Nasal decongestant spray is an essential remedy for anyone suffering from nasal congestion due to allergies, colds, or sinus infections. In 2025, the market offers a variety of effective options that provide quick relief and help you breathe easier. From popular brands to innovative formulations, these sprays are designed to reduce swelling in the nasal passages and improve airflow. Whether you prefer a natural solution or a medicated option, there’s a decongestant spray to suit your needs. Explore the top choices available this year to find the perfect fit for your congestion relief.
SALE
−$2.52
Vicks Sinex SEVERE Nasal Spray, Original Ultra Fine Mist, Decongestant Medicine, Relief from Stuffy Nose due to Cold or Allergy, & Nasal Congestion, Sinus Pressure Relief, 265 Sprays x 2
- Targets nasal congestion and sinus pressure at the source by reducing swelling in the sinuses
- Breathe better all day or all night long with Vicks Sinex Severe. For instant, 12-hour, nasal congestion and sinus pressure relief
- This powerful decongestant medicine be used to treat severe sinus congestion and pressure caused by a cold or seasonal allergy spell, Not intended for daily use
- Unlike nasal decongestant tablets, Vicks Sinex Severe Nasal Sprays works by delivering powerful decongestant medicine directly to your nasal membranes
- Vicks Sinex Severe Nasal Spray is HSA and FSA eligible, Check with your provider for more details
$14.97
Amazon Basic Care No Drip Severe Congestion Nasal Pump Mist Spray, 12 Hour Relief, Oxymetazoline HCl, Maximum Strength Plus Menthol, Steroid Free, 1 fl oz (Pack of 1)
- ACTIVE INGREDIENT: This nasal spray contains oxymetazoline HCl, a nasal decongestant and the doctor recommended adult nasal spray active ingredient (source: IQVIA physicians survey 2019), which compares to the active ingredient in Afrin No Drip. Offers maximum strength nasal congestion relief.
- 12 HOUR, MAXIMUM STRENGTH RELIEF: Amazon Basic Care Severe Congestion Nasal Spray, Oxymetazoline HCl provides 12 hours of maximum strength nasal congestion relief due to the common cold, hay fever and upper respiratory allergies.
- FAST NASAL CONGESTION RELIEF: Amazon Basic Care Severe Congestion Nasal Spray, Oxymetazoline HCl provides fast and powerful relief for colds and allergies. Temporarily relieves sinus congestion and pressure.
- NASAL RELIEF: Amazon Basic Care Severe Congestion Nasal Spray, Oxymetazoline HCl provides temporary nasal congestion relief by shrinking swollen nasal membranes so you can breathe more freely.
- NO DRIP NASAL SPRAY: This cold and allergy relief nasal spray won't drip down your nose or throat. Severe congestion formula pump mist. Safety Sealed. This product is gluten free. Contains Menthol.
$4.89
Mucinex Mucinex Severe Nasal Congestion Relief Clear & Cool Nasal Spray, Cooling Menthol Flavor (Pack Of 3), 3/4 Fl Ounce
- SINUS & ALLERGY RELIEF: Mucinex Sinus-Max Severe Nasal Congestion Relief helps relieve nasal congestion, sinus congestion and sinus pressure
- # 1 TRUSTED COLD BRAND: #1 Cold brand doctors trust*
- COOLING MENTHOL BURST: With an instant cooling menthol burst
- NASAL DECONGESTANT: Contains Oxymetazoline HCl, a topical nasal decongestant
- FAST ACTING RELIEF: Targeted Nasal Congestion relief
$28.77
Afrin No Drip Extra Moisturizing 12 Hour Nasal Congestion Relief Pump Mist, Sinus Spray Decongestant - 15 mL
- Afrin No Drip Extra Moisturizing is a nasal pump mist designed to relieve nasal congestion for up to 12 hours
- Nasal decongestant pump mist works instantly to provide nasal and sinus congestion relief caused by allergies or other nasal irritants.
- Medicated no drip nasal spray doesn’t drip from your nose or down your throat
- 12 hour medicated moisturizing nasal spray soothes dry nasal passages
- Use Afrin nasal mist as directed, spraying two or three times into each nostril for no more than three days
$9.46
Amazon Basic Care No Drip Nasal Spray, 12 Hour Nasal Decongestant, Pump Mist, Oxymetazoline HCl, Cold and Allergy Nasal Spray, 1 fl oz (Pack of 1)
- ACTIVE INGREDIENT: This nasal spray contains oxymetazoline HCl, the #1 doctor recommended adult nasal spray active ingredient (of U.S. physicians surveyed by an independent market research firm). Compare to the active ingredient in Afrin No Drip.
- SOOTHING 12 HOUR MAXIMUM STRENGTH RELIEF: Amazon Basic Care No Drip Nasal Spray, Oxymetazoline HCl provides 12 hours of maximum strength nasal congestion relief due to the common cold, hay fever and upper respiratory allergies.
- FAST NASAL CONGESTION RELIEF: Amazon Basic Care No Drip Nasal Spray, Oxymetazoline HCl provides fast and powerful relief for colds and allergies. Temporarily relieves sinus congestion and pressure.
- NASAL RELIEF: Amazon Basic Care No Drip Nasal Spray, Oxymetazoline HCl provides temporary nasal congestion relief by shrinking swollen nasal membranes so you can breathe more freely.
- NO DRIP NASAL SPRAY: This cold and allergy relief nasal spray won't drip down your nose or throat. Nasal decongestant pump mist. This product is gluten free.
$9.87
Amazon Basic Care Maximum Strength 12 Hour Nasal Spray, Oxymetazoline HCl Solution, Congestion Relief, Cold and Allergy Medicine, Decongestant, 1 fl oz (Pack of 1)
- ACTIVE INGREDIENT: This nasal spray contains oxymetazoline hydrochloride 0.05%, a nasal decongestant. Compare to the active ingredient in Afrin Original.
- PURPOSE: This nasal spray temporarily relieves nasal congestion, sinus congestion and pressure due to the common cold, hay fever and upper respiratory allergies.
- 12 HOUR RELIEF: Amazon Basic Care Maximum Strength Nasal Spray provides fast, powerful congestion relief for allergies and colds for up to 12 hours.
- FAST CONGESTION RELIEF: Provides fast and powerful nasal congestion relief for allergies and colds.
- FAST-ACTING NASAL DECONGESTANT clears stuffy nose due to upper respiratory allergies and the common cold.
$6.71
Afrin No Drip Severe Congestion Nasal Mist Twin Pack, Non-Drowsy, Fast-Acting Decongestant for Nasal Congestion and Sinus Pressure Relief, Adults and Children 6 and Older, .5 fl oz (Pack of 2)
- Ridiculously Fast Relief: Unblock your nose in seconds with Afrin No Drip Severe Congestion Nasal Mist, a fast-acting nasal pump mist decongestant providing sinus pressure and congestion relief with cooling menthol in a convenient twin pack
- Effective for Severe Congestion: This maximum strength nasal spray is perfect for relieving severe nasal congestion and sinus pressure caused by colds and allergies, offering quick and effective stuffy nose relief for adults and children 6 years and older
- No Drip Technology: Afrin's No Drip technology ensures the medicated mist stays where it's sprayed, providing effective nasal decongestion without the mess or discomfort of it dripping from your nose or down your throat
- Cooling Menthol Formula: Experience the soothing and cooling sensation of menthol while the powerful decongestant works to constrict blood vessels in the nasal passages and reduce swelling to help you breathe easier
- 12-Hour Non-Drowsy Decongestion: Experience long-lasting relief for up to 12 hours without drowsiness, perfect for both day and night use to alleviate nasal congestion and provide sinus pressure relief
$16.49
Vicks Sinex Severe Nasal Spray with Moisturizing Ultra Fine Mist, Decongestant for Stuffy Nose Relief from Cold, Allergy, Sinus Pressure - 265 Sprays
- Targets nasal congestion and sinus pressure at the source by reducing swelling in the sinuses
- Breathe better all day or all night long with Vicks Sinex Severe. For instant, 12-hour, nasal congestion and sinus pressure relief
- This powerful decongestant medicine be used to treat severe sinus congestion and pressure caused by a cold or seasonal allergy spell, Not intended for daily use
- Unlike nasal decongestant tablets, Vicks Sinex Severe Nasal Sprays works by delivering powerful decongestant medicine directly to your nasal membranes
- Vicks Sinex Severe Nasal Spray is HSA and FSA eligible, Check with your provider for more details
$10.46
SALE
−$0.51
GoodSense Maximum Strength Nasal Spray, Fast Powerful Congestion Relief For Colds and Allergies, 1 Fluid Ounce
- ACTIVE INGREDIENT: This nasal spray contains oxymetazoline hydrochloride 0.05%, a nasal decongestant. Compare to the active ingredient in Afrin Original
- PURPOSE: This nasal spray temporarily relieves nasal congestion, sinus congestion and pressure due to the common cold, hay fever and upper respiratory allergies
- 12 HOUR RELIEF: GoodSense Maximum Strength Nasal Spray provides fast, powerful congestion relief for allergies and colds for up to 12 hours
- FAST CONGESTION RELIEF: Provides fast and powerful nasal congestion relief for allergies and colds
- FAST-ACTING NASAL DECONGESTANT clears stuffy nose due to upper respiratory allergies and the common cold
$6.48
SALE
−$5.00
FamilyCare Nasal Relief Spray, Pump Mist, Anti-drip, Severe Congestion, (Oxymetazoline HCI) 12 Hours, 3 Pack
- 12 hour nasal relief
- severe congestion
- compare to afrin severe congestion
- pump mist
- anti-drip
$7.00
Last update on 2025-05-02 / Affiliate links / Images from Amazon Product Advertising API