Eye drops for severe dry eyes are essential for providing relief and restoring moisture to the eyes. In 2025, the market offers a variety of effective options designed to combat the discomfort associated with this condition. From preservative-free formulations to those enriched with hyaluronic acid, these eye drops cater to different needs and preferences. Users can find products that not only alleviate dryness but also promote long-lasting hydration and comfort. Whether you suffer from chronic dry eyes or occasional discomfort, selecting the right eye drops can significantly enhance your quality of life.
Optase Dry Eye Intense Drops - Preservative Free Eye Drops for Long Lasting Relief - Artificial Tears to Relieve Severe Dry Eye Symptoms - Multidose Bottle - Step 3 Hydrate - .33 fl oz, 300 Doses
- MOISTURIZE AND PROTECT: Made of glycerin and quality ingredients, Optase Dry Eye Intense Drops mix with the natural oils needed to protect your tears and hydrate your eyes to improve tear quality
- PRESERVATIVE FREE: Optase Intense Eye Drops is the only product of its kind to provide a preservative free combination of ingredients designed to treat dry eye patients in a unique multi-dose bottle
- MODERATE TO SEVERE DRY EYE RELIEF: The long lasting formulation of Optase Intense provides comfort for dry eye and post operative patients. And it is contact lens safe, providing relief when needed
- ADVANCED BOTTLE TECHNOLOGY: A convenient multi-use drop bottle with advanced technology maintains sterility over 3 months without preservatives. Avoid the hassle of individual vials while on the go
- COMPLETE DOCTOR RECOMMENDED EYE CARE RELIEF: OPTASE is the expert recommended 3-step regimen to help tackle the cause and symptoms of Dry Eyes, Blepharitis and Meibomian Gland Dysfunction (MGD)
$23.98
SALE
−$1.73
Blink Eye Drops for Dry Eyes, Triple Care Lubricant Eye Drops, Instantly Soothing, Moisturizing & Extra Long-Lasting Hydrating Eye Care for Moderate to Severe Dry Eye Symptom Relief, 0.34 fl oz
- Relief with every Blink: Experience extended dry eye symptom relief with Blink Triple Care Lubricating Eye Drops. This 3-in-1 formula instantly soothes, gives extra long-lasting hydration, and seals in moisture.
- Dry Eye Lubricant: Discover what makes Blink Triple Care Lubricating Eye Drops different from other eye drops. Our drops for dry eyes have a dual-action moisture seal to lock in moisture for instant, long-lasting relief.
- Long-Lasting Hydration: Blink Triple Care Lubricating Eye Drops are formulated with hyaluronate - also found in your eyes - to boost hydration. Hydrate like your tears for extra long-lasting comfort
- Reduce Everyday Discomfort: These dops for dry eyes deliver extended relief for moderate to severe dry eye symptoms
- Trusted Brand: Blink has a range of products to meet your eye and contact lens care needs, from drops for dry eyes to lock in moisture, to preservative-free formulas; and contact lens drops to keep your contacts clean and hydrated.
$13.26
Systane Ultra Lubricant Eye Drops, Artificial Tears for Dry Eye, Twin Pack, 10-mL Each
- #1 Dr Recommended Brand of Artificial Tears*, packaging may vary
- Extended Protection
- Fast Long-Lasting Dry Eye Symptom Relief.Store at room temperature
- Reduces both the signs and symptoms of dry eye
- Quickly soothe irritated eyes wherever you are
$16.93
SALE
−$10.51
TheraTears Extra Dry Eye Therapy Lubricating Eye Drops for Dry Eyes, 0.5 fl oz Bottle, 2 Count(Pack of 1)
- Get up to 12 Hours of Hydrating Comfort; TheraTears EXTRA Dry Eye Therapy Lubricant Eye Drops provide EXTRAordinary relief for dry eyes
- Discover TheraTears eye drop; one-of-a-kind silky hydration for dry eyes
- Lubricating eye drops for extra dry eyes rehydrate; protect against further irritation and support a natural tear pH level
- TheraTears Extra Dry Eye lubricating eye drops contain the 5 vital electrolytes found in natural tears
- TheraTears corrects the salt imbalance that can cause dry eye symptoms
$11.48
iVIZIA Lubricant Eye Gel for Severe and Nighttime Dry Eye Relief, Preservative-Free, Moisturizing, 30 Sterile Single-Use Vials Packaging May Vary
- Your Dry Eyes Deserve Better: Thicker formula for overnight use, our gel provides more lubrication and moisture than our daytime formula and is ideal to relieve severe dry eye symptoms.
- Unique Formulation: Hydrating polymers form a protective matrix, moisturizing Hyaluronic Acid holds up to 1000x its weight in moisture, and Trehalose (synthetic ingredient also found in desert plants).
- Free of Irritating Preservatives: Sterile, preservative-free, and can be used before or after eye surgery.
- Sterile Single-Use Vials: iVIZIA Lubricant Eye Gel is offered in preservative-free sterile, single-use vials that are convenient and easy to use for severe dry eye or nighttime use.
- iVIZIA – We See a Better Way: for healthy, comfortable eyelids
$19.79
SALE
−$3.00
Blink GelTears Eye Drops for Dry Eyes, Gel Lubricating Eye Drops, Instantly Soothing, Moisturizing & Extra Long-Lasting Hydrating Eye Care for Moderate to Severe Dry Eye Symptom Relief, 0.34 fl oz
- Relief with Every Blink: Experience immediate and long-lasting dry eye symptom relief with Blink GelTears eye drops for dry eyes. This thicker, more viscous lubricating formula is for enhanced comfort and great for daytime and nighttime use
- Hydration Boost with Hyaluronate: Our gel lubricating eye drops for dry eyes instantly soothe and comfort. It contains our highest level of hyaluronate to provide longer lasting relief for moderate to severe dry eye symptoms
- Day & Night Relief: Blink eye drops are formulated for daytime and nighttime use and provides superior end-of-day comfort (in an Ocular Lubricant questionnaire, comfort ratings were statistically significantly higher for Blink GelTears vs. Allergan’s Refresh Optive Liquid Gel after 7 days and 30 days).
- Reduce Everyday Discomfort: These drops are an extra moisturizing gel for enhanced comfort. Work with every blink to restore your tears' natural balance and maximize hydration
- Trusted Brand: Blink has a range of products to meet your eye and contact lens care needs, from drops for dry eyes to lock in moisture, to preservative-free formulas; and contact lens drops to keep your contacts clean and hydrated.
$9.99
SALE
−$4.00
Refresh Optive MEGA-3 Lubricant Eye Drops Preservative-Free Artificial Tears, 0.01 fl oz (0.4 mL), 30 Single-Use Containers
- FAST-ACTING: Rapid relief to comfort dry, irritated eyes
- LASTING RELIEF: Soothes and prevents further irritation
- TRIPLE-ACTION FORMULA: Lubricates, hydrates, and protects tears from evaporating
- PRESERVATIVE-FREE: Enhanced with antioxidants and plant-based Flaxseed Oil (inactive ingredients) which contains omega-3s
- ADVANCED HYDRATION: Innovated with patented HydroCell technology that enables rehydration
$17.99
SALE
−$1.01
Systane Ultra Lubricant Eye Drops,0.14 Fl Oz (Pack of 1)
- Dr Recommended Brand of Artificial Tears
- Extended Protection
- Fast Long-Lasting Dry Eye Symptom Relief
- Reduces both the signs and symptoms of dry eye
- Quickly soothe irritated eyes wherever you are
$5.48
Systane Nighttime Lubricant Eye Ointment 3.5g Tube
- #1 Dr Recommended Brand of Artificial Tears*
- Provides nighttime relief of dry eye symptoms
- Ointment soothes and protects against dry, irritated eyes
- Forms long-lasting, protective layer on eyes while you sleep
- Safe, preservative-free formula
$14.29
Last update on 2025-05-03 / Affiliate links / Images from Amazon Product Advertising API