Cold medicine for runny nose can provide much-needed relief during the uncomfortable days of a cold. In 2025, several options stand out for their effectiveness in alleviating symptoms. These medications often contain antihistamines, decongestants, or a combination of both to help dry up nasal passages and reduce mucus production. Popular choices include well-known brands that have been trusted for years, as well as newer formulations that promise faster relief with fewer side effects. When selecting the right cold medicine, it's essential to consider your specific symptoms and any underlying health conditions.
SALE
−$1.19
Boiron ColdCalm Tablets for Relief of Common Cold Symptoms Such as Sneezing, Runny Nose, Sore Throat, and Nasal Congestion - Non-Drowsy - 60 Count
- MULTI-SYMPTOM COLD RELIEF: ColdCalm Tablets relieve common cold symptoms, including sneezing, runny nose, nasal congestion, and minor sore throat, at every stage of the cold.* Non-drowsy relief with no known drug interactions for ages 4 and up.
- MELTAWAY CONVENIENCE: ColdCalm Tablets dissolve easily in the mouth without the need for water, chewing or swallowing, so you can act fast against cold symptoms anywhere, anytime.
- HELP YOUR BODY THE NATURAL WAY: This homeopathic cold medicine is non-drowsy and non-habit forming and can be taken day or night. It’s also gluten-free and contains no artificial sweeteners, flavors, colors, or preservatives.
- A TRUSTED BRAND: With more than 90 years of expertise, Boiron medicines are manufactured to meet the highest standards of cGMP and HPUS for purity and quality.
- BUY WITH YOUR HSA/FSA: Many of your favorite Boiron medicines are now eligible for reimbursement. Look for our logo designating products that can be paid for with your Health Savings Account or Flexible Savings Account.
$9.99
Coricidin HBP Decongestant-Free Cough and Cold Medicine - Specially Designed Relief for High Blood Pressure, Cough, Runny Nose, Sneezing and Cold Symptoms (16 Count)
- The no.1 brand that gives powerful cold symptom relief without raising your blood pressure
- Provides fast, powerful cold relief for people with high blood pressure
- Cold and cough medicine for adults that relieves cough, runny nose, and sneezing
- Decongestant free, cough cold medicine
- Cold medicine comes in tablet form
$8.99
SALE
−$2.95
Mucinex Sinus-Max Max Strength Day & Night Liquid Gels 24 ct
- MAXIMUM STRENGTH MUCINEX SINUS-MAX DAY: Helps relieve pain, sinus pressure, headache, nasal and chest congestion and thins and loosens mucus
- MAXIMUM STRENGTH MUCINEX SINUS-MAX NIGHT: Helps relieve pain, sinus pressure, nasal congestion, cough, and runny nose and sneezing
- TRUSTED COLD and COUGH BRAND: Cold and Cough brand doctors trust
- ACTIVE INGREDIENTS IN DAY: Contains Acetaminophen for pain relief, Dextromethorphan HBr for cough suppression, Guaifenesin as an expectorant and Phenylephrine HCl for nasal decongestion
- ACTIVE INGREDIENTS IN NIGHT: Contains Acetaminophen for pain relief, Dextromethorphan HBr for cough suppression, Doxylamine Succinate as an Antihistamine and Phenylephrine HCl for nasal decongestion
$15.54
SALE
−$2.49
Sudafed PE Sinus Congestion Day + Night Maximum Strength Decongestant & Antihistamine Tablets with Phenylephrine HCl & Diphenhydramine HCl, Helps Nasal & Sinus Pressure & Congestion, 20 ct
- 20-count of Sudafed PE Sinus Congestion Day + Night Maximum Strength Decongestant Medicine Tablets to temporarily relieve sinus pressure and sinus congestion for both day and night
- Each multi-pack contains 20 tablets of nasal decongestant, with 12 Daytime and 8 Nighttime tablets for powerful symptom relief throughout the day and while you sleep
- Each daytime and nighttime dose contains 10 milligrams of the nasal decongestant phenylephrine HCl per tablet and each nighttime dose also contains 25 milligrams per tablet of the antihistamine diphenhydramine HCl
- Both formulas help relieve sinus pressure and sinus congestion, and nasal congestion due to the common cold, hay fever, or upper respiratory allergies. Nighttime tablets also relieve sneezing, runny nose, itchy, watery eyes and itchy throat or nose
- From the #1 pharmacist recommended brand among oral OTC decongestants, this maximum-strength formula can be used by adults and children 12 years and older for powerful symptom relief
$8.18
Contac Non-Drowsy Day & Multi-Symptom Night Cold & Flu Medicine, Maximum Strength Relief for Fever, Sore Throat, Nasal Congestion, Head & Body Aches, Runny Nose, 28 Count, 16 Day, 12 Night Caplets
- FAST-ACTING, MAXIMUM-STRENGTH RELIEF: Get 24-hour relief from common cold & flu symptoms, including nasal congestion, sinus congestion and pressure, sore throat, head & body aches and fever, runny nose, and sneezing
- NON-DROWSY, DAYTIME RELIEF: Our severe cold & flu medicine provides symptom relief without making you drowsy; Stay alert and active throughout your day
- NIGHTTIME COMFORT: Sleep better with our nighttime formula that eases symptoms for restful sleep
- 24-HOUR RELIEF: Feel better and stay alert by using our daytime formula with Phenylephrine HCI a nasal decongestant to ease congestion and acetaminophen a pain reliever/fever reducer to relieve minor aches, pains and sore throat; get some rest at night with our nighttime formula that also contains Chlorpheniramine maleate an antihistamine to ease your symptoms overnight
- FIGHT THE FLU & COLD: Contac Cold + Flu tackles severe cold & flu symptoms for adults and children 12 years and older; FSA/HSA eligible, gluten-free and no artificial colors
$8.49
SALE
−$1.00
Zicam Cold Remedy No-Drip Nasal Spray with Cooling Menthol & Eucalyptus, Homeopathic, Zinc-Free, Pre-Cold Medicine, Shortens Cold Duration, 0.5 Ounce
- ZICAM HOMEOPATHIC REMEDIES: Known for Zicam Cold Remedy products, we also offer products for homeopathic allergy relief, homeopathic cold relief for kids, & nasal congestion & sinus relief
- MULTI-SYMPTOM COLD RELIEF: Zicam's plant-based formula provides multi-symptom cold relief to hep open your nasal passages, so you feel better, faster; Help calm your cold with Zicam Cold Remedy products like nasal spray & swabs or our RapidMelt tablets
$9.99
SALE
−$2.63
Alka-Seltzer Plus Maximum Strength Power Max Sinus, Allergy and Cough Medicine for Adults and Children 12 Years and Older - Relieves Symptoms from Allergies, Colds or Hay Fever, 24 Count
- Alka-Seltzer Plus Maximum Strength Powermax gels provide powerful allergy and sinus relief *Use as directed.
- Get the fast, effective relief from colds, hay fever, and allergy symptoms when you need it.
- ASP Sinus, Allergy & Cough medicine contains a pain reliever / fever reducer, cough suppressant, antihistamine and a nasal decongestant.
- This sinus, allergy, and cough medicine contains an antihistamine which helps to reduce allergy symptoms like sneezing, runny nose, and itchy/watery eyes.
- This Sinus, Allergy & Cough relief medicine also contains cough suppressant and nasal decongestant to help relieve cough, nasal congestion, sinus congestion and pressure.
$7.86
SALE
−$2.52
Alka-Seltzer Plus Severe, Cold & Flu Medicine, Citrus Effervescent Tablets, Nasal & Sinus Congestion, Sneezing, Runny Nose, Cough, Sore Throat 24 Count, Packaging May Vary
- Our fantastic formula made even better: improved flavor, less sodium, & aspartame free
- Our severe Cold & Flu medicine formula provides unbeatably liquid fast relief of headache, sore throat, cough, nasal & sinus congestion, runny nose, sneezing, aches & pains and fever.
- Quickly dissolves in water and instantly ready to start working so you can get back to your busy life.
- Each box containing 10 Sachets each containing 1 individually wrapped dose (2 effervescent tablets), which makes it easy to take with you on the go
- Comes in Effervescent form, in a refreshing Citrus flavor. Use as directed.
$9.47
SALE
−$3.00
Tylenol Cold + Flu Severe Medicine Caplets for Fever, Pain, Cough & Congestion, 24 ct.
- 24-count of Tylenol Cold + Flu Severe Pain Reliever & Fever Reducer Medicine Caplets provide effective relief of multiple symptoms due to the flu and common cold
- This severe cold & flu medicine helps relieve fever, headache, minor aches and pains, sore throat, nasal congestion, and cough. It also helps loosen phlegm (mucus) and thin bronchial secretions to make coughs more productive.
- Each caplet contains 325 mg of acetaminophen to help reduce fever and relieve minor aches & pains, as well as 10 mg of the cough suppressant dextromethorphan HBr to help quiet coughs
- Each caplet also contains 5 mg of the nasal decongestant phenylephrine HCl to help relieve congestion and 200 mg of the expectorant guaifenesin to help loosen phlegm (mucus) and make coughs more productive
- From the doctor-recommended pain relief brand, this cold & flu medicine is suitable for use by adults and children 12 years and older for powerful multi-symptom relief
$7.67
Last update on 2025-05-02 / Affiliate links / Images from Amazon Product Advertising API