Methylated vitamins are essential for optimal health, particularly for individuals with MTHFR gene mutations that affect folate metabolism. These vitamins, which include methylcobalamin (B12), methylfolate (B9), and other bioactive forms, support energy production, cognitive function, and overall well-being. In 2025, the best methylated vitamins on the market offer high bioavailability and are formulated to enhance absorption, making them a top choice for those seeking to improve their nutrient intake. With a focus on quality and efficacy, these supplements are designed to meet the needs of health-conscious consumers.
10X Health Optimize Methylated Multivitamin for Men & Women - 34 in 1 Formula with 800 mcg of Vitamin B12, Vitamin E, 5-MTHF, B Complex, NAC, Magnesium & Zinc Multivitamins - 90 Capsules
- Targeted Nutritional Support: 10x Optimize methylated multivitamins offer the ultimate multivitamin and mineral formula to address genetic deficits in your methylation pathway. This impacts your overall wellness and supports optimal health.
- Essential Methylated Nutrients: This includes crucial methylated vitamins like 5-MTHF (methylated folic acid), methylated B12, riboflavin (B2), and pyridoxine (B6). This multivitamin-methylated formula supports your body's natural methylation processes.
- Vital Minerals for Balance: Formulated with optimized minerals such as magnesium and zinc, 10X Optimize multivitamins for women and men help to maintain essential mineral balance and support the immune system, energy production, and cognitive function.
- Additional Methylation Support: Contains NAC (N-acetyl L-cysteine), a powerful amino acid known for its excellent support of the methylation pathway. NAC helps boost your body's ability to boost antioxidant levels and promote cellular health.
- Quality and Safety Focused: The 10X Optimize methylated multivitamin from 10X Health System is proudly made in the USA using premium, carefully sourced ingredients. Each batch undergoes rigorous quality and purity testing, ensuring your wellness.
$53.00
Methylated Multivitamin (Methylated and Activated Vitamins Only - Methylated B Complex with Trimethylglycine (TMG) and Methylfolate)(Non-GMO, Gluten Free MTHFR Supplement) 120 Capsules by Double Wood
- METHYLATED FORMS OF VITAMINS: Double Wood's Methylated Multivitamin contains only methylated / activated forms of vitamins that are already usable by the body and do not need to be further converted in order to be bioavailable
- METHYLATED B COMPLEX: Contains the Methylated / Activated Coenzyme form of Vitamin B2 (R-5-P), Vitamin B6 (P-5P) and Vitamin B12 (Methylcobalamin and Dibencozide)(Methyl B12)
- SIX TOTAL METHYLATED VITAMINS: Contains trimethylglycine and calcium L-5-methyltetrahydrofolate (MTHFR multivitamin) to help support healthy folic acid levels and control homocysteine levels in the body. It is important to use methylated folic acid since standard folic acid is inert in the body and cannot be processed further by many people
- CAN COMBINE WITH A NORMAL MULTIVITAMIN: Double Wood's Methylated Multivitamin can be combined with a regular multivitamin for those looking to also supplement with inactive vitamins or vitamins such as Magnesium and Vitamin D
- WE BOTTLE WELLNESS: At Double Wood we provide pure, potent supplements that deliver exceptional value, all backed by careful sourcing and rigorous third-party testing
$21.95
L Methyl Folate 15mg Plus Methyl B12 Cofactor – High Potency, Active 5-MTHF Form - Supports Mood, Methylation, Cognition – Bioactive Forms of Vitamin B9 & B12 (60 Capsules – 60 Servings)
- HIGH-POTENCY: Provides a high-potency serving of 15mg L-Methylfolate in the 5-MTHF calcium salt form. This bioactive form of folate is readily utilized by the body.
- VITAL METHYL B12 COFACTOR: Methylcobalamin B12 and Methylfolate have co-dependent relationships that work together in the body's methylation processes. Methylfolate cannot complete the methylation process and breakdown of homocysteine without Methyl B12.
- ACTIVE FORM OF FOLATE: Methylfolate is the most metabolically active and bloodstream-ready form of Folate or Folic Acid (vitamin B9). It is immediately absorbed into the bloodstream because it does not require processing or breakdown by the body. This is vital for those with methylation issues that cannot properly process folic acid.
- SUPPORTS BRAIN, MOOD & ENERGY HEALTH: Important for healthy neurotransmitter function linked to focus, energy, and a balanced mood.
- SUPPORTS CARDIOVASCULAR, NITRIC OXIDE & NERVE HEALTH: Helps maintain healthy homocysteine levels, promotes normal heart function, and supports nitric oxide production for overall circulatory and nerve well-being.
$21.97
Methyl Multi Without Iron Methylated Multivitamin for Men & Women, 120-Day Supply | Methyl B12 & Methylfolate (5-MTHF) for MTHFR Support | Pharma Grade Multivitamin & Multimineral For Health, 240 Caps
- 𝐄𝐋𝐄𝐕𝐀𝐓𝐄 𝐓𝐎𝐓𝐀𝐋 𝐖𝐄𝐋𝐋𝐍𝐄𝐒𝐒: Discussed on The Joe Rogan Experience with Gary Brecka, our Methyl Multi without Iron is a vegan-friendly, hypoallergenic, and meticulously-researched multivitamin and multimineral supplement made from high-quality ingredients with zero fillers. Our comprehensive formulation promotes healthy cognitive function and supports antioxidant protection and detoxication. Methyl Multi is the ultimate multivitamin to support total-body wellness and optimum vitality.
- 𝐎𝐏𝐓𝐈𝐌𝐀𝐋 𝐀𝐁𝐒𝐎𝐑𝐏𝐓𝐈𝐎𝐍: When supplementing, absorption is key! Methyl Multi without Iron is formulated with Quatrefolic Folate (5-MTHF), Albion TRAACS mineral chelates, and other micronutrients in their pre-methylated and coenzyme forms for optimal absorption and bioavailability, all together in patented EMBOCAPS AP60 acid resistant vegetable capsules designed for a guaranteed 60 minutes of acid-protection.
- 𝐂𝐎𝐌𝐏𝐋𝐄𝐓𝐄 𝐌𝐓𝐇𝐅𝐑 𝐒𝐔𝐏𝐏𝐎𝐑𝐓: Millions of Americans have MTHFR and/or COMT mutations, making it difficult for their bodies to process key vitamins like B12 and Folate. Methyl Multi without Iron contains pre-methylated forms of B12 and Folate for increased bioavailability, which can help to support healthy metabolism, energy release from food, detoxification, and nervous system function.
- 𝐍𝐄𝐖 𝐓𝐎 𝐌𝐄𝐓𝐇𝐘𝐋𝐀𝐓𝐈𝐎𝐍? For those extremely sensitive or new to methylated vitamins, we recommend gradually increasing the amount you are taking so your body can adapt. A small percentage of customers can experience a temporary detoxification / Herxheimer response. Symptoms may include: headache, lethargy, skin rash / hives, respiratory symptoms (cough, sore throat). These are temporary and a sign that the supplement is working. However if your body detoxes too quickly at one time it can overload your detox pathways! It’s imperative to lower the amount you are taking for a few days and work your way up slowly to the full dose “LOW & SLOW”
- 𝐍𝐎 𝐀𝐑𝐓𝐈𝐅𝐈𝐂𝐈𝐀𝐋 𝐈𝐍𝐆𝐑𝐄𝐃𝐈𝐄𝐍𝐓𝐒: Pure TheraPro Rx Methyl Multi without Iron contain no fillers such as rice flour, cornstarch, or wood pulp fibers. Our manufacturing facility adheres to strict NSF/cGMP guidelines. Consumer safety and satisfaction are our highest priority, which is why our products undergo rigorous third-party testing and screening to ensure product purity and potency.
$52.97
SALE
−$1.85
Igennus Super B-Complex Methylated B Vitamins, Sustained Release, Clean Label, MTHFR Supplement with Methylfolate & B12 Methylcobalamin, Vegan, Lab Verified, 60 Small Tablets
- METHYLATED B VITAMINS AND FOLATE that the body utilises immediately: bioavailable folate as methylfolate & methylcobalamin (Vit B12) - no poorly absorbed cyanocobalamin*
- HIGH STRENGTH, SUPER ABSORBABLE B complex vitamins including thiamine (B1), Riboflavin-5-phosphate (B2), Nicotinamide (flush free Niacin - B3), Calcium D-pantothenate (B5) & D-Biotin (B7)*
- SUSTAINED RELEASE technology gradually releases vitamins (important for optimising B12 levels), whilst twice daily dosing provides all-day nutrient coverage*
- INTENSIVE HEALTH SUPPORT for energy metabolism, the immune and hormonal systems, homocysteine regulation, nutrient metabolism, heart function and psychological function*
- PURE & CLEAN: vegan, non-GMO, hypoallergenic ingredients, no unpleasant fillers (silicon dioxide, magnesium stearate or titanium dioxide). Lab verified, USA & UK GMP manufactured. Small 9mm tablets
$13.10
Pure Methylated B Complex for Women & Men | 240 Capsules with High Absorption Vitamin C | 11-in-1 with Vitamins B12, Thiamin, Folate + Inositol, Choline & More | Only Active Ingredients | Filler Free
- Micro Ingredients offers Pure Methylated B Complex Vitamins. 11-in-1 support with fat-soluble vitamin C. A capsuled formula that features raw, active ingredients with no fillers.
- Each bottle contains 240 capsules. Offers vitamin C (ascorbyl palmitate + ascorbic acid), thiamin, riboflavin (R5P), niacin (niacinamide), B6 (P5P), folate, B12 (methylcobalamin), biotin, pantothenic acid, choline, and inositol per serving.
- An advanced B complex with vitamin C, choline, and inositol promotes various health benefits that target energy, cellular, heart, immune, and brain health.
- Enjoy only active ingredients that use high bioavailable methylated vitamins and easily absorbed fat-soluble vitamin C for enhanced antioxidant benefits.
- Premium non-GMO B complex supplements. Made without fillers, soy, dairy, gluten, fish, shellfish, peanuts, and tree nuts. Ingredients must pass our 3rd party lab tests to ensure a product that is safe, pure, and potent.
$24.99
SALE
−$2.99
Igennus Comprehensive Methylated Multivitamin for Men, Clean Label, Methylated Folate & B12, MTHFR, 22 Highly Bioavailable Nutrients, Sustained Release, Non-GMO, Halal, Third Party Tested, 60 Tablets
- METHYLATED & ACTIVE FORMS - each nutrient form has been carefully selected to optimize the journey from supplement to cell. Includes methylated B-vitamins, chelated minerals and gentle zinc (new label, same advanced formula, you may receive either label)*
- SLOW-RELEASE FORMULA: blood nutrient levels are optimized with bioactive vitamin forms & slow-release formula. Take 1 tablet twice per day as a split dose
- MULTIVITAMIN FOR MEN: 22 high-potency nutrients including bioactive B-complex, chelated minerals and antioxidant complex enhanced with lycopene; iron-free
- MORE OF WHAT YOU NEED, LESS OF WHAT YOU DON'T - our nutritionists have formulated a comprehensive multivitamin for men, topping up nutrients often lacking in everyday diets, without unnecessary extras*
- PURE & CLEAN: lab-verified ingredients; UK GMP manufactured; vegan; no silicon dioxide or magnesium stearate; fully recyclable packaging; easy-to-swallow oval tablets
$20.00
SALE
−$1.60
Igennus Methylated Women's Multivitamin, Methylated Folate for MTHFR, 21 Highly Bioavailable Nutrients, Clean Label & Sustained Release, with Iron, Non-GMO, Halal, 60 Vegan Tablets
- METHYLATED & ACTIVE FORMS each nutrient form has been carefully selected to optimize the journey from supplement to cell. Includes methylated B-vitamins, chelated minerals, gentle iron and zinc (new label, same advanced formula, you may receive either label)*
- PURE & CLEAN vegan, non-GMO, hypoallergenic & lab-verified ingredients with no unpleasant fillers (silicon dioxide, magnesium stearate or titanium dioxide). GMP manufactured in the UK
- HIGH POTENCY we have boosted levels of iron, B-vitamins, vitamin D and zinc in ratios that work in balance with the body. Provides enhanced support for energy, immunity, hormone balance and mood. Supplementing with iron may not be suitable for postmenopausal women*
- MORE OF WHAT YOU NEED, LESS OF WHAT YOU DON'T - our nutritionists have formulated a comprehensive multivitamin for women of menstruating age, topping up nutrients often lacking in everyday diets, without unnecessary extras*
- ALL-DAY COVERAGE this high-absorption formula is enhanced with sustained release delivery, optimizing blood nutrient levels for maximum health benefits and peace of mind. Take two, small tablets daily*
$17.35
Inessa Methylated Multivitamin for Men and Women - Advanced Natural Daily Mens Multivitamins with CoQ10 100mg, Vitamins D3, K2, A, B Complex Vitamins, Folic Acid & Zinc - 60 Vegan Tablets
- [Feel Like You, But Better] You want to thrive, not just survive. You want best, not just better, health. So meet the cutting-edge multivitamin supplement designed with your optimal wellness in mind. This magical multivitamin with K2 and vitamin D3 is productivity powerhouse that keeps you feeling fresh and focused, all-day-long.
- [Daily Wellness, Simplified] - Why take multiple supplements to get everything you need? This one-a-day wonder has 25 ingredients in highly bioavailable doses crammed into every dose. It’s one of the only multivitamins that works like an antioxidant complex, B-complex, CoQ10, vitamin D3 and vitamin K2 supplement in one.
- [Vegan Society Approved] Eating clean? We hear you. This women's and men’s vegan multivitamin is also allergen, gluten and dairy free. But don’t just take our word for it. We batch test our multivitamin supplement for purity and it contains no unnecessary additives, chemicals, flavorings or color.
- [Fights Fatigue] Micronutrient deficiencies can impact your vitality, and even healthy diets may not give you everything you need for boundless energy. But with relevant doses of CoQ10, B-complex vitamins, D3, iodine and more, this women's and men’s multivitamin will put the natural spring back into your step.
- [Nature's Nourishment] - Embrace a natural approach to wellness with our gluten-free, vegan multivitamin. Crafted for modern men like you, it champions your dietary choices while enriching your health journey. Make every day a step toward a healthier, happier you!
$39.99
Methylated B Complex with Methylfolate and B12 Methylcobalamin 1000 mcg - Methylated Multivitamin for Energy, Brain Function, and Wellness - Vitamin B Complex for Men & Women (90 Servings) (Pack of 1)
- This comprehensive Methylated B complex is for anyone looking for holistic support for their active lifestyle. It's a B complex vitamin for women imbued with high-quality vitamins your body can readily absorb.
- Each serving of our methylfolate vitamin b complex capsules has eight types of bioactive B vitamins including vitamin B1, B2, B3, B5, B6, B7 and vitamin B12 1000mcg—exactly the b12 vitamins methylcobalamin you need for a vibrant life.
- Our vitamin b1 b6 b12 complex has ingredients that may help with daily energy, brain power, and everyday nutritional support tailored especially for you. This vitamin b complex methylated also comes with niacin and vitamin B6.
- One methylcobalamin b12 supplement, multiple benefits. Our methylated formula for overall well-being has superior bioavailability and absorption. The result? Precise and effective nutritional support.
- Take 1 capsule of our b complex vitamins daily, early in the morning with 8oz of water and a meal. For best results, take at least 60 days. Our methylated vitamin B Complex supplement has 360mg per serving with no artificial flavors, preservatives, or fillers.
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