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10 Best antihistamine for sleep (2025) - Joe's Italian Restaurant & Pizza

10 Best antihistamine for sleep (2025)

Antihistamine for sleep are popular choices for those seeking relief from insomnia and restless nights. These medications work by blocking histamine receptors in the brain, promoting drowsiness and helping individuals fall asleep more easily. In 2025, several antihistamines stand out for their effectiveness and minimal side effects, making them ideal for occasional use. From diphenhydramine to doxylamine, these options cater to various preferences and needs, ensuring a restful night’s sleep for many.

SALE −$2.29

Amazon Basic Care Nighttime Sleep Aid Tablets for Adults, Doxylamine Succinate 25 mg, 96 Count

  • THE ACTIVE INGREDIENT in Amazon Basic Care Sleep Aid Tablets is doxylamine succinate 25 mg, a nighttime sleep aid which compares to the active ingredient in Unisom SleepTabs
  • FOCUS ON SLEEP: With a single one-tablet dose, Amazon Basic Care Sleep Aid Tablets with doxylamine succinate 25 mg as the active ingredient help reduce difficulty in falling asleep. This nighttime sleep aid contains no pain reliever and is gluten free
  • TESTED & EFFECTIVE: Clinically tested and proven effective, doxylamine succinate 25 mg sleep aid tablets are for adults and children ages 12 years and older
  • NIGHTTIME SLEEP AID: With just one tablet per dose, Amazon Basic Care Sleep Aid Tablets, Doxylamine Succinate Tablets 25 mg help to reduce difficulty in falling asleep. Use as a nighttime sleep aid
  • FALL ASLEEP: Sleep is important. One tablet per dose helps to reduce difficulty falling asleep. Gluten free

$10.30

Amazon Basic Care Allergy Relief Diphenhydramine HCl 25 mg, Antihistamine Tablets for Symptoms Due to Hay Fever and Upper Respiratory Allergies, 100 Count

  • ACTIVE INGREDIENT: Amazon Basic Care Allergy Relief tablets contain diphenhydramine HCl 25 mg, an antihistamine, which compares to the active ingredient in Benadryl Allergy Tablets
  • MULTI-SYMPTOM RELIEF: One dose provides temporary allergy relief of runny nose, sneezing, itching of the nose or throat and itchy, watery eyes; also temporarily relieves runny nose and sneezing due to the common cold
  • ANTIHISTAMINE: Each 25 mg pill packs a powerful dose of allergy-fighting medicine
  • MINI-TABS are easy to swallow; these small tablets offer big relief
  • NIGHTTIME ALLERGY RELIEF: Amazon Basic Care Complete Allergy Medicine calms your sneezing so you can rest
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$5.20
SALE −$4.30

Benadryl Extra Strength Allergy Relief Medicine, 50 mg Diphenhydramine HCl Antihistamine Tablets for Relief of Allergy Symptoms Due to Hay Fever or Other Upper Respiratory Allergies, 24 ct

  • ALLERGY RELIEF MEDICIATION: 24-count pack of Benadryl Extra Strength Antihistamine Allergy Relief Tablets each containing 50 mg of the antihistamine diphenhydramine hydrochloride for powerful allergy symptom relief
  • EXTRA STRENGTH SYMPTOM RELIEF: The allergy medicine provides relief from both indoor & outdoor allergy symptoms such as runny nose, sneezing, itchy, watery eyes, & itchy nose & throat. They also provide symptom relief for hay fever & the common cold
  • POWERFUL ANTIHISTAMINE: Formulated with 50 mg diphenhydramine HCl, the extra strength allergy tablets provide relief from hay fever or other upper respiratory allergy symptoms & cold symptoms such as sneezing & runny nose
  • FAST & EFFECTIVE: Benadryl Extra Strength Allergy Medicine in small, convenient antihistamine tablets provide effective allergy relief when you need it. Allergy medicine for multi-symptom relief is intended to be used by adults & children ages 12+
  • POWERFUL ALLERGY & COLD RELIEF IN JUST 1 PILL: Adults & children over 12 years of age, take one Benadryl Extra Strength Allergy Relief tablet every 4 to 6 hours, or as directed by a doctor, do not take more than 6 times in 24 hours

$8.17
SALE −$6.01

Unisom SleepTabs, Nighttime Sleep-aid, Doxylamine Succinate, 80 Tablets

  • INCLUDES: One (1) 80-count bottle of Unisom SleepTabs Nighttime Sleep-aid; one tablet per dose
  • FALL ASLEEP 33% FASTER*: Effective sleep aid helps you fall asleep faster* and stay asleep *versus placebo in a clinical study
  • NON-HABIT FORMING: SleepTabs are safe if used as directed, non-habit forming and help you sleep through the night and feel recharged without grogginess or lingering side effects
  • TRUST UNISOM, THE SLEEP EXPERT: The Pharmacist Recommended OTC Sleep-Aid Brand* *Data represents brand/product selections from the 2019 Pharmacy Times Survey of Pharmacists' OTC Recommendations
  • FIND A NIGHTTIME SLEEP SOLUTION RIGHT FOR YOU: Millions of people turn to Unisom for a restful night's sleep; Unisom SleepGels, SleepTabs, SleepMinis, SleepMelts or PM Pain can help you take on your day
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$13.98

A+Health Nighttime Sleep Aid Diphenhydramine 50 mg Softgels Maximum Strength, 160 Count

  • ACTIVE INGREDIENT: Contains active ingredient Diphenhydramine 50mg (non-habit forming sleep aid) in an easy-to-swallow capsule—compare to the active ingredient in Unisom SleepGels
  • MAXIMUM STRENGTH: These maximum strength diphenhydramine softgels are easy to swallow and offer fast-acting relief so you can get the sleep you need, fast
  • SLEEP AID: Diphenhydramine helps you feel sleepy by blocking the histamines that keep your body awake, helping you fall asleep quickly and enjoy deep sleep
  • OCCASIONAL RELIEF: Perfect for occasional relief from sleepless nights; Contains 160 liquid-filled capsules
  • GET THE SLEEP YOU NEED! Easy-to-swallow softgels help you past the hurdle of a large pill so you can get back on track

$10.40
SALE −$2.50

HealthA2Z® Allergy Relief | Loratadine 10mg | Antihistamine | Non-Drowsy | Relief from Itchy Throat, Sneezing, Runny Noses | 24-Hours Allergy Medicine (300 Tablets)

  • HealthA2Z Allergy Relief Loratadine 10mg Compare to Claritin Tablets Active Ingredient
  • Multi-symptom relief: HealthA2Z Allergy Relief provides allergy relief from sneezing, runny nose, itchy, watery eyes, and itchy nose or throat caused by allergens like pollen, dust mites, pet dander, and mold.
  • Non-drowsy: HealthA2Z Allergy Relief, Loratadine 10mg is a non-drowsy antihistamine. Avoid daytime sleepiness.
  • 24-hour allergy relief: HealthA2Z Allergy Relief, Loratadine 10mg allows you to get 24-hour allergy relief.
  • Adults: Take 1 tablet daily, no more than 1 tablet in 24 hours.
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$11.45
SALE −$5.14

Benadryl Liqui-Gels Antihistamine Allergy Medicine & Cold Symptom Relief, Dye-Free Liquid Gels with 25 mg of Diphenhydramine HCl for Symptoms Such As, Runny Nose, Sneezing & More, 48 ct

  • FAST-ACTING RELIEF: Liquid-filled softgels provide quick absorption to alleviate allergy and cold symptoms effectively.
  • POWERFUL ANTIHISTAMINE: Contains 25 mg of diphenhydramine HCl, a trusted ingredient for combating sneezing, runny nose, itchy throat, and watery eyes.
  • DYE-FREE FORMULA: Designed for those with sensitivities to artificial dyes while maintaining maximum efficacy.
  • MULTI-SYMPTOM RELIEF: Helps manage symptoms associated with allergies, hay fever, colds, and other respiratory irritants.
  • CONVENIENT LIQUID GELS: Easy-to-swallow capsules make it simple to get relief whether at home or on the go.

$9.97

Rite Aid Antihistamine Allergy Relief with Diphenhydramine | Allergy Medicine | Easy-to-Swallow Small Tablet Size Allergy Relief | Common Cold & Respiratory Allergy Medication (365 Count)

  • MULTI-SYMPTOM ALLERGY RELIEF: Rite Aid’s Sinus & Allergy Relief PE tablets offer temporary relief from sneezing, itchy, watery eyes, runny nose, and itching of the nose or throat. This allergy medicine calms hay fever or other respiratory allergies.
  • CONTROL INDOOR & OUTDOOR ALLERGIES: Allergies don’t stand a chance against Rite Aid Antihistamine allergy medicine for adults. Whether it’s pet dander or dust indoors or blooming grass and trees outside, Rite Aid will keep your allergies under control.

$14.99

Last update on 2025-05-03 / Affiliate links / Images from Amazon Product Advertising API