Methylfolate supplements for MTHFR are essential for individuals with this genetic mutation, as they help support optimal folate levels and overall health. In 2025, the market offers a variety of high-quality methylfolate supplements that cater to different needs and preferences. These supplements are designed to enhance absorption and bioavailability, ensuring that your body receives the necessary nutrients to function effectively. Whether you're looking for a vegan option, a specific dosage, or additional vitamins, there are top-rated products available to suit your requirements.
THORNE 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation, and Homocysteine Levels* - 60 Capsules - 5-MTHF 1mg
- Healthy Methylation: A breakthrough in active folate supplementation for healthy methylation*
- Positivity: Supports a healthy outlook*
- Nerves & Circulation: Supports healthy blood vessel and nerve function*
- Cardiovascular Support: Providing the nutritional cofactors for optimal homocysteine metabolism supports cardiovascular health*
- Trusted: Thorne is chosen by champions and trusted by 100+ pro teams. Thorne is the only supplement manufacturer to collaborate with Mayo Clinic on wellness research and content. Thorne is also a proud partner of 11 U.S. Olympic Teams
$24.00
Seeking Health Methyl B12 with L-Methylfolate - MTHFR Support Supplement - Methylation Support Supplement - Lozenges to Support Brain Health & Energy - 60 Lozenges
- HEALTHY ENERGY LEVELS: Methyl B12 with L-Methylfolate by Seeking Health provides 1,360 mcg DFE (800 mcg) of pure non-racemic L-methylfolate in an easy-to-take lozenge, along with two active “coenzyme” forms of vitamin B12 to give you the energy you need.*
- HEALTHY MOOD AND FOCUS: Experience a supported healthy mood, focus, energy, and clarity. Note: This is a situational supplement; only take it when you feel that you need it. Other than those times, don’t take it, or as directed by your healthcare professional.*
- IDEAL FOR MTHFR GENE MUTATION: By taking this combination of methylated nutrients—methylfolate and methylcobalamin—in Active Vitamin B12 with L-5-MTHF, your methylation pathway is supported and your MTHFR gene mutation symptoms are supported.*
- LOZENGE: This easy-to-take and great-tasting lozenge isn’t your typical daily supplement. You should take it on an as-needed basis, or as directed by your healthcare professional. When you have a slight brain fog or feel unfocused, or fatigued, start with a small portion.*
- CONSISTENT QUALITY: At Seeking Health, every ingredient is carefully sourced, researched, and tested. Each meets strict specifications for manufacturing standards before any ingredient is allowed for use. We use only the highest-quality ingredients.
$23.90
L Methylfolate 7.5mg plus Methyl B12 - Active 5-MTHF Form, MTHFR Supplement - Bloodstream Ready Methylated Folate + B12 Cofactor - Supports Mood, Homocysteine Methylation, Cognition (60 Capsules)
- DAILY DOSE of 7.5 MG L METHYL FOLATE : Provides dose of 7.5mg L Methylfolate in the 5-MTHF calcium salt form. This is the most active form of Folate.
- ESSENTIAL METHYL B12 COFACTOR: Methylcobalamin B12 and Methylfolate have co-dependent relationships. Both are crucial in the body's methylation processes. Methylfolate cannot complete the methylation process and breakdown of homocysteine without Methyl B12.
- ACTIVE FORM OF FOLATE: Methylfolate is the most metabolically active and bloodstream-ready form of Folate or Folic Acid (vitamin B9). It is immediately absorbed into the bloodstream because it does not require processing or breakdown by the body. This is crucial for those with methylation issues that cannot properly process folic acid.*
- BRAIN, MOOD & ENERGY SUPPORT: Essential to neurotransmitters production involved in concentration, sleep, energy, hormones & mood.*
- CARDIOVASCULAR, NITRIC OXIDE & NERVE SUPPORT: Supports heart health and nerve function by supporting healthy homocysteine levels and nitric oxide production.
$19.99
THORNE 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation, and Homocysteine Levels* - 60 Capsules - 5-MTHF 5mg
- Healthy Methylation: A breakthrough in active folate supplementation for healthy methylation*
- Positivity: Supports a healthy outlook*
- Nerves & Circulation: Supports healthy blood vessel and nerve function*
- Cardiovascular Support: Providing the nutritional cofactors for optimal homocysteine metabolism supports cardiovascular health*
- Trusted: Thorne is chosen by champions and trusted by 100+ pro teams. Thorne is the only supplement manufacturer to collaborate with Mayo Clinic on wellness research and content. Thorne is also a proud partner of 11 U.S. Olympic Teams
$66.00
SALE
−$1.85
Igennus Super B-Complex Methylated B Vitamins, Sustained Release, Clean Label, MTHFR Supplement with Methylfolate & B12 Methylcobalamin, Vegan, Lab Verified, 60 Small Tablets
- METHYLATED B VITAMINS AND FOLATE that the body utilises immediately: bioavailable folate as methylfolate & methylcobalamin (Vit B12) - no poorly absorbed cyanocobalamin*
- HIGH STRENGTH, SUPER ABSORBABLE B complex vitamins including thiamine (B1), Riboflavin-5-phosphate (B2), Nicotinamide (flush free Niacin - B3), Calcium D-pantothenate (B5) & D-Biotin (B7)*
- SUSTAINED RELEASE technology gradually releases vitamins (important for optimising B12 levels), whilst twice daily dosing provides all-day nutrient coverage*
- INTENSIVE HEALTH SUPPORT for energy metabolism, the immune and hormonal systems, homocysteine regulation, nutrient metabolism, heart function and psychological function*
- PURE & CLEAN: vegan, non-GMO, hypoallergenic ingredients, no unpleasant fillers (silicon dioxide, magnesium stearate or titanium dioxide). Lab verified, USA & UK GMP manufactured. Small 9mm tablets
$13.10
Nature's Fusions Nutri 5-MTHF L Methylfolate 1MG - 4 Month Supply, 120 Vegan Tablets - Methylated Folate Supplement - Cognitive Function, Heart Health, Prenatal Support - Methylated Folic Acid
- SUPERIOR STRENGTH 1MG: Our Methylated Folate supplement delivers an impressive 1 MG per serving, giving you the advantage of a potent and highly effective formula. This strength is carefully selected to provide optimal support for your body's methylation processes, which are crucial for energy production, DNA synthesis, and neurotransmitter regulation.
- 120 SERVINGS: Each bottle of our premium 5-MTHF supplement contains a generous supply of 120 vegan tablets, providing you with long-lasting support. Vegan-friendly and free from any animal-derived ingredients, our tablets are carefully crafted to cater to your specific dietary preferences while offering maximum efficacy.
- BIOAVAILABLE AND PURE: Our 5-MTHF supplement features the bioactive form of folic acid, known as 5-methyltetrahydrofolate (5-MTHF). This highly bioavailable and pure form of methylated folate is readily utilized by the body, ensuring efficient absorption and utilization.
- OPTIMAL METHYLATION SUPPORT: Methylation is a crucial process that contributes to various aspects of overall health. Our 5-MTHF supplement assists in supporting optimal methylation, which is essential for maintaining healthy homocysteine levels, promoting cardiovascular wellness, and supporting cognitive function.
- 3RD PARTY LAB TESTED IN THE USA: We have our own GMP and FDA registered Food-Grade facility in the USA. All our products are 3rd-Party tested to guarantee purity. Satisfaction Guaranteed: At Nutri we guarantee almost everything Forever. Please contact us for any refund or return issue as Amazon "does not allow" returns on supplements, but we do.
$9.95
Seeking Health L-5-MTHF, Supports Healthy Methylation, Easily Absorbed Methyl Folate Supplement, MTHFR Support Supplement, 1,700 mcg DFE, Vegetarian (60 Capsules)
- Targeted support: Each bottle contains 60 capsules of 1,700 mcg DFE L-5 MTHF, which may support MTHFR gene mutations, healthy cognition and mood, methylation, and provide homocysteine support
- Easily absorbed: Seeking Health L-5-MTHF is a gentle, bioavailable form of folate that is optimized for easy absorption and is suitable for vegans and vegetarians
- Prenatal support: Methylated folate may support pregnant women, a healthy nervous system, and fetal development
- Free from: Eggs, fish, gluten, GMO, milk, peanuts, shellfish, soy, tree nuts, wheat, artificial colors, artificial flavors, and artificial preservatives
- Consistent quality: At Seeking Health, every ingredient is carefully sourced, researched, and tested. Each meets strict specifications for manufacturing and quality standards before any ingredient is allowed for use
$20.00
L-Methylfolate 15mg plus Methyl B12, D3, Taurine & NAC | 5-MTHF (Bioactive B9) Premium-Grade | Methylated Vitamins to Support Mood, Nerve Health & Methylation* | Methylfolate Supplement | 60 Capsules
- SUPERIOR 5-MTHF FORM: Our L-Methylfolate 15 mg is delivered in calcium salt form, and unlike standard folic acid, this is the most active form of folate (vitamin B9) and is readily available for your body to absorb.*
- ENHANCED WITH METHYL B12: L-Methyl Folate and Methylated B12 are crucial co-factors in the methylation cycle. These two nutrients work synergistically in many biochemical processes.*
- 5-IN-1 FORMULA: Unlike our competitors, we go beyond the standard methylated folate and b12 combo to provide a more complete formula. Our supplement is further enhanced with NAC, Taurine, and Vitamin D3.
- BRAIN, MOOD, & ENERGY SUPPORT: Promote brain function, mood stability, and energy production by aiding neurotransmitter synthesis and optimizing methylation processes.*
- THIRD-PARTY TESTED: Tested & trusted ingredients. All Natural Approach ingredients are third-party tested for quality & purity before and after the manufacturing process to ensure the highest efficacy and safety. Manufactured in a USA cGMP-Certified facility.
$23.95
FITO MEDIC'S Lab | methylfolate |120 Capsules | 15000 mc |15 mg | folate | folate Supplement | Methyl folate | methylfolate Supplement | mthfr Supplement | Ultra high Absorption.
- - Introducing methylfolate, your ultimate solution for folate deficiency! Our lab-formulated supplement contains 15000 mc/15 mg of pure methylfolate.
- - Our product boasts of ultra-high absorption, ensuring that your body is able to process and utilize the supplement effectively.
- - Each bottle of methylfolate contains 120 capsules, providing a convenient and easy-to-use solution for your daily folate needs.
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METHYLFOLATE SUPPLEMENT 5-MTHF Supplement (200 Servings 1700 DFE) Methylated B9 Vitamin, Active Folic Acid/Methylated Folate Supplement Drops
- WHAT IS METHYLATED FOLATE? Methylated Folate, also known as 5-MTHF (5-methyltetrahydrofolate), is the active form of Vitamin B9 that the body can immediately use without conversion.
- MTHFR MUTATION: For individuals with genetic variations like the MTHFR mutation, the body's ability to process standard Folic Acid is hindered. Methylfolate, being a methylated and already active version of Folate, circumvents this conversion challenge
- JUST METHYLFOLATE: Oral Absorption for easy dosaging and intake
- 200 SERVINGS: Safe for adults to children/kids. A 7 mg and 15 mg dosages which is very high. Unless recommended by your doctor, starting at less than 1 MG (1000 mcg) and then re-assessing is much more sensible
- LIGHT STRAWBERRY NATURAL FLAVOR: Simple Ingredients with no artifical flavors or colors. Zero Sugar
$11.99
Last update on 2025-05-02 / Affiliate links / Images from Amazon Product Advertising API