DAO enzyme supplements are gaining popularity for their potential to support individuals with histamine intolerance. In 2025, the market offers a variety of high-quality options that can help manage symptoms effectively. These supplements are formulated to enhance the body's ability to break down histamine, providing relief from discomfort associated with food sensitivities. With numerous brands and formulations available, it's essential to choose the right one that suits your needs. Here are the top 10 DAO enzyme supplements to consider for optimal health and well-being.
NATURDAO - 1,000,000 HDU - DAO Enzyme Supplement - Histamine Block - Diamine Oxidase - Food Intolerance - 60 Tablets
- ✔ GREATEST ENZYMATIC ACTIVITY ON THE MARKET with 1,000,000 HDUs / 32,1mg of vegetable protein, it is the most powerful DAO enzyme you can get to reinforce your digestive system.
- ✔ BEST NATURAL CHOICE if you are going to take it for a long period of time along with your diet. It is suitable for vegans.
- ✔ FAST AVAILABILITY TABLETS IN HUMAN INTESTINE tested by radiological test.
- ✔ This product contains nothing other than what is labeled. AVOID if allergic to any of the following ingredients: Cellulose (vegetable source), LEGUMACTIVE (Peas* Pisum Sativum, Lentils* Lens Culinaris), Hydroxypropylcellulose (vegetable source), Stearic Acid (vegetable source) and Silicon Dioxide (mineral). No food colours or genetically modified organisms.
- ✔ REFUND POLICY · Your well-being is our priority at NaturDao. To ensure utmost hygiene and safety, we don't accept returns. Unsatisfied with NaturDao? Reach out to us at naturdao.com with your order # for a hassle-free refund.
$39.90
Ancestral Supplements Grass Fed Beef Kidney Supplement, 3000mg, DAO Enzyme Supplement, Kidney Support for Urinary and Histamine Health, Selenium, B12, Non GMO, 180 Capsules
- TIME-HONORED KIDNEY SUPPLEMENTS: Grounded in the traditional wisdom of ancient practices, our kidney organ meat supplements are rich in kidney-specific proteins, peptides, enzymes and cofactors that support overall kidney health.
- DAO SUPPLEMENTS: Ancestral Supplements' Kidney Health Capsules include naturally occurring diamine oxidase (DAO), as well as B12 and Selenium to support healthy histamine levels in the body.
- WHOLE FOOD KIDNEY SUPPORT SUPPLEMENT: Our freeze-dried beef kidney health supplement offers nourishment that only whole foods can provide to promote urinary health and cleansing.
- NEW ZEALAND AND AUSTRALIAN GRASS-FED BEEF: Made in small batches in the USA without GMOs, fillers, or flow agents and third party verified for purity, our supplements for kidney health are sourced from 100% grass fed cows, pasture-raised without hormones in green fields.
- DENSE NUTRITION FOR VITALITY AND ENERGY: As the founders of the Beef Organ Movement, our mission is to make vital nutrition through the highest possible quality organ consumption accessible for all, putting back in what the modern world has left out.
$44.00
Seeking Health Histamine Digest - Formerly Histamine Block, DAO Enzyme Supplement for Histamine Food Intolerance, Supports Digestive Health, Upset Stomach, Vegetarian (30 Capsules)*
- Histamine intolerance support: Histamine Block is now Histamine Digest! Enjoy the freedom to eat your favorite histamine-containing foods and drinks again. This DAO digestive enzyme, also known as Diamine Oxidase, even allows you to enjoy that glass of wine without histamine-related headaches. Bring Histamine Digest wherever you want to enjoy high-histamine foods and drinks
- Fast-acting: Take 1 capsule no more than 15 minutes before the consumption of histamine-rich foods or drinks, or as directed by your healthcare provider, to keep histamine intolerance symptoms like gas and bloating at bay, and experience gastrointestinal relief. It is not designed to allow you to eat foods to which you are allergic, and it will not prevent allergic reactions
- Free from: Eggs, fish, gluten, GMO, milk, peanuts, shellfish, soy, tree nuts, wheat, corn, artificial colors, artificial flavors, and artificial preservatives
- Marked for freshness: Quality matters at Seeking Health. That’s why we conduct stability testing for all our products. Because testing can take up to 2 years, it’s not always possible to mark newer releases with an expiration date. That’s why we mark some items with the date they were made on, or MFG; so you know you’re getting the freshest product possible
- Consistent quality: At Seeking Health, every ingredient is carefully sourced, researched, and tested. Each meets strict specifications for manufacturing and quality standards before any ingredient is allowed for use
$36.50
Life Extension Food Sensitivity Relief with Diamine Oxidase (DAO), Occasional Gas, Digestive Comfort, histamine Sensitivity, DAO Enzyme Supplement, Gluten Free, Non-GMO, Vegetarian, 60 Capsules
- Gastrointestinal comfort – Get relief from occasional gas and stomach upset, as well as other gastrointestinal discomforts caused by histamine-rich foods like cured meats, cheese and wine
- Histamine metabolism – Diamine oxidase supports the healthy breakdown of intestinal histamine. This in turn helps relieve occasional non-allergy digestive discomfort associated with dietary histamine sensitivity.
- Plant-based DAO – Many DAO formulas utilize enzymes derived from animals (usually pork). But our formula uses diamine oxidase from pea sprouts.
- Ingredients matter – We use the finest raw ingredients with the quality and purity you deserve. The majority of our products are non-GMO, gluten-free and manufactured in the USA—and a Certificate of Analysis is available for every one.
- Live your healthiest life – We believe the answers to a healthier life are in reach, and that scientific research is the key to getting there. That’s why so many of our formulas feature specific ingredients and amounts based on scientific studies.
$28.50
Healthy Gut HistaHarmony | Delayed Release DAO Diamine Oxidase Histamine Support Enzyme | 30,000 HDU | 60 Servings
- Supports Histamine Balance: Helps your body break down histamine from food, promoting a more comfortable digestive experience. HistaHarmony lets you enjoy even a glass of wine without histamine-related headaches.
- Fast-Acting Formula: Designed for quick absorption, so you can enjoy your meals again without any worry.
- Advanced Enzyme Technology: Features ProDAOX for enhanced enzymatic activity and efficient histamine metabolism.
- Gut-Friendly & Gentle: Enteric-coated tablets protect the enzyme, ensuring effectiveness without any stomach discomfort.
- Quality You Can Trust: Free from artificial additives, gluten, and dairy, and made with high safety and purity standards.
$38.99
Omne Diem DAO 30,000 HDU - 60 Caps - Histamine Neutralizing Enzyme - Relieve Histamine Intolerance with Diamine Oxidase - The Original Tested DAO Enzyme Supplement
- Powerful Histamine Support with Natural DAO Enzyme – OmneDiem Histamine Digest provides 30,000 HDU of Diamine Oxidase (DAO) per serving, a crucial enzyme responsible for breaking down histamine in the gut. This high-potency formula helps individuals with histamine intolerance enjoy a wider variety of foods without unwanted reactions. By targeting histamine directly in the digestive tract, it reduces symptoms like flushing, bloating, nasal congestion, and headaches caused by histamine-rich foods, promoting overall digestive and immune health.
- Combat Histamine Sensitivity & Enhance Digestion – Designed for those sensitive to histamine, OmneDiem Histamine Digest helps mitigate histamine-induced discomfort before it starts. DAO works by degrading excess histamine from food, preventing it from triggering adverse reactions. Whether you're sensitive to aged cheeses, fermented foods, red wine, or cured meats, this supplement provides essential support to ease gastric distress, inflammation, and other histamine-related symptoms, ensuring greater meal tolerance.
- Fast-Acting Formula for Immediate Relief – Unlike general digestive enzymes, DAO targets histamine degradation at the source, working within 20 minutes of ingestion. Simply take it before consuming histamine-rich foods to help prevent symptoms like stomach pain, itching, dizziness, or skin reactions. The rapid-release vegetarian capsules ensure quick absorption, making it an effective tool for maintaining digestive balance, supporting gut health, and improving food tolerance in those with histamine intolerance.
- Non-Systemic & Clinically Proven for Safety – OmneDiem Histamine Digest is formulated with clinically tested DAO, acting exclusively in the digestive tract without affecting overall histamine levels in the body. Unlike antihistamines, which block histamine receptors, DAO naturally breaks down histamine without entering the bloodstream. This non-systemic, side-effect-free approach makes it a safe and reliable solution for daily histamine intolerance management, improving overall gut function and well-being.
- Supports a Balanced Diet & Quality of Life – Histamine intolerance can limit food choices and impact daily comfort, but OmneDiem Histamine Digest allows for greater dietary freedom. By reducing histamine overload, it helps alleviate common symptoms such as flushing, nasal congestion, digestive disturbances, and skin reactions, allowing you to enjoy meals without worry. Whether you’re dining out or following a histamine-restricted diet, this DAO supplement provides the digestive support needed for optimal health and well-being.
$54.95
NATURDAO Plus – 1,000,000 HDU per dose - DAO Enzyme and Catalase Enzyme - 8 Cofactors and Adjuvants to Help Boost Your Own DAO - Advanced Histamine Blocking Formula - Food Intolerance - 60 Tablets
- ✔ BOOST YOUR DAO · Experience a potent lift in your body's DAO levels with NaturDao Plus, designed for superior histamine breakdown and enhanced absorption. Simple and strong!
- ✔ NATURDAO PLUS offers the perfect combination of science, innovation and a premium LegumActive formula. It is cruelty-free, gluten-free, GMO-free, and 100% vegan.
- ✔ MAXIMUM BIOAVAILABILITY · Naturdao Plus is formulated to maximize the absorption of all of its ingredients. This is done by activating the ingredients through methylation, phytosomization, and liposomization.
- ✔ ESSENTIAL ACTIVATED INGREDIENTS · CO-FACTORS: Liposomal Ascorbic Acid, Zinc, Methylated Pyridoxal-5-Phosphate and Copper. ADJUVANTS: Phytosome Quercetin, Methylated 5-Methyltetrahydrofolate, Methylcobalamin and Catalase.
- ✔ ATTENTION This product contains nothing other than what is labeled. AVOID if allergic to any of the ingredients printed on the label. No food colours or genetically modified organisms.
$39.90
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−$4.00
XYMOGEN HistDAO - DAO Enzyme Supplement to Supports Healthy Degradation of Food-Derived Histamine - Diamine Oxidase for Digestive Health 20,000 HDU Per Serving (60 Tablets)
- All You Need In One Tablet - Our digestive enzyme supplement is a formula containing 20,000 HDU of diamine oxidase (DAO) enzymes per tablet. This product has been reformulated from 2 capsules to 1 single tablet needed to get a full serving of dao.
- Clinically Tested - Unlike standard digestive enzymes used for digestion support, this enzyme has been clinically tested and found to break down food-derived histamine in the digestive tract.*
- Digestive Support - Enhances the presence of diamine oxidase enzyme in the digestive tract. DAO is not absorbed and does not have systemic activity.*
- Multi-Benficial Supplement - This unique enzyme encompasses our immune support, digestive health and gastrointestinal support categories.*
- Formulated to Exclude - Wheat, gluten, yeast, soy, dairy products, fish, shellfish, peanuts, tree nuts, egg, artificial colors, artificial sweeteners, and artificial preservatives. Our DAO supplements are practitioner trusted.
$64.00
Designs for Health HistaGest-DAO - Diamine Oxidase DAO Enzyme to Support Digestion of Histamine-Containing Foods - 20,000 HDU DAO Diamine Oxidase Enzymes (60 Gastro-Resistant Tablets)
- Support Digestion of Food‑Derived Histamines - Lower DAO activity may result in higher levels of histamine being absorbed through the small intestine and accumulating in the blood. HistaGest-DAO provides supplemental diamine oxidase enzyme. Unlike common digestive enzyme products, this enzyme is responsible for breaking down food-derived histamine to help support normal and healthy histamine metabolism.*
- Convenient 'Take-Anywhere' Dispenser - This DAO supplement offers small tablet delivery in a convenient travel dispenser for portability and ease of use when on‑the‑go. Each tablet provides 20,000 histamine-degrading units (HDU) of diamine oxidase (DAO) from porcine kidney extract to promote the degradation of dietary histamines.*
- Just Take One Before Histamine-Rich Foods - Taking one diamine oxidase DAO supplement tablet before each meal promotes the amount of DAO in the small bowel to help break down histamine in the digestive tract, support digestive health and soothe digestive discomfort associated with sensitivity to histamine-rich foods.*
- Delayed-Release Tablets Designed for High Performance - DAO supplements can be less effective if they do not reach the small intestine. HistaGest-DAO diamine oxidase supplement is made with gastro-resistant, coated tablets with delayed-release technology that allows the DAO enzyme to reach the small intestine where it performs its action.*
- Clinically-Trusted Care - DFH is the #1 practitioner supplement brand recommended by functional medicine professionals and the #1 practitioner supplement brand personally trusted by functional medicine professionals.**
$70.99
HISTAsolv Extra Strength DAO Enzyme Supplement for Histamine Food Intolerance - Eases Digestive Discomfort - Patented Tech - Made in Austria - 10 Pack
- ENJOY THE FOODS YOU LOVE AGAIN: HISTAsolv provides fast, effective relief from histamine intolerance, helping you enjoy histamine-rich foods and drinks without the discomfort of symptoms like flushing, headaches, or digestive issues. Not for food allergies
- MAXIMUM POTENCY & PERFORMANCE: Each high-potency tablet is nitrogen-packed in a sealed blister and foil pouch, protecting it from air degradation to ensure freshness and maximum histamine-fighting power
- FAST AND CONVENIENT RELIEF: Take 1 tablet 15 minutes before consuming histamine-rich food or drink for quick results; Compact blister pack for on-the-go use; Love it or get an Amazon refund - no return required
- PATENTED PRECISION COATING: Our enteric-coated tablets ensure HISTAsolv’s high-potency DAO enzyme survives stomach acid and reaches the small intestine, helping your body naturally break down histamine for maximum relief
- SCIENTIFICALLY TESTED & MADE IN AUSTRIA: Each HISTAsolv Extra Strength tablet (36,000 HDUs) rapidly increases DAO levels in the small intestine to neutralize food histamine as it arrives; Gluten and Lactose Free
$15.97
Last update on 2025-05-01 / Affiliate links / Images from Amazon Product Advertising API