Arthritis cream for knees can provide significant relief for those suffering from joint pain and inflammation. In 2025, the market offers a variety of effective options that cater to different needs, from natural ingredients to advanced formulations. These creams not only help alleviate discomfort but also promote mobility, making daily activities more manageable. Whether you prefer a menthol-based solution for immediate cooling relief or a more holistic approach with herbal extracts, there’s a product that can suit your preferences. Explore the top choices to find the best arthritis cream for knees that works for you.
Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief with Diclofenac - NEW Easy Open Cap - 150 g
- One 5.3 oz/150 g tube of Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief- Easy flip cap that can be opened with your palm, fingers, or even with just one hand; packaging may vary
- Number 1 Doctor Recommended topical pain relief brand
- Clinically Proven to relieve arthritis pain, improve mobility and reduce stiffness, aches and pains to provide prescription strength arthritis pain relief
- An Alternative to Pills, Voltaren is a nonsteroidal anti-inflammatory gel that combines the benefits of an arthritis cream and gel for arthritis pain management
- Voltaren Arthritis Pain Gel Penetrates Deep to attack arthritis pain directly at the source of inflammation, treating arthritis pain
$23.93
SALE
−$8.22
Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief with Diclofenac - NEW Easy Open Cap - 100 g x 2
- Two 3.5 oz/100 g tubes of Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief- Easy flip cap that can be opened with your palm, fingers, or even with just one hand; packaging may vary
- Number 1 Doctor Recommended topical pain relief brand
- Clinically Proven to relieve arthritis pain, improve mobility and reduce stiffness, aches and pains to provide prescription strength arthritis pain relief
- An Alternative to Pills, Voltaren is a nonsteroidal anti-inflammatory gel that combines the benefits of an arthritis cream and gel for arthritis pain management*
- Voltaren Arthritis Pain Gel Penetrates Deep to attack arthritis pain directly at the source of inflammation, treating arthritis pain
$24.27
Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief with Diclofenac, No Prescription Needed - 1.7 oz/50 g Tube
- One 1.7 oz/50 g tube of Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief
- Number 1 Doctor Recommended topical pain relief brand
- Clinically Proven to relieve arthritis pain, improve mobility and reduce stiffness, aches and pains to provide prescription strength arthritis pain relief
- An Alternative to Pills, Voltaren is a nonsteroidal anti-inflammatory gel that combines the benefits of an arthritis cream and gel for arthritis pain management
- Diclofenac Sodium Topical Gel Penetrates Deep to attack arthritis pain directly at the source of inflammation, treating arthritis pain
$10.98
SALE
−$4.80
Boiron Arnicare Arthritis Cream for Pain Relief of Knees, Hands, Wrists, Elbows, Joints & Muscles – Quickly Absorbed & Fragrance-Free – 2.5 oz
- DUAL ACTION: Scientifically formulated with Arnica Montana and Harpagophytum (Devil’s Claw) for dual action pain relief. Addresses minor arthritis pain at its source and is suitable for use on all joints.
- TOPICAL PAIN RELIEF: The non-greasy light, silky texture quickly absorbs into skin is ideal for sudden flare-ups and soreness.
- PLANT-BASED ACTIVE INGREDIENT: Arnica Montana and Harpagophytum are natural pain relievers. No camphor, menthol, or other ingredients that cause burning or stinging and is paraben-free.
$13.15
Penetrex Joint & Muscle Therapy - Soothing Comfort for Back, Neck, Hands, Feet - Premium Whole Body Rub with Arnica, Vitamin B6 MSM & Boswellia - Non-Greasy 2oz Cream
- Effective for Joints and Muscles: Penetrex is the whole-body therapy cream you’ve been waiting for; trusted by over 2 million sufferers; offers a different kind of comfort
- The Penetrex Difference: Our proprietary blend of natural ingredients leverages the power of arnica, vitamin B6 and MSM to penetrate deeply for joint and muscle discomfort at the source
- Premium Experience: Penetrex is a non-greasy, non-sticky, non-staining, paraben-free, cruelty-free and vegan soothing cream without the burn, freeze or strong odor of other products
- See Why So Many People Trust Penetrex: Penetrex allows you to get back to doing the things you love
- Directions: Apply to back, neck, knee, hand, foot, and more; Penetrex can be used on its own or with other therapies such as heating pads, ice packs, massagers and supplements; apply 3-4 times per day for 7-10 days, then apply as needed
$16.98
Aspercreme Original Pain Relief Cream for Arthritis, Joint & Muscle Pain, Non-Greasy Topical Analgesic with Moisturizing Aloe & Max-Strength 10% Trolamine Salicylate, 3 oz.
- Contains: One (1) 3-oz. tube of Aspercreme Original Max-Strength Pain Relief Cream for arthritis, backache, muscle strains, sprains and bruises
- Fast-Acting Relief: Experience rapid soothing with max-strength trolamine salicylate, clinically proven for arthritis, joint and muscle pain
- Non-greasy Application: Fragrance-free Aspercreme pain relief cream applies without leaving behind greasy residue or strong odor
- Maximum-Strength Trolamine Salicylate: OTC Aspercreme offers pain relief with maximum-strength trolamine salicylate, and is FSA/HSA eligible
- Travel-Size Tube: Packaged in a compact and portable container, so you can take your pain relief solution wherever you go
$6.58
SALE
−$1.33
Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief with Diclofenac - NEW Easy Open Cap - 100 g Tube And 20 g Travel Size Tube
- One 3.5 oz/100 g tube and one 0.71 oz/20 g travel size tube of Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief- Easy flip cap that can be opened with your palm, fingers, or even with just one hand; packaging may vary
- Number 1 Doctor Recommended topical pain relief brand
- Clinically Proven to relieve arthritis pain, improve mobility and reduce stiffness, aches and pains to provide prescription strength arthritis pain relief
- An Alternative to Pills, Voltaren is a nonsteroidal anti-inflammatory gel that combines the benefits of an arthritis cream and gel for arthritis pain management
- Voltaren Arthritis Pain Gel Penetrates Deep to attack arthritis pain directly at the source of inflammation, treating arthritis pain
$21.96
SALE
−$5.02
Blue Emu Muscle and Joint Deep Soothing Original Analgesic Cream, 1 Pack 12oz
- Blue-Emu is the go to brand for America's #1 Emu Oil Formula. The naturally powerful carrier oil allows ingredients such as Aloe Vera, MSM & Glucosamine absorb directly to your tired joints and muscles.
- Multiple use application! Apply to back, neck, shoulders, elbows, wrists, knees, hips, feet, hands, and ankles for daily soothing assistance.
- Get rid of that menthol stench. Our emu-oil based cream is odor free and is a non-greasy application. Irritation free!
- The deep penetrating cream gets below the skin in a hurry, no need to wait long periods of time for the soothing formula to kick in!
- Daily application is not only safe, it's recommended! Apply liberally 2-3 times daily for two weeks, and then as needed. In addition to soothing benefits, use the 12oz Original Super Strength Cream to help dry, chapped or weathered skin.
$28.48
Amish Origins Arthritis Pain Relief Cream - 3.5 oz - Maximum Strength Deep Penetrating for Joint, Muscle, Knee, Back, Feet, Hand, Ankle, Aches, 1 Pack
- Provides Fast Relief From Pain: Carefully Formulated With Active Ingredients That Target Pains, Amish Origins Deep Penetrating Pain Relief Cream Is Formulated To Provide Long-Lasting Relief From Pains Associated With Arthritis, Aching Joints, Sore Muscles, Restless Legs, Bruises, Sprains, Backache And More.
- Quick-Acting Pain Relief Formula: Amish Origin Medicated Pain Relief Cream Has Earned Its Reputation As One Of The Best On The Market, And That’S Because It Delivers On Its Promises. As A Powerful Pain Relief Cream, Amish Origins Pain Relief Cream Absorbs Quickly And Delivers Fast Relief From Pain.
- Greaseless Formula: While Other Pain Relief Formula Leave Behind Annoying Greasy Residues After Application, Not Amish Origins. This Is Because Amish Origins Is Carefully Formulated To Deeply Penetrate The Skin Without The Greasy Feel.
- Easy To Use: This Pain Relief Cream Is Easy To Use. Simply Apply A Little Amount Topically, Wherever You Feel Pain, And Watch The Magic Unfolds.
- Specially Formulated: To Provide Quick, Therapeutic, And Deep Soothing Relief From Pain, Amish Origins Deep Penetrating Pain Relief Cream Is Perfect For Treating Aching Joints, Restless Legs, Bruises, Arthritis, Headache, Muscle Strains, Backache, Sprains And More.
$19.99
Australian Dream Arthritis Pain Relief Cream - Soothing & Non-Greasy - Powerful Topical Arthritis Pain Relief - Good for Muscle Aches or Joints - 4 oz Jar
- Soothing Pain Relief: Our Australian Dream Arthritis Pain Relief Cream is easily absorbed, providing a powerful, effective formula for muscle and joint pains
- Powerful, Economical Relief: Our cream provides a powerful solution to your arthritis pain, and it doesn't take much to do the job
- Odorless & Non-Greasy: Our arthritis pain relief cream is non-greasy, odorless, and doesn't burn, making it perfect for sore muscles and painful joints
- High-Quality Formula: With histamine dihydrochloride, this pain cream provides temporary relief of minor aches and pains of muscles and joints associated with arthritis, simple backache, strains, sprains, and bruises
- Moving is Living: Australian Dream is dedicated to relieving pain and promoting comfort; this dedication is why we’re America’s first premium topical analgesic pain reliever
$24.99
Last update on 2025-05-01 / Affiliate links / Images from Amazon Product Advertising API