief that helps you to breath right and rest easily. An effective cold medicine for adults,
- Committed Brand: Quality Choice Provides health care products such is this hsa and fsa eligible item through there Amazon store. Flu Medicine for Adults, Cold and Flu, Digestive Health, First Aid, Vitamins, Pain Relief and much more for Men, Women, Adults, and children on the Amazon Store.
$8.49
Mucinex Nightshift Sinus, Cold And Flu Cough Medicine For Adults, Powerful Nighttime Sinus Medicine For Sinus Relief, Sore Throat Relief, Cough Suppressant & Nasal Decongestant For Adults, 6 Fl Oz
- COUGH MEDICINE ADULTS: Tackle nighttime coughing woes head-on with Mucinex Nightshift Sinus; This liquid formula helps to relieve your worst nighttime sinus and nasal congestion symptoms, so you can wake up ready to conquer the day
- COLD MEDICINE: Find relief from fever, headache, minor aches, sore throat, cough, sneezing, and runny nose with Mucinex Nightshift Sinus—a powerful liquid formula designed to tackle nighttime sinus symptoms effectively
- NIGHTTIME COLD AND FLU SYMPTOM RELIEF: Mucinex Nightshift Sinus helps to reduce fever, relieve headache, minor aches and pains, sore throat, coughing, sneezing, runny nose for a better morning
- SINUS RELIEF + SORE THROAT RELIEF: Mucinex Nightshift is a powerful sinus medicine that provides sinus relief & sore throat relief; Contains Acetaminophen which helps reduce fever & relieves minor aches & pains including sore throat pain
- MUCINEX NIGHTSHIFT SINUS ACTIVE INGREDIENTS: Contains Acetaminophen - Pain reliever and fever reducer; Dextromethorphan HBr - Cough suppressant; Phenylephrine HCl - Nasal Decongestant; Triprolidine HCl – Antihistamine
$13.97
Tylenol Extra Strength Severe Cough + Sore Throat Nighttime Liquid Cold Medicine, Multi-Symptom Cold Relief, Acetaminophen Pain Reliever, Dextromethorphan HBr, Doxylamine Succinate, 8 Oz.
- 8-fluid ounce bottle of Tylenol Extra Strength Severe Cough + Sore Throat Nighttime Liquid Cold Medicine with acetaminophen for multi-symptom cold & flu, cough & sore throat relief
- The extra strength nighttime relief liquid is formulated to temporarily reduce fevers & relieve common cold or flu symptoms such as minor body aches & pains, headache, sore throat & cough
- Each dose of Tylenol Extra Strength Nighttime liquid contains 1,000 mg of acetaminophen, a pain reliever & fever reducer, 30 mg of dextromethorphan HBr, a cough suppressant, as well as 12.5 mg of doxylamine succinate, an antihistamine
- Take 30 mL of Tylenol Extra Strength liquid in the dosing cup provided every 6 hours while symptoms last. Do not take more than 90 mL in 24 hours, unless directed by a doctor
- From the #1 doctor recommended pain relief brand, Tylenol Extra Strength Severe Cough + Sore Throat Nighttime liquid cold medicine can be used by adults & children 12 years & older for cough & sore throat relief at night
$9.78
Robitussin DM Max Cough Plus Chest Congestion and Robitussin Maximum Strength Nighttime Cough DM, Adult Formulas - 2 x 8 Fl Oz Bottles
- One 8 fl oz bottle of Robitussin Adult Maximum Strength Cough Plus Chest Congestion DM Max and One 8 fl oz bottle of Maximum Strength Nighttime Cough DM
- Robitussin Cough Plus Chest Congestion daytime cold medicine delivers temporary relief from cough and chest congestion
- Robitussin nighttime cold medicine for adults contains an antihistamine for relief of runny nose and sneezing and a cough suppressant to control your cough so you can sleep
- Liquid cough suppressant for adults that's easy to measure and administer
- Raspberry for daytime and Wildberry for nighttime cough medicine
$23.99
Nature's Way Boericke & Tafel Nighttime Cough & Bronchial Syrup, Cough Suppressant, Promotes Restful Sleep, 8 Fl. Oz
- Nighttime cough and bronchial syrup.
- Homeopathic syrup helps relieve coughs, clear bronchial congestion, and soothe your throat
- A blend of homeopathic ingredients helps support restful sleep.
- Non-narcotic.
- No artificial colors.
$16.77
GoodSense Nighttime Cold and Flu Liquid Medicine, 6 Hour Relief of Fever, Sore Throat, Sneezing, Runny Nose, Cough and Aches, Cherry Flavor, 12 Fl Oz
- ACTIVE INGREDIENTS: Compare to the active ingredients of NyQuil Cold and Flu: acetaminophen (pain reliever and fever reducer), dextromethorphan HBr (cough suppressant), and doxylamine succinate (antihistamine)
- POWERFUL NIGHTTIME RELIEF: Each dose relieves minor aches and pains, fever, sore throat, sneezing, runny nose and cough for up to 6 hours
- MAXIMUM STRENGTH: This flu and cold medicine provides maximum strength, multi-symptom relief to help you sleep
- COUGH SYRUP: The cough suppressant calms your nighttime coughing so you can rest; contains 10% alcohol
- AGES 12 AND OLDER: This cherry flavor cold and flu medicine is safe for adults and children ages 12 and over; gluten free
$5.99
Safetussin PM Nighttime Cough + Cold Relief 8oz Liquid
- NIGHTTIME COUGH RELIEF: Safetussin PM is a pharmacist-developed cough medicine that is safe for patients with diabetes & high blood pressure because it’s free of sugar, alcohol, dye, decongestants, & gluten!
- COUGH RELIEF TO HELP YOU REST: Pharmacist recommended Safetussin PM provides up to 8 hours of cough relief to help you rest when you have the common cold.
- THE CLEAR CHOICE: Safetussin PM Cough Syrup helps temporarily relieve cold symptoms such as cough, runny nose, & sneezing without unwanted additives or ingredients found in other cold medicines.
- SAFE & EFFECTIVE: Safetussin is formulated with dextromethorphan & doxylamine succinate to treat nighttime cough in adults with high blood pressure or diabetes or those who want safe PM cough relief without decongestants or sugar.
- SELF-CARE SOLUTIONS: At Kramer Laboratories we focus on consumer needs to help provide innovative solutions to everyday healthcare problems. Try our full line of Safetussin cough syrups for adults.
$10.98
Last update on 2025-05-02 / Affiliate links / Images from Amazon Product Advertising API