Heartburn medicine for immediate relief is essential for those who experience discomfort from acid reflux. In 2025, several over-the-counter options stand out for their effectiveness and rapid action. Antacids like Tums and Rolaids provide quick relief by neutralizing stomach acid, while H2 blockers such as Zantac and Pepcid offer longer-lasting effects. Proton pump inhibitors like Prilosec and Nexium are also popular for their ability to reduce acid production. Additionally, natural remedies like ginger and aloe vera juice are gaining traction for their soothing properties. Choosing the right heartburn medicine can make a significant difference in managing symptoms effectively.
SALE
−$4.96
Amazon Basic Care Omeprazole Delayed Release Tablets 20 mg, Treats Frequent Heartburn, Acid Reducer, Heartburn Medicine, 42 Count (Pack of 1) (Packaging may vary)
- ACTIVE INGREDIENT: The active ingredient in these delayed release tablets is omeprazole 20 mg, which works as an acid reducer to treat frequent heartburn. Compare to Prilosec OTC
- TREATS FREQUENT HEARTBURN: Amazon Basic Care Omeprazole Delayed Release Tablets 20 mg treat frequent heartburn that occurs 2 or more times a week
- ACID REDUCER: Amazon Basic Care Omeprazole Delayed Release Tablets 20 mg is a Proton Pump Inhibitor (PPI) that deactivates pumps in the stomach lining to inhibit acid production at the source.
- 14-DAY COURSE OF HEARTBURN TREATMENT: Taken once every 24 hours for 14 days, Amazon Basic Care Omeprazole Delayed Release Tablets 20 mg is not intended for immediate relief of heartburn and may take 1 to 4 days for full effect.
- HEARTBURN TIPS: Do not eat late at night or just before bedtime. Certain foods or drinks are more likely to cause heartburn, such as rich, spicy, fatty and fried foods, chocolate, caffeine, alcohol and even some fruits and vegetables.
$10.84
SALE
−$6.35
Gaviscon Extra Strength Cherry Chewable Tablet For Fast-Acting Heartburn Relief, 100 Count
- Gaviscon provides fast acting, long lasting heartburn relief and is an acid reflux remedy (when used as directed)
- Relieves heartburn, sour stomach, acid indigestion, and upset stomach associated with these symptoms
- Quickly neutralizes stomach acid and helps keep acid down for hours (when used as directed)
- Gaviscon is gastroenterologist recommended for heartburn and is available in both liquids and chewable tablets
- Gaviscon Extra Strength Tablet Antacid Cherry flavor contains the active ingredients aluminum hydroxide and magnesium carbonate
$9.64
Alka-Seltzer Heartburn+Gas ReliefChews, Fast Antacid + Antigas Relief from Heartburn, Bloating, and Pressure, Fast Acting, Tropical Flavored Heartburn Medicine, 180 Ct (Package May Vary)
- SUBSCRIBE AND SAVE: Save up to 15% when you subscribe and save with Alka Seltzer
- FAST, TASTY RELIEF: Feeling that second helping? Alka-Seltzer Heartburn+Gas ReliefChews offer antacid + antigas relief of heartburn, gas, and bloating that start working fast on contact
- HEARTBURN+GAS RELIEF: Our favorite meals can sometimes cause our not so favorite symptoms. These antacid tablets relieve heartburn, acid indigestion, sour stomach and upset stomach, as well as gas, bloating, pressure, and stuffed feeling
- RELIEF ALWAYS WITHIN REACH: Conveniently sized for a backpack, purse, gym bag, and more, these on-the-go antacid chews offer portable, powerful heartburn relief and gas relief
- RELIEF IS A BREEZE: Refreshing, tropical fruit flavored tablets provide heartburn and gas relief in non-chalky, non-gritty tablets. To use, adults and children 12+ simply take 1 to 2 chewable antacid + antigas tablets as symptoms occur
$26.66
Wonderbelly Antacid, Effective Heartburn and Instant Acid Indigestion Relief, Extra Strength Chewable Tablets, 1000 mg Calcium Carbonate, No Talc or Dye, Tropical Fruit, 60 Count
- SAME EFFECTIVENESS AS LEADING BRANDS – 1000mg Calcium Carbonate medicine relieves heartburn, acid reflux symptoms like indigestion, sour belly and upset stomach quickly with the same active ingredient dosage as leading brands
- MAXIMUM STRENGTH & INSTANT RELIEF – 3 fast acting chews per packet offer soothing relief with a great taste, no unnecessary ingredients and sustainable packaging
- CLEAN INGREDIENTS - We use active pharmaceutical ingredients to formulate effective medicine that is NON-GMO, vegan, and free of artificial dyes, including Red Dye 3, artificial sweeteners, talc, titanium dioxide, parabens, gluten, and dairy
- DELICIOUS FLAVOR – The Tropical Fruit flavor tastes like a bright, refreshing medley of mango, pineapple, and oranges. With flavor so crisp, you’ll feel like you’re on a beach in the Caribbean
- HOW TO USE – Chew 2-3 tablets for Women, Men, Adults and Children 12 years or older as symptoms occur. If pregnant or breastfeeding ask a health professional before use
$11.99
SALE
−$1.01
Chattem Inc. Rolaids Ultra Strength Antacid, 72 Chewable Tablets, Assorted Fruit, Ultra Strength Heartburn Relief
- CONTAINS: One (1) 72-count bottle of Rolaids Ultra Strength Antacid Chewable Tablets, Assorted Fruit flavors
- OLAIDS ULTIMATE ACID-NEUTRALIZING HEARTBURN RELIEF: Rolaids Ultra Strength antacid tablets neutralize more than 100 times their own weight in stomach acid*
- GOES TO WORK INSTANTLY: Chewable antacid tablets with calcium carbonate and magnesium hydroxide start to work immediately to help relieve heartburn, acid indigestion, and sour stomach
- CONVENIENT: Chew 2-3 tablets as symptoms occur or as directed by a doctor; do not take more than 7 tablets in 24 hours; do not use the maximum dosage for more than 2 weeks
- ASSORTED FRUIT FLAVOR: This heartburn relief tablet comes in an assorted fruit flavor
$4.98
Amazon Basic Care Dual Action Complete, Chewable Acid Reducer Plus Antacid Tablets, Berry Flavor, Heartburn Medicine, Acid Indigestion Relief, 50 Count
- ACTIVE INGREDIENTS: This product contains famotidine 10 mg (an acid reducer), calcium carbonate 800 mg and magnesium hydroxide 165 mg (both of which are antacids). Compare to the active ingredients in Pepcid Complete
- EFFECTIVE: Acid Reducers like Dual Action Complete, Famotidine 10 mg/Calcium Carbonate 800 mg/Magnesium Hydroxide 165 mg Tablets (Chewable) can relieve heartburn due to acid indigestion and sour stomach
- HEARTBURN occurs when stomach acid backs up into the esophagus—the muscular tube that carries food and liquids from the mouth to the stomach. A heartburn medicine like Dual Action Complete helps provide heartburn relief.
- MANAGING HEARTBURN: In addition to using Dual Action Complete or another heartburn medicine, these tips can also help with heartburn relief: do not lie flat or bend over after eating; do not eat before bedtime; eat slowly and avoid big meals.
- TYPES OF HEARTBURN MEDICINE: Antacid tablets help to treat mild heartburn (indigestion). Proton pump inhibitors (PPIs) are used to treat frequent heartburn. H2-Blockers like Dual Action Complete work as acid reducers to help relieve heartburn.
$14.75
SALE
−$2.46
Boiron Acidil for Relief of Acid Reflux, Heartburn, Indigestion, and Upset Stomach - 60 Count
- PLANT-POWERED MULTI-SYMPTOM HEARTBURN AND ACID INDIGESTION RELIEF: Acidil Melaway tablets contain plant-based active ingredients to help relieve occasional heartburn, acid indigestion, bloating, and upset stomach.*
- MELTAWAY TABLETS, NO WATER NEEDED: These easy-to-take unflavored meltaway tablets dissolve in your mouth without the need for water, and can be taken on a full or empty stomach. Recommended for adults and children ages 12 and older.
- HELP YOUR BODY THE NATURAL WAY: Acidil is a homeopathic heartburn medicine that has no known interactions with other medications, herbs, or supplements. It’s also gluten-free with no artificial sweeteners, flavors, colors, or preservatives.
- A TRUSTED BRAND: With more than 90 years of expertise, Boiron medicines are manufactured to meet the highest standards of cGMP and HPUS for purity and quality.
- BUY WITH YOUR HSA/FSA: Many of your favorite Boiron medicines are HSA & FSA eligible.
$9.29
Amazon Basic Care Omeprazole and Sodium Bicarbonate Capsules, 20 mg/1100 mg, 24-Hour Frequent Heartburn Medicine, Acid Reducer Pills, 42 Count
- ACTIVE INGREDIENTS: The two active ingredients are omeprazole 20 mg, an acid reducer, and sodium bicarbonate 1100 mg, which allows absorption of this omeprazole product; compare to the active ingredients of Zegerid OTC
- ACID REDUCER: When taken as directed, this heartburn medicine works to reduce heartburn by deactivating acid-producing pumps in the stomach lining to inhibit acid production at the source
- 14-DAY TREATMENT: Omeprazole and Sodium Bicarbonate Capsules, 20 mg/1100 mg is not a heartburn medicine intended for immediate heartburn relief, and may take 1 to 4 days for full effect; fight frequent heartburn with this gluten-free omeprazole option
- TREATS FREQUENT HEARTBURN: This product is for treating frequent heartburn that occurs 2 or more days per week; stops acid production at the source -- the acid pump that produces stomach acid
- HEARTBURN TRIGGERS: Certain foods or drinks are more likely to cause heartburn, such as rich, spicy, fatty and fried foods, chocolate, caffeine, alcohol and even some fruits and vegetables; to avoid heartburn, eat slowly and do not eat big meals
$15.74
Zegerid OTC, Omeprazole 20mg and Sodium Bicarbonate, Heartburn Medicine, Acid Reducer, PPI, 24hr All Day Protection, 1 Pack 42 Capsules
- CLINICALLY PROVEN - Zegerid OTC is clinically proven to treat frequent heartburn
- THE ONLY OTC PPI WITH TWO ACTIVE INGREDIENTS: Omeprazole provides powerful heartburn relief. Plus, Sodium Bicarbonate ensures your body can absorb it properly.
- JUST ONE PILL A DAY - Zegerid OTC proton pump inhibitor medication treats frequent heartburn.
- 24 HOURS / ZERO HEARTBURN
- Use as directed for 14 days for treating frequent heartburn. As with all PPIs, may take 1-4 days for full effect, although some people might get complete relief within 24 hours.
$22.98
Acid Reflux Complete 8oz - Natural Organic Liquid Heartburn, GERD, & Amish Reflux Relief Remedy & Medicine
- MADE WITH ORGANIC and KOSHER INGREDIENTS: The whole Acid Reflux Treatment is Certified USDA Organic and OU Kosher. Ingredients you can count on being healthy for you.
- TASTES GREAT & EASY TO TAKE! As a liquid, this time tested Organic Amish Acid Reflux Remedy is absorbed far better than any pill or capsule would be. It is an all Natural and healthy medicine, with ingredients like Aloe, Ginger, Garlic, & Vanilla.
- GET RESULTS: Stops Acid Reflux, Heartburn, GERD, and Prevents Acid Indigestion and Sour Stomach.
- PILLOW OR WEDGE NOT REQUIRED! Acid Reflux Complete absorbs quicker at a higher percentage because it is a liquid.
- MADE IN THE USA: Complete Natural Products formulates, manufactures, and bottles everything! You are getting an amazing Heartburn Remedy straight from the source.
$12.95
Last update on 2025-05-03 / Affiliate links / Images from Amazon Product Advertising API