Nasal congestion medicine for adults is essential for alleviating discomfort caused by allergies, colds, or sinus infections. In 2025, the market offers a variety of effective options, including decongestants like pseudoephedrine, antihistamines such as loratadine, and nasal sprays like oxymetazoline. These medications work by reducing swelling in the nasal passages, providing quick relief and improving overall breathing. Additionally, some products combine multiple active ingredients to tackle various symptoms simultaneously, making them a convenient choice for many adults. When selecting the right nasal congestion medicine, it's important to consider individual health needs and consult with a healthcare professional if necessary.
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−$3.02
Mucinex Sinus Max Severe Congestion & Pain Relief, Maximum Strength Nasal & Sinus Relief, Decongestant for Adults, Acetaminophen Pain Reliever, Guaifenesin Expectorant and Mucus Removal, 20 Caplets
- MAXIMUM STRENGTH RELIEF: Maximum Strength Mucinex Sinus-Max Severe Congestion & Pain helps relieve pain, headache, nasal congestion, sinus congestion and chest congestion.
- #1 TRUSTED COLD AND COUGH BRAND: #1 Cold and Cough brand doctors trust*
- PAIN RELIEVER: Contains Acetaminophen which relieves minor aches and pains
- EXPECTORANT: Contains Guaifenesin that thins and loosens mucus; relieves chest congestion
- NASAL DECONGESTANT: Contains Phenylephrine HCl that provides relief for nasal congestion, sinus congestion and pressure
$10.97
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−$1.73
Benadryl Allergy Plus Congestion Ultratabs with Diphenhydramine HCl Antihistamine & Phenylephrine HCl Nasal Decongestant, Allergy & Sinus Congestion Relief Tablets, 24 ct
- 24-count pack of Benadryl Allergy Plus Congestion Ultratabs nasal decongestant & antihistamine allergy relief tablets containing both diphenhydramine HCl and phenylephrine HCl for allergy relief you can trust + fast congestion relief
- Formulated to alleviate allergy symptoms caused by hay fever & other upper respiratory allergies, Benadryl Allergy + Congestion dries runny, stuffy noses so you can breathe better & temporarily relieves common cold symptoms like sneezing & congestion
- This allergy medicine contains 25 mg of the antihistamine diphenhydramine HCl & 10 mg of the nasal decongestant phenylephrine HCl in every allergy relief tablet that work to help alleviate sinus congestion & allergy symptoms
- Get temporary relief of cold symptoms like runny nose, sneezing, nasal congestion & sinus pressure with a formula that offers a nasal decongestant & antihistamine in one tablet.
- From a doctor-recommended brand, this allergy medicine is suitable for ages 12 and up and provides safe & effective relief (when used as directed) from symptoms due to indoor & outdoor allergies as well as congestion due to the common cold
$7.29
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−$2.49
Sudafed PE Sinus Congestion Day + Night Maximum Strength Decongestant & Antihistamine Tablets with Phenylephrine HCl & Diphenhydramine HCl, Helps Nasal & Sinus Pressure & Congestion, 20 ct
- 20-count of Sudafed PE Sinus Congestion Day + Night Maximum Strength Decongestant Medicine Tablets to temporarily relieve sinus pressure and sinus congestion for both day and night
- Each multi-pack contains 20 tablets of nasal decongestant, with 12 Daytime and 8 Nighttime tablets for powerful symptom relief throughout the day and while you sleep
- Each daytime and nighttime dose contains 10 milligrams of the nasal decongestant phenylephrine HCl per tablet and each nighttime dose also contains 25 milligrams per tablet of the antihistamine diphenhydramine HCl
- Both formulas help relieve sinus pressure and sinus congestion, and nasal congestion due to the common cold, hay fever, or upper respiratory allergies. Nighttime tablets also relieve sneezing, runny nose, itchy, watery eyes and itchy throat or nose
- From the #1 pharmacist recommended brand among oral OTC decongestants, this maximum-strength formula can be used by adults and children 12 years and older for powerful symptom relief
$8.18
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−$1.50
Alka-Seltzer Plus Maximum Strength PowerMax Sinus Congestion & Pain Medicine, Day + Night Liquid Gels - Powerful Relief for Cold and Flu, + Sinus Congestion for Adults and Children 12+ Years, 24 Count
- Alka-Seltzer Plus Maximum Strength sinus, congestion and pain Powermax gels provide powerful fast relief *Use as directed.
- Sinus, congestion and pain relief Day and Night liquid gels should not be taken at the same time; Wait 4 hours after the last Night dose before starting Day product.
- Powerful relief, day or night, from your worst sinus, cold and flu symptoms
- Day time formula provides relief from fever, headache, nasal congestion, sinus congestion / pressure, minor aches and pains, cough, and sore throat. In addition to these symptoms, the Night-time formula also helps relieve runny nose & sneezing.
- Alka-Seltzer Plus Maximum Strength PowerMax Sinus Congestion and Pain Medicine is a powerful cold and flu medicine for adults and children 12 years and older.
$8.99
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−$1.02
Alka-Seltzer Plus Maximum Strength PowerMax Sinus Congestion and Pain Liquid Gels - Nasal Decongestant, Cough Suppressant, and Pain Relief for Adults and Children 12 Years and Older, 24 Count
- Alka-Seltzer Plus Maximum Strength Sinus Congestion and Pain relieving Powermax gels provide powerful fast relief *Use as directed.
- Alka-Seltzer Plus Maximum Strength PowerMax Sinus Congestion and Pain Liquid Gels provide fast relief from symptoms due to a cold or flu.
- The sinus congestion and pain liquid gels formula offers relief from minor aches and pains, fever, headache, cough, sore throat, nasal and sinus congestion.
- Relieve your worst symptoms of nasal & sinus congestion, headache, body pain and cough with Alka-Seltzer Plus congestion, pain relief, and sinus medicine for adults and children 12 years and older
- Alka-Seltzer Plus PowerMax Sinus Congestion and Pain Liquid Gels contain a combination of pain relievers, cough suppressant, and nasal decongestants to effectively target sinus congestion, pain, fever, cold and flu symptoms
$9.47
Afrin No Drip Severe Congestion Nasal Mist Twin Pack, Non-Drowsy, Fast-Acting Decongestant for Nasal Congestion and Sinus Pressure Relief, Adults and Children 6 and Older, .5 fl oz (Pack of 2)
- Ridiculously Fast Relief: Unblock your nose in seconds with Afrin No Drip Severe Congestion Nasal Mist, a fast-acting nasal pump mist decongestant providing sinus pressure and congestion relief with cooling menthol in a convenient twin pack
- Effective for Severe Congestion: This maximum strength nasal spray is perfect for relieving severe nasal congestion and sinus pressure caused by colds and allergies, offering quick and effective stuffy nose relief for adults and children 6 years and older
- No Drip Technology: Afrin's No Drip technology ensures the medicated mist stays where it's sprayed, providing effective nasal decongestion without the mess or discomfort of it dripping from your nose or down your throat
- Cooling Menthol Formula: Experience the soothing and cooling sensation of menthol while the powerful decongestant works to constrict blood vessels in the nasal passages and reduce swelling to help you breathe easier
- 12-Hour Non-Drowsy Decongestion: Experience long-lasting relief for up to 12 hours without drowsiness, perfect for both day and night use to alleviate nasal congestion and provide sinus pressure relief
$16.49
Amazon Basic Care Tussin Severe CF Max Syrup, Multi-Symptom Cough, Cold and Flu Liquid Medicine, Non-Drowsy, Relieves Cough, Sore Throat, Body Aches, Fever, Nasal and Chest Congestion, 8 fl oz
- ACTIVE INGREDIENTS: This cold medicine contains a pain reliever/fever reducer, cough suppressant, expectorant and nasal decongestant. Compare to the active ingredients in Robitussin Severe Multi-Symptom Cough Cold + Flu.
- MAXIMUM STRENGTH: This cold medicine provides maximum strength relief of multiple cold and flu symptoms such as cough, nasal congestion, sinus congestion and pressure, minor aches and pains, sore throat, headache and temporarily reduces fever.
- MUCUS RELIEF: Take this cold medicine to help loosen phlegm (mucus) and thin bronchial secretions to drain bronchial tubes and make coughs more productive.
- NON-DROWSY: This non-drowsy cold and flu medicine provides relief for adults and children age 12 years and over. Dosage cup included.
- GREAT TASTING COLD MEDICINE: Amazon Basic Care Tussin CF Max, Multiple Symptom Cough Cold & Flu is gluten free, sugar free and alcohol free. Maximum strength claim based on maximum levels of active ingredients per 4 hour dose.
$5.01
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−$1.02
Alka-Seltzer Plus Maximum Strength, Cough Mucus & Congestion, Day+Night PowerMax Liquid Gels - Fast-Acting Cough and Congestion Medicine for Adults and Children 12 Years and Older, 24 Count
- Alka Seltzer Plus maximum strength Cough, Mucus and Congestion Day+Night Powermax gels provide powerful, fast relief from cough, congestion, cold and flu symptoms *Use as directed.
- Provides effective daytime relief from cough, congestion, cold and flu symptoms for adults and children 12 years and over. Relieves nasal congestion, cough, headache, chest congestion, body ache, sore throat, sinus pressure, congestion and fever
- Provides powerful maximum strength nighttime relief from cough, congestion, cold and flu symptoms, for adults and children 12 years and over Relief from nasal congestion, cough, headache, body ache, sore throat, sinus congestion, runny nose, sneezing and fever
- Fast cough, mucus and congestion relief so you can get back to your busy life
- Each cough, mucus and congestion medicine box containing 24 Liquid gels, 1 dose (2 Liquid gels). use as directed
$9.47
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−$5.10
Mucinex Fast-Max Severe Congestion & Cough Medicine, Maximum Strength Symptom Relief, Over-The-Counter Medication, Cold Medicine, Cough Suppressant, Expectorant, Nasal Decongestant, FSA/HSA, 6 FL OZ
- COUGH COLD AND FLU MEDICINES FOR ADULTS: Maximum Strength Mucinex Fast Max Severe Congestion & Cough provides powerful multi-symptom relief for your worst symptoms including cough, chest congestion, and nasal congestion
- EXPECTORANTS AND DECONGESTANTS FOR ADULTS : Maximum Strength Mucinex Fast-Max Severe Congestion & Cough has a triple action formula that relieves nasal & chest congestion, controls cough & thins & loosens mucus to help clear lungs of excess mucus
- POWERFUL COUGH & COLD ACTIVE INGREDIENTS: Contains Dextromethorphan HBr - Cough suppressant; Guaifenesin - Expectorant; Phenylephrine HCI - Nasal decongestant
- TRUSTED BRAND: Mucinex is the #1 Cough & Cold Brand Doctor's Trust* and is also the #1 Pharmacist Recommended Brand**; Get the brand that doctors trust and recommend!
- USAGE: Use as directed; For ages 12+ years
$12.88
Last update on 2025-05-03 / Affiliate links / Images from Amazon Product Advertising API