Benzoyl peroxide spot treatment is a highly effective solution for targeting acne and blemishes, making it a staple in many skincare routines. In 2025, the market offers a variety of top-rated products that cater to different skin types and concerns. These treatments work by penetrating the pores to eliminate acne-causing bacteria and reduce inflammation, providing quick relief and clearer skin. Whether you prefer gels, creams, or patches, there’s a benzoyl peroxide spot treatment that can help you achieve your skincare goals.
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−$3.71
Neutrogena Rapid Clear Stubborn Acne Spot Treatment Gel with Maximum Strength 10% Benzoyl Peroxide Acne Treatment Medication, Pimple Cream for Acne Prone Skin Care, 1 oz
- 1-ounce tube of Neutrogena Rapid Clear Stubborn Acne Spot Treatment Gel with maximum-strength 10% benzoyl peroxide acne medication to help fight acne and prevent future breakouts for clearer looking skin
- This effective acne-fighting spot gel is clinically proven to rapidly reduce the size and redness of stubborn acne in just 2 hours and actively fights breakouts, for continuous improvement in skin's appearance throughout the day
- Its maximum strength formula contains 10% benzoyl peroxide, the acne medication dermatologists recommend most for clearer skin without a prescription
- From a dermatologist recommended brand, this maximum-strength daily stubborn acne treatment is specially formulated for acne-prone skin to help manage acne and clear breakouts
- Cleanse skin thoroughly before applying acne pimple spot treatment gel then proceed to cover affected area with a thin layer of acne gel 1 to 3 times daily
$9.68
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−$4.00
Neutrogena On-The-Spot Acne Treatment Gel with Benzoyl Peroxide - Gentle Face Acne Medicine for Acne Prone Skin, 0.75 oz
- .75-ounce tube of Neutrogena On-The-Spot Acne Spot Treatment cream with benzoyl peroxide to fight acne while gentle on skin
- Vanishing cream formula of this acne spot treatment is lightweight, absorbs quickly and works invisibly hour after hour to give long-lasting acne treatment
- On-The-Spot treatment is clinically proven to be so effective that skin starts getting clearer on day 1 to without over-drying, stinging or burning skin
- This gentle daily acne blemish treatment can be used up to three times a day. It's formulated with 2.5% benzoyl peroxide acne medicine, to help treat and prevent acne
- The acne-fighting formula goes deep down into pores to kill acne bacteria that causes pimples and helps stop new ones from forming
$7.99
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−$3.32
AcneFree Terminator 10 Acne Spot Treatment with Benzoyl Peroxide 10% Maximum Strength Acne Cream Treatment, 1 Ounce - Pack Of 1
- Severe Acne Spot Treatment: Maximum strength, 10% Benzoyl Peroxide fights severe acne and prevents new acne from forming. Dermatologist developed and tested; Oil free and fragrance free
- Reduces Redness and Soothes: Ginger is an effective treatment for acne, fighting active blemishes and treating skin until cleansing while Chamomile soothes
- Healthy Skin Solutions: We carry a full line of treatment kits, cleansers, moisturizers, detox masks, scrubs, creams, toners and other targeted solutions for sensitive, oily and acne prone skin
- Dermatology Inspired Care: Our products offer hydration, soothing, detoxifying and mattifying benefits to help ensure your skin looks and feels healthy and help maintain your skin’s balance with consistent use
- Dermatologist Recommended: Built on a foundation of dermatological science and research, doctors consistently recommend our products to men, women, teens and adults in need of gentle yet effective acne treatment
$4.67
Differin Acne Spot Treatment with 10% Benzoyl Peroxide, Maximum Strength OTC Acne Treatment, Fast Acting Spot Treatment for Face, 1 oz
- MAXIMUM STRENGTH 10% BENZOYL PEROXIDE: One 1 oz tube of Differin Acne Spot Treatment with 10% benzoyl peroxide as the strongest over-the-counter (OTC) concentration to visibly reduce acne size and redness after 1 use.
- FAST BLEMISH SPOT TREATMENT: Penetrates deep into pores and works to immediately kill acne-causing bacteria
- FOUR-IN-ONE ACNE TREATMENT FOR FACE: Acne solution that treats imperfections, prevents acne, targets acne-causing bacteria, and improves skin texture
- FORMULATED WITH GLYCERIN: While benzoyl peroxide starts clearing acne blemishes, glycerin helps to minimize dryness
- HOW TO USE: After cleansing with a gentle face wash, apply spot treatment on dry skin directly on affected areas, followed by moisturizer and SPF, and reapply as needed
$9.97
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−$2.02
Clean & Clear, Persa-Gel 10 Acne Spot Treatment, Maximum Strength, 1 Oz
- 1-ounce tube of Clean & Clear Persa-Gel 10 Oil-Free Acne Spot Treatment with Maximum Strength 10% Benzoyl Peroxide acne medication to help effectively treat pimples and reduce acne in just one day
- Fragrance free acne spot treatment is ideal for inflamed acne bumps. The face gel contains micronized benzoyl peroxide acne medication that goes to work immediately to help fight pimples and blemishes
- The benzoyl peroxide spot treatment for acne penetrates deep down into pores where acne begins. The acne treatment visibly reduces blemish size and acne redness in just one day
- This maximum strength acne treatment is formulated free of parabens, phthalates, fragrance, oil and dyes. It features a vegan formula that is not tested on animals and is packaged in a recyclable carton
- Suitable for acne-prone or oily skin, fragrance free Persa-Gel 10 reduces acne in just one day. To use, clean the skin and apply a thin layer of spot treatment to affected areas one to three times a day as a part of your daily acne skincare routine
$5.97
Amazon Basics 10% Benzoyl Peroxide Acne Medication, Maximum Strength, 1 Fluid Ounce Face Gel
- One 1-fluid ounce tube of benzoyl peroxide acne medication for the treatment of acne
- Dermatologist tested for Treatment of Acne
- Compare to Clean and Clear Persa-Gel 10 maximum strength
- Active ingredient: 10% Benzoyl Peroxide acne medication
- An Amazon Brand
$5.24
Paula's Choice CLEAR Daily Skin Clearing Treatment with Benzoyl Peroxide, Treats and Prevents Mild to Severe Acne & Breakouts, Fragrance-Free, 2.25 Fl. Oz.
- FIGHTS ACNE WITHOUT DRYING SKIN: This daily-use, highly-effective acne treatment works on contact to minimize acne, prevent future breakouts, calm redness, and control excess oil while hydrating skin to diminish dryness and flaking. No harsh or aggravating ingredients that leave skin looking red, irritated, or uncomfortable.
- Paula's Choice CLEAR Daily Skin Clearing Acne Treatment is uniquely-formulated to fight acne using benzoyl peroxide while also hydrating & soothing skin with non-fragrant, nourishing plant extracts. This blemish-fighting solution works well for all skin types and it's even suitable for skin prone to cystic acne.
- Formulated with benzoyl peroxide to help fight existing acne breakouts & prevent future blemishes on the face and body, this effective treatment delivers best results when used daily. Apply after cleansing and exfoliating, always finishing with an SPF 30 or greater for daytime use. Sets to an invisible matte finish & looks great under makeup.
- Paula's Choice CLEAR collection also includes the Pore Normalizing Cleanser with 0.5% Salicylic Acid (BHA), an Anti-Redness Exfoliating Solution with 2% Salicylic Acid (BHA), and our Ultra-Light Daily Hydrating Fluid SPF 30+.
- SUSTAINABLE PACKAGING: As part of our pledge to the planet, we’re removing extra plastic from packaging, like shrink wrap.
$24.00
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−$1.47
Clearasil Stubborn Acne Control 5in1 Spot Treatment Cream, Maximum Strenght with 10% Benzoyl Peroxide, Acne Medication, 1 oz
- Clears existing pimples and helps prevent new ones from forming
- Vanishing acne cream formula penetrates pores to treat pimples
- 24 hour control works with your skin long after application
- With this acne cream you get visibly clearer skin every day.
- Dermatologist tested
$5.27
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−$4.22
Perrigo 10% Benzoyl Peroxide Acne Treatment Gel 2.1 oz
Last update on 2025-05-03 / Affiliate links / Images from Amazon Product Advertising API