Flea treatment for dogs is essential for maintaining your pet's health and comfort. In 2025, the market offers a variety of effective solutions, ranging from topical treatments and oral medications to collars and natural remedies. Each product varies in its active ingredients and method of application, ensuring that pet owners can find the right fit for their furry friends. With advancements in veterinary science, these treatments not only eliminate existing fleas but also provide long-lasting protection against future infestations. Choosing the best flea treatment for your dog can significantly enhance their quality of life and prevent the discomfort associated with flea bites.
SALE
−$5.01
FRONTLINE Plus Flea and Tick Treatment for Large Dogs Up to 45 to 88 lbs. 3 Treatments
- Keep your dog protected from fleas & ticks all month long with FRONTLINE Plus for Dogs a fast-acting, waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease
- Break the flea life cycle with FRONTLINE Plus, specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control
- Trusted by pet owners for over 20 years, FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply with one monthly dose providing protection from fleas & ticks for a full 30 days
- FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over, so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products
- Treat all dogs or cats in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations
$39.98
K9 Advantix II XL Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs Over 55 lbs. | 2-Mo Supply
- K9 Advantix II Extra Large Dog 30-day treatment & prevention protects dogs over 55 lbs. from fleas, ticks, mosquitoes, biting flies and lice
- Kills fleas within 12 hours of application
- Vet-recommended formula kills & repels on contact so fleas don’t have to bite your dog to die
- Easy-to-apply topical treatment is fragrance-free and waterproof after 24 hours
- No prescription needed
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SALE
−$4.06
PetArmor Plus Flea and Tick Prevention for Dogs, Dog Flea and Tick Treatment, 3 Doses, Waterproof Topical, Fast Acting, Small Dogs (5-22 lbs)
- EFFECTIVE, WATERPROOF FLEA TREATMENT FOR DOGS: PetArmor Plus is a waterproof, flea & tick topical prevention for dogs that kills fleas, flea eggs, flea larvae, ticks, and chewing lice for up to 30 days after application.
- TRUSTED, VET QUALITY FORMULA: Containing fipronil and (S)-methoprene, the same active ingredients as FRONTLINE Plus for Dogs. PetArmor Plus for Dogs has a powerful formula that starts to kill fleas within 24 hours.
- BREAK THE FLEA CYCLE: Unlike other flea and tick treatments that may temporarily suppress flea activity, PETARMOR Plus Dog Flea Treatment works by effectively breaking the flea life cycle. Kill flea eggs and larvae to prevent re-infestation.
- FAST ACTNG LONG-LASTING FLEA AND TICK PROTECTION: One application of PetArmor Plus lasts up to 30 days nose to tail. A 6-dose package lasts up to six months.
- EASY-TO-USE, LONG-LASTING: PetArmor Plus flea and tick treatment comes with three (3) waterproof topical applications that provides your pet flea protection and control for three (3) months.
$24.93
Amazon Basics Flea and Tick Topical Treatment for Large Dogs (45-88 pounds), Unscented, 3 Count (Previously Solimo)
- FAST-ACTING RELIEF: Begin eliminating fleas and ticks within 24 hours of application, providing relief for your large dog
- LONG-LASTING PROTECTION: This flea treatment for dogs offers up to 30 days of coverage, protecting your pet from harmful pests
- INFESTATION CONTROL: Active ingredients in this dog flea medicine target eggs, larvae, adult fleas, as well as mosquitoes, lice, and flies
- FOR LARGE DOGS: Specifically designed for dogs weighing 45-88 pounds, providing a precise and effective flea and tick solution
- FORMULA: This topical flea treatment for dogs contains Fipronil and (s)-methoprene
$19.21
Seresto Large Dog Vet-Recommended Flea & Tick Treatment & Prevention Collar for Dogs Over 18 lbs. | 8 Months Protection
- Vet-recommended, premium flea & tick protection for dogs & puppies without the price tag
- Long-lasting flea and tick collar kills & repels fleas for 8 continuous months
- Seresto is the #1 veterinarian recommended flea & tick collar*
- Starts working within 24 hours to kill & repel fleas by contact so pests don’t have to bite your dog to die
- Hassle-free, non-greasy, easy-to-use flea & tick protection
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SALE
−$5.01
FRONTLINE Plus Flea and Tick Treatment for Small Dogs Upto 5 to 22 lbs. 3 Treatments
- Keep your dog protected from fleas & ticks all month long with FRONTLINE Plus for Dogs a fast-acting, waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease
- Break the flea life cycle with FRONTLINE Plus, specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control
- Trusted by pet owners for over 20 years, FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply with one monthly dose providing protection from fleas & ticks for a full 30 days
- FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over, so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products
- Treat all dogs or cats in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations
$39.98
K9 Advantix II Large Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 21-55 lbs. | 1-Mo Supply
- K9 Advantix II Large Dog 30-day treatment & prevention protects dogs 21-55 lbs. from fleas, ticks, mosquitoes, biting flies and lice
- Kills fleas within 12 hours of application
- Vet-recommended formula kills & repels on contact so fleas don’t have to bite your dog to die
- Easy-to-apply topical treatment is fragrance-free and waterproof after 24 hours
- No prescription needed
$18.98
Amazon Brand - Solimo for Dogs Medium Dog (23-44 pounds) Flea and Tick Treatment, 6 Doses
- Same product, new look – This product is identical in manufacturing and formulation as the Solimo brand
- One 6 dose pack of Amazon Basics Flea and Tick Topical Treatment for Medium Dogs (23 - 44 pounds), 6 Count (Previously Solimo)
- Amazon Basics Flea & Tick starts eliminating fleas and ticks within 24 hours of treatment
- Active ingredients Fipronil and (s)-methoprene prevent flea infestations by killing flea eggs, flea larvae, mosquitos, biting flies and chewing lice
- One application provides up to 30 days of protection
$27.95
SALE
−$9.00
FRONTLINE Plus Flea and Tick Treatment for Medium Dogs Up to 23 to 44 lbs. 3 Treatments
- Keep your dog protected from fleas & ticks all month long with FRONTLINE Plus for Dogs a fast-acting, waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease
- Break the flea life cycle with FRONTLINE Plus, specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control
- Trusted by pet owners for over 20 years, FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply with one monthly dose providing protection from fleas & ticks for a full 30 days
- FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over, so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products
- Treat all dogs or cats in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations
$35.99
Capstar(nitenpyram) for Dogs Fast-Acting Oral Flea Treatment for Dogs 2-25 lbs, Vet-Recommended Medication Tablets Start Killing in 30 Minutes, 6 Doses
- Fast-Acting Flea Treatment: CAPSTAR (nitenpyram) starts killing adult fleas in just 30 minutes
- Tackle Flea Infestations Fast: With one dose of CAPSTAR, you can watch the dead fleas fall off your pet
- Treat Reinfestations Fast: If your pet gets reinfested with fleas, simply give another dose as often as once a day
- No Prescription Needed: Fast, effective flea treatment for dogs that's available over the counter
- Intended Use: CAPSTAR Oral Flea Treatment for Small Dogs (57 mg) is safe for dogs and puppies 4 weeks and older that weigh 2-25 pounds
$39.98
Last update on 2025-05-02 / Affiliate links / Images from Amazon Product Advertising API