Head cold medicine is essential for alleviating the discomfort associated with seasonal colds, and in 2025, there are numerous effective options available. From decongestants to antihistamines, these medications can help relieve symptoms such as nasal congestion, sneezing, and headaches. Some of the top choices include popular brands known for their fast-acting relief and soothing formulations. Whether you prefer liquid, tablet, or nasal spray forms, finding the right head cold medicine can make a significant difference in your recovery.
SALE
−$2.20
Sudafed PE Head Congestion + Mucus Tablets for Sinus Pressure, Pain & Congestion, 24 ct
- 24-count box of Sudafed PE Head Congestion + Mucus Tablets to provide non-drowsy relief from sinus pain and pressure, nasal & chest congestion, and excess mucus
- Sinus relief medicine contains 5 mg of phenylephrine HCl, a decongestant, for congestion relief and 325 mg of acetaminophen for pain and fever reduction. Also has 200 mg of guaifenesin, an expectorant, for mucus reduction
- Head congestion tablets temporary relieves symptoms associated with hay fever, upper respiratory allergies, and the common cold
- Non-drowsy decongestant tablets provide relief of sinus pressure, headaches, nasal and chest congestion, excess mucus, and minor aches and pains
- Head congestion relief medicine also helps loosen mucus to clear bronchial passageways and make coughs more productive. Get powerful head congestion relief from the pharmacist recommended brand among oral OTC decongestants.
$8.47
SALE
−$0.92
Tylenol Cold + Head Congestion Severe Medicine Caplets for Fever, Pain, and Congestion, Acetaminophen Pain Reliever, Fever Reducer, 24 Count
- 24-count bottle of Tylenol Cold Head Congestion Severe Caplets provide effective relief of multiple symptoms due to the flu and common cold
- This severe cold & flu medicine helps relieve headache, minor aches and pains, sore throat, nasal congestion, and sinus congestion and pressure. It also temporarily reduces fever and helps to loosen phlegm to make coughs more productive.
- Each caplet contains 325 mg of acetaminophen to help reduce fever and relieve minor aches and pains, as well as 5 mg of the nasal decongestant phenylephrine HCl to help relieve congestion
- Each caplet also contains 200 mg of the expectorant guaifenesin to help loosen phlegm (mucus). Tylenol Cold Head Congestion Severe Caplets do not contain dextromethorphan HBr.
- From the #1 doctor-recommended pain relief brand, this cold & flu medicine is suitable for use by adults and children 12 years and older for powerful multi-symptom relief
$7.57
SALE
−$1.19
Boiron ColdCalm Tablets for Relief of Common Cold Symptoms Such as Sneezing, Runny Nose, Sore Throat, and Nasal Congestion - Non-Drowsy - 60 Count
- MULTI-SYMPTOM COLD RELIEF: ColdCalm Tablets relieve common cold symptoms, including sneezing, runny nose, nasal congestion, and minor sore throat, at every stage of the cold.* Non-drowsy relief with no known drug interactions for ages 4 and up.
- MELTAWAY CONVENIENCE: ColdCalm Tablets dissolve easily in the mouth without the need for water, chewing or swallowing, so you can act fast against cold symptoms anywhere, anytime.
- HELP YOUR BODY THE NATURAL WAY: This homeopathic cold medicine is non-drowsy and non-habit forming and can be taken day or night. It’s also gluten-free and contains no artificial sweeteners, flavors, colors, or preservatives.
- A TRUSTED BRAND: With more than 90 years of expertise, Boiron medicines are manufactured to meet the highest standards of cGMP and HPUS for purity and quality.
- BUY WITH YOUR HSA/FSA: Many of your favorite Boiron medicines are now eligible for reimbursement. Look for our logo designating products that can be paid for with your Health Savings Account or Flexible Savings Account.
$9.99
SALE
−$3.00
Tylenol Cold + Flu Severe Medicine Caplets for Fever, Pain, Cough & Congestion, 24 ct.
- 24-count of Tylenol Cold + Flu Severe Pain Reliever & Fever Reducer Medicine Caplets provide effective relief of multiple symptoms due to the flu and common cold
- This severe cold & flu medicine helps relieve fever, headache, minor aches and pains, sore throat, nasal congestion, and cough. It also helps loosen phlegm (mucus) and thin bronchial secretions to make coughs more productive.
- Each caplet contains 325 mg of acetaminophen to help reduce fever and relieve minor aches & pains, as well as 10 mg of the cough suppressant dextromethorphan HBr to help quiet coughs
- Each caplet also contains 5 mg of the nasal decongestant phenylephrine HCl to help relieve congestion and 200 mg of the expectorant guaifenesin to help loosen phlegm (mucus) and make coughs more productive
- From the doctor-recommended pain relief brand, this cold & flu medicine is suitable for use by adults and children 12 years and older for powerful multi-symptom relief
$7.67
Vicks Sinex SEVERE LiquiCaps, All-In-One Sinus Relief, Non-Drowsy, Nasal Decongestant, Maximum Strength Relief of Sinus Headache, Pain, Pressure, & Congestion, 24 LiquiCaps
- Experience fast, powerful relief from nasal congestion, sinus pressure, sinus headache, and sinus pain!
- Best suited to treat sinus symptoms caused by the common cold, hay fever, or other upper respiratory allergies because it reduces pressure in the sinuses and relieves sinus pain!
- The powerful, non-drowsy nasal decongestant medicine and pain reliever help to provide all in one relief for your sinus symptoms!
- HSA and FSA eligible, Check with your provider for more details
- This product is not formulated with an antihistimine allergy medicine and is not intended to treat runny nose, itchy & watery eyes, or sneezing
$9.25
SALE
−$2.49
Sudafed PE Sinus Congestion Day + Night Maximum Strength Decongestant & Antihistamine Tablets with Phenylephrine HCl & Diphenhydramine HCl, Helps Nasal & Sinus Pressure & Congestion, 20 ct
- 20-count of Sudafed PE Sinus Congestion Day + Night Maximum Strength Decongestant Medicine Tablets to temporarily relieve sinus pressure and sinus congestion for both day and night
- Each multi-pack contains 20 tablets of nasal decongestant, with 12 Daytime and 8 Nighttime tablets for powerful symptom relief throughout the day and while you sleep
- Each daytime and nighttime dose contains 10 milligrams of the nasal decongestant phenylephrine HCl per tablet and each nighttime dose also contains 25 milligrams per tablet of the antihistamine diphenhydramine HCl
- Both formulas help relieve sinus pressure and sinus congestion, and nasal congestion due to the common cold, hay fever, or upper respiratory allergies. Nighttime tablets also relieve sneezing, runny nose, itchy, watery eyes and itchy throat or nose
- From the #1 pharmacist recommended brand among oral OTC decongestants, this maximum-strength formula can be used by adults and children 12 years and older for powerful symptom relief
$8.18
SALE
−$2.52
Mucinex Fast-Max Cold and Flu & Nightshift Severe Cold and Flu Medicine for Adults, Over-the-Counter Medication Combo Pack for Sore Throat Relief, Decongestant, Cough & Cold Medicines, 2 x 6 Fl Oz
- COUGH COLD AND FLU MEDICINES FOR ADULTS: This combo pack of Maximum Strength Mucinex Fast-Max Cold & Flu and Nightshift Severe Cold & Flu provides powerful multi-symptom cold and flu relief for your worst cold and flu symptoms
- SORE THROAT RELIEF: Both liquids contain Acetaminophen, which helps reduce fever and relieves sore throat, headache, and body pain
- COUGH MEDICINE FOR ADULTS: Both liquids contain Dextromethorphan HBr, which helps suppress and quiet cough
- CHEST CONGESTION RELIEF: Daytime liquid contains Guaifenesin, an expectorant, which helps relieve chest congestion and thins and loosens mucus
- NASAL DECONGESTANT: Both liquids contain Phenylephrine HCl, a nasal decongestant, which helps relieve stuffy nose, sinus pressure, & nasal congestion
$19.97
SALE
−$2.70
Advil Sinus Congestion and Pain, Sinus Relief Medicine, Pain Reliever and Fever Reducer with Ibuprofen and Phenylephrine HCl - 10 Coated Tablets
- One package of 10 coated tablets of Advil Sinus Congestion and Pain, Sinus Relief Medicine, Pain Reliever and Fever Reducer with Ibuprofen and Phenylephrine HCl
- Advil ibuprofen 200mg pain medicine for adults temporarily relieves fever, minor body aches and headache
- Phenylephrine HCl 10 mg tablets provide sinus pressure relief, nasal congestion relief and nasal swelling relief
- Coated tablets are easily portable, so you can have Advil congestion relief ready whenever you need it
- Sinus congestion medicine for adults and children 12 years and older - the perfect addition to your college dorm room essentials
$3.79
SALE
−$5.68
Tylenol Cold + Flu Severe Daytime & Nighttime Liquid Cough Medicine with Acetaminophen Pain Reliever & Fever Reducer, Nasal Decongestant & Antihistamine, Value Pack, 2 ct. of 8 fl. oz
- Value pack of Tylenol Cold + Flu + Cough Severe Liquid Medicine containing one 8-fluid ounce bottle of non-drowsy daytime relief medicine and one 8-fluid ounce bottle of nighttime relief medicine
- The daytime flu relief for adults features a powerful non-drowsy formula to keep you going through waking hours with a warming honey lemon flavor. The nighttime liquid medicine relieves symptoms to help you sleep and comes in a soothing berry flavor.
- The liquid medicines both provide temporary relief of cold & flu symptoms including fever, cough, nasal & chest congestion, head & body aches & sore throat. They also aid in loosening mucus & thinning bronchial secretions for more productive coughs
- Formulated with acetaminophen for pain relief & fever reduction, phenylephrine HCl nasal decongestant, guaifenesin as an expectorant & dextromethorphan HBr cough suppressant. The nighttime formula also contains doxylamine succinate, an antihistamine
- Temporarily relieve multiple symptoms both day and night with these powerful severe cold, cough, and flu medicines for adults
$13.00
SALE
−$0.60
Zicam Cold Remedy Zinc Medicated Fruit Drops, Assorted Flavors, Homeopathic, Cold Shortening Medicine, Shortens Cold Duration, 25 Count
- Zicam for Shorter Colds: Zicam homeopathic cold remedy is meant to be used in the beginning of a cold; Try Zicam the next time you feel the first sniffle, sneeze or cough of an oncoming cold; Satisfaction guaranteed
$10.39
Last update on 2025-05-03 / Affiliate links / Images from Amazon Product Advertising API