Cold sore medicine is essential for managing the discomfort and appearance of herpes simplex virus outbreaks. In 2025, the market offers a variety of effective treatments, ranging from topical creams to oral antivirals, each designed to alleviate symptoms and speed up healing. Some of the top-rated options include acyclovir, docosanol, and natural remedies like lemon balm. These products not only help reduce the duration of outbreaks but also provide relief from pain and itching. Choosing the right cold sore medicine can make a significant difference in your recovery and overall comfort.
SALE
−$9.23
Abreva 10 Percent Docosanol Cold Sore Treatment, Treats Your Fever Blister in 2.5 Days - 0.07 oz Tube x 2
- Number 1 Cold Sore Brand: Two 0.07 oz tubes of Abreva 10 Percent Docosanol Cold Sore Treatment
- Can Heal in 2.5 Days: Fever blister cream contains 10 percent docosanol to shorten the duration of cold sore symptoms (1)
- Nothing Heals Fever Blisters Faster: 10 percent docosanol cream penetrates deep into skin to tackle cold sores at their source (1, 2, 3)
- Lip Cream Clinically Proven to Shorten Duration of Symptoms: Cold sore product shortens duration of tingling, pain, burning and itching associated with cold sores (1)
- Portable Cold Sore Cream: Packaged in a convenient tube for on the go cold sore treatment
$25.00
SALE
−$4.75
Campho Phenique Cold Sore and Fever Blister Treatment for Lips, Maximum Strength Provides Instant Relief, Helps Prevent Infection To Promote Healing, Original Gel Formula, 0.23 Oz
- Trusted: A favorite for cold sore and fever blister treatment for lips for over 130 years.
- Instant Relief: Formulated with camphor and phenol to temporarily inactivate the pain signals at the nerve endings in the skin to provide a local anesthetic (numbing effect) that stops the pain and itch of cold sores and fever blisters on contact.
- Helps Prevent Infection: Antiseptic properties help prevent infection to promote cold sore healing.
- Aloe Soothes and Moisturizes: Prevents dryness and cracking as cold sores and fever blisters dry out.
- Store at room temperature
$4.24
Abreva Cold Sore Treatment Rapid Pain Relief Cream - 1 Tube, 3 Grams
- One tube of Abreva Cold Sore Rapid Pain Relief, 3 grams.
- Shortens duration of tingling, pain, burning and itching
- Easy applicable tube form for on-the-go use
- When you feel pain and burning from the cold sore or blister, Abreva has you covered with Abreva Rapid Pain Relief gel
- It delivers quick, targeted relief from the first application
$12.47
TARO Cold Sore/Fever Blister Treatment - Docosanol 10% Cream (0.07 oz - 2 Tube)
- Docosanol Cream 10% – Treats cold sores/fever blisters
- Treats Cold Sores / Fever Blisters on the Face or Lips
- Shortens Healing Time and duration of Symptoms
$14.99
SALE
−$4.00
Mederma Fever Blister Discreet Healing Patch - A Patch That Protects and Conceals Cold Sores - 15 Count
- INSTANTLY HIDES COLD SORES: Avoid the social embarrassment of a cold sore; the discreet protective barrier instantly hides unsightly fever blisters on the lips or mouth
- FASTER HEALING: The patch hydrocolloid gel technology creates an optimal healing environment so your skin heals fast
- 12 HOUR PROTECTION: Each patch provides up to 12 hours of non-stop protection from contamination to the cold sore; apply as early as day 1 to relieve pain
- EASY TO USE: The discreet patches have a no touch applicator; they're easy to apply and they stay in place to help conceal your cold sore
$9.99
SALE
−$2.51
Quantum Health Lip Clear Lysine+ Cold Sore Treatment Soothe & Moisturize Mouth Sores - L-Lysine Menthol Calendula & Propolis Ointment - Transparent Fever Blister Healing Balm - 0.25 Oz
- HALVE YOUR HEALING TIME - Cut cold sore healing time by 50% with the power of L-Lysine, a scientifically researched amino acid that inhibits arginine activity, nourishes skin and accelerates recovery.
- FAST-ACTING PAIN & ITCH RELIEF - Experience rapid relief from cold sore pain, burning, and itching discomfort with the cooling effect of Menthol plus 14 herbal ingredients to soothe and nourish your skin.
- HERBAL LIP TREATMENT - Harness the power of our nutrient-rich formula with Calendula, Vitamin E, and Propolis, providing deep moisturization and skin-nourishing properties for overall lip health.
- DISCREET COMFORT - Invisible balm can be worn under lipstick or gloss without worry, doesn't burn upon application, and offers relief from tingling, itching, burning, and other discomforts associated with cold sores.
- ROUND OUT YOUR LIP CARE ROUTINE - For optimal results use Lysine+ Ointment with our Super Lysine Immune Support Tablets and Lip Clear Invisible Cold Sore Patch to calm cold sores and promote faster healing.
$7.48
Last update on 2025-05-02 / Affiliate links / Images from Amazon Product Advertising API