Methylfolate supplements are essential for those seeking to enhance their folate levels, particularly for individuals with MTHFR gene mutations. In 2025, the market offers a variety of high-quality methylfolate supplements that cater to different needs and preferences. From well-known brands to innovative newcomers, these supplements provide bioavailable forms of folate that support overall health, energy levels, and mood stability. When choosing the right methylfolate supplement, it's crucial to consider factors such as dosage, additional ingredients, and customer reviews to ensure you find the best option for your health journey.
L Methyl Folate 15mg Plus Methyl B12 Cofactor – High Potency, Active 5-MTHF Form - Supports Mood, Methylation, Cognition – Bioactive Forms of Vitamin B9 & B12 (60 Capsules – 60 Servings)
- HIGH-POTENCY: Provides a high-potency serving of 15mg L-Methylfolate in the 5-MTHF calcium salt form. This bioactive form of folate is readily utilized by the body.
- VITAL METHYL B12 COFACTOR: Methylcobalamin B12 and Methylfolate have co-dependent relationships that work together in the body's methylation processes. Methylfolate cannot complete the methylation process and breakdown of homocysteine without Methyl B12.
- ACTIVE FORM OF FOLATE: Methylfolate is the most metabolically active and bloodstream-ready form of Folate or Folic Acid (vitamin B9). It is immediately absorbed into the bloodstream because it does not require processing or breakdown by the body. This is vital for those with methylation issues that cannot properly process folic acid.
- SUPPORTS BRAIN, MOOD & ENERGY HEALTH: Important for healthy neurotransmitter function linked to focus, energy, and a balanced mood.
- SUPPORTS CARDIOVASCULAR, NITRIC OXIDE & NERVE HEALTH: Helps maintain healthy homocysteine levels, promotes normal heart function, and supports nitric oxide production for overall circulatory and nerve well-being.
$21.97
L Methyl Folate 15mg Plus Methyl B12 Cofactor – Organic Berry Flavor, High Potency Liquid Sublingual Active 5-MTHF Form - Supports Mood, Methylation, Cognition – Bioactive Forms Vitamin B9 & B12 (1oz)
- HIGH-POTENCY: Provides a high-potency serving of 15mg L-Methylfolate in the 5-MTHF calcium salt form. This bioactive form of folate is readily utilized by the body.
- VITAL METHYL B12 COFACTOR: Methylcobalamin B12 and Methylfolate have co-dependent relationships that work together in the body's methylation processes. Methylfolate cannot complete the methylation process and breakdown of homocysteine without Methyl B12.
- ACTIVE FORM OF FOLATE: Methylfolate is the most metabolically active and bloodstream-ready form of Folate or Folic Acid (vitamin B9). It is immediately absorbed into the bloodstream because it does not require processing or breakdown by the body. This is vital for those with methylation issues that cannot properly process folic acid.
- SUPPORTS BRAIN, MOOD & ENERGY HEALTH: Important for healthy neurotransmitter function linked to focus, energy, and a balanced mood.
- SUPPORTS CARDIOVASCULAR, NITRIC OXIDE & NERVE HEALTH: Helps maintain healthy homocysteine levels, promotes normal heart function, and supports nitric oxide production for overall circulatory and nerve well-being.
$21.97
THORNE 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation, and Homocysteine Levels* - 60 Capsules - 5-MTHF 1mg
- Healthy Methylation: A breakthrough in active folate supplementation for healthy methylation*
- Positivity: Supports a healthy outlook*
- Nerves & Circulation: Supports healthy blood vessel and nerve function*
- Cardiovascular Support: Providing the nutritional cofactors for optimal homocysteine metabolism supports cardiovascular health*
- Trusted: Thorne is chosen by champions and trusted by 100+ pro teams. Thorne is the only supplement manufacturer to collaborate with Mayo Clinic on wellness research and content. Thorne is also a proud partner of 11 U.S. Olympic Teams
$24.00
SALE
−$8.53
NOW Foods Supplements, Methyl Folate 1,000 mcg, Metabolically Active Folate*, Co-Enzyme B Vitamin, 90 Tablets
- CO-ENZYME B VITAMIN/1,000 mg TABLETS: Methylfolate is the biologically active, naturally occurring form of folate that is used for fundamental body functions like normal cell division and the synthesis of neurotransmitters and DNA.
- METABOLICALLY ACTIVE FOLATE/SUPERIOR BIOAVAILABLITY: Quatrefolic is a patented form of methylfolate that has demonstrated bioavailability superior to that of folate from dietary sources.
- CERTIFICATIONS/CLASSIFICATIONS: Non-GMO, Vegan/Vegetarian
- GMP Quality Assured: NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods (for stability, potency, and product formulation).
- Packaged in the USA by a family owned and operated company since 1968
$13.46
Methylfolate 1,000mcg, 120 Capsules (Third Party Tested Methyl Folate Supplement) Methylated Folate is a More Active Form of Folate Than Folic Acid (Non-GMO, Vegan Safe) by Double Wood
- MORE ACTIVE FORM OF FOLATE: Recent research suggests that Methylfolate is a more active form of folate when compared to Folic Acid. Folic Acid is the synthetic form of Folate
- METABOLICALLY ACTIVE 5-MTHF (OPTIMIZED FOLATE): Methylfolate is the biological and active form of Folate. It is more immediately absorbed into the bloodstream and requires little processing by the body
- METHYLFOLATE vs METHYL B12: Methylfolate (known as B9) and Methyl B12 are the active forms of Folate and B12 and are readily used by the body compared to non-methylated forms of the same vitamins
- ROOTED IN QUALITY: Manufactured and Tested in the USA from Globally Sourced Ingredients. Double Wood's Methylfolate is manufactured and tested for microbes and heavy metals right here in the USA from Globally Sourced Ingredients. Plus,it is vegetarian, Non-GMO and gluten-free
- WE BOTTLE WELLNESS: At Double Wood we provide pure, potent supplements that deliver exceptional value, all backed by careful sourcing and rigorous third-party testing
$7.95
SALE
−$3.00
Nutricost Methylfolate 1000mcg, 120 Vegetarian Capsules - Gluten Free, Non-GMO
- 120 Capsules MethylFolate (120 Servings)
- 1,000mcg MethylFolate Per Serving
- Vegetarian Capsules
- Non-GMO & Gluten Free & 3rd Party Tested
- Made in a GMP Compliant, FDA Registered Facility
$12.95
Organic Methyl Folate 1000 mcg + Methyl B12 Cofactor (300 Servings) – Metabolically Active 5-MTHF Form, Organic Berry Flavor, Liquid Sublingual Form – Mood, Cognition, Methylation, Pregnancy (1oz)
- BIOLOGICALLY ACTIVE FORM OF FOLATE (1 mg or 1000 mcg) : L-Methylfolate is the biological active form of Folate. It immediately absorbs into bloodstream and requires no processing by the body. The 1 mg dose is ideal to address daily Folate nutritional needs.*
- ESSENTIAL METHYL B12 COFACTOR: Methylcobalamin B12 and Methylfolate have co-dependent relationships. Both are crucial in the body's methylation processes. Methylfolate cannot complete the methylation process and breakdown of homocysteine without Methyl B12.*
- ENHANCED SUBLINGUAL ABSORPTION, CHERRY FLAVOR: The liquid sublingual form of L-methylfolate immediately absorbs directly the into bloodstream with higher overall absorption.*
- SUPPORTS HEALTHY METHYLATION: The L Methyl Folate form of Folate is essential for healthy methylation especially for those with MTHFR gene.*
- PREGNANCY, BRAIN, MOOD, ENERGY SUPPORT, CARDIOVASCULAR: 1 mg of Methylfolate supports healthy baby development during pregnancy. It is also essential to neurotransmitters production involved in concentration, sleep, energy, hormones & mood.* Methylfolate also supports heart health and nerve function by supporting healthy homocysteine levels and nitric oxide production.*
$21.97
SALE
−$5.29
Carlyle L Methylfolate 15mg | 120 Capsules | Value Size | Max Potency | Optimized and Activated | Non-GMO, Gluten Free | Methyl Folate, 5-MTHF | by Opti-Folate
- L-METHYLFOLATE: A metabolically active form of Folic Acid, also known as Folate or B-9 Vitamin!
- COMPLETE FORMULA: Quick-release capsules deliver 25,000 mcg Folate (15 mg L-METHYLFOLATE)
- ROOTED IN WELLNESS: Carlyle provides premium, honest supplements in your pursuit to healthy living.
- CARLYLE MANUFACTURERS: Laboratory Tested, Trusted Ingredients, Superior Quality, 100% Guaranteed!
- NATURALLY FREE OF: Gluten, Wheat, Yeast, Lactose, Soy, Artificial Flavor, Preservatives and Non-GMO
$29.99
Life Extension Optimized Folate – L-methylfolate – Heart & Brain Support, Healthy Homocysteine Levels – Non-GMO, Gluten-Free, Vegetarian – 1700 mcg DFE, 100 Vegetarian Tablets
- Get a brain boost – Stay proactive about your brain health and support optimal cognitive function with this folate supplement. This 1700 mcg vitamin B formula helps maintain healthy cognition—especially as you age.
- Pump up the heart health – This 5-MTHF supplement is a cardiovascular health superstar! Folate helps maintain already-normal homocysteine levels, an important cardiovascular health marker. Folate is a great way to keep heart health in check.
- Metabolically active form – 5-MTHF, the metabolically active form of folate, is good for your heart and brain health. But not everyone can convert the dietary form of folate (known as folic acid) into 5-MTHF. This supplement provides folate’s 5-MTHF form.
- Ingredients matter – We use only the finest raw ingredients with the purity and potency you deserve. The majority of our products are non-GMO, gluten-free and manufactured in the USA—and a Certificate of Analysis is available for every one.
- Live your healthiest life – We believe the answers to a healthier life are within reach, and that scientific research is the key to getting us there. That’s why so many of our formulas feature specific ingredients and amounts based on scientific studies.
$10.99
Double Strength & Most Bioactive Methyl Folate! Uniquely Formulated with Highest Pharmaceutical Grade Methylcobalamin (B12), Niacin, B1, B2 B6. Works Synergistically for Max Results-3 Month Supply
- ♥ Lab tested and most powerful Methylfolate supplying essential support for DNA and neurotransmitter synthesis along with amino acid metabolism.
- ♥ Developed as most optimally absorbed and bioavailable 5-MTHF
- ♥ Delivering key supplementation for brain, heart and nerve function, as well as support for women who are pregnant and overall health
- ♥ Suitable for people who are diagnosed with MTHFR mutation
- ♥ To ensure purity and safety, our products are manufactured in a fully GMP-certified facility. Our product is third party tested to assure the quality and purity of each batch. All Made in USA.
$22.99
Last update on 2025-05-02 / Affiliate links / Images from Amazon Product Advertising API