Antihistamine for hives are essential for managing the uncomfortable symptoms associated with allergic reactions. In 2025, several options stand out for their effectiveness and safety. These antihistamines work by blocking the action of histamine, a substance in the body that causes allergic symptoms such as itching, redness, and swelling. Popular choices include both first-generation and second-generation antihistamines, each offering unique benefits depending on individual needs. Whether you prefer a non-drowsy option for daytime relief or a stronger formula for nighttime use, there are plenty of effective antihistamines available to help alleviate hives.
Allegra Hives Antihistamine 24-Hour Tablets, Non-Drowsy Hive Reduction and Hive Itch Relief, 180 mg Fexofenadine HCI, 30-Count
- INCLUDES: One (1) 30-count pack of Allegra Hives Antihistamine 24-Hour Tablets, Non-Drowsy Itch Relief
- 24-HOUR RELIEF: One antihistamine pill is all you need for 24-hour relief
- NON-DROWSY: Formulated with active ingredient fexofenadine HCI, a non-drowsy OTC medication
- ITCH RELIEF: Allegra Hives itch relief medicine works from the inside to reduce hives and relieve itching due to hives
- REDUCES SYMPTOMS: Use Allegra tablets for hives related symptoms
$19.96
Curist Fexofenadine Hydrochloride 180 mg - 60 Antihistamine Tablets - 24 Hour Hives Treatment & Itch Relief for Adults USA Made - Itchy Skin Treatment - Non Drowsy - Hives Allergy Medicine
- HIVES REDUCTION & ITCH RELIEF - Hives can cause intense itching and irritation that can disrupt your daily life, but Curist Fexofenadine helps mitigate these symptoms by working effectively. Our fast-acting antihistamine tablets provide relief when you need it most!
- ALL DAY ITCH RELIEF FROM HIVES & ITCHY SKIN- Curist Hives Relief works from the inside to reduce hives and relieve itching for up to 24 hours - no need to take multiple doses during the day! Formulated with Fexofenadine Hydrochloride 180mg, take one tablet a day for hive relief.
- FEXOFENADINE 24 HOUR NON DROWSY FORMULA - Reduce the discomfort of hives associated with allergies without causing drowsiness. This powerful hives medicine works all day to help you stay focused and symptom-free.
- EASY TO SWALLOW TABLETS - These easy-to-swallow tablets are formulated with effective ingredients that help reduce symptoms associated with itchy and uncomfortable hives. With just one tablet a day, you can experience long-lasting results and fewer flare-ups.
- VAULE SIZE HIVES ALLERGY MEDICINE - Twice the number of tablets compared to the big brand Hives Relief. This means you’ll be able to purchase more and spend less when it comes to hive relief.
$15.99
SALE
−$2.19
Benadryl Anti Itch Gel, Relief of Outdoor Itches Associated with Poison Ivy, Topical Analgesic, Cooling Relief, Diphenhydramine, 3.5 oz
- ANTI ITCH GEL: Benadryl anti itch gel temporarily provides pain and itch relief associated with insect bites, minor burns, sunburn, minor skin irritation, minor cuts and scrapes, and rashes due to poison ivy and poison sumac.
- TOPICAL ANALGESIC: Topical cooling gel contains 2% of the topical analgesic pain reliver diphenhydramine hydrochloride that helps to relieve itches and minor pains on the skin; Provides relief from most outside itches.
- SOOTHING & COOLING GEL: Carry this topical anti itch analgesic gel to relieve uncomfortable skin irritation at home or on the go; Works when you need it most and provides cooling relief from minor pain to intolerable itchy skin.
- POISON IVY REIEF: Topical Analgesic to provide itch relief for most outdoor itches associated with poison ivy, insect bites; Dries the oozing and weeping of poison ivy, poison oak and poison sumac.
- INCLUDES: Pack of 1, 3.5 fl. oz. anti itch gel; Suitable for adults and children ages 2+; Provides itch relief for kids and adults alike and great to keep on hand during outdoor activities such as camping, hiking, or walking with the family.
$6.27
SALE
−$4.76
Boiron Histaminum Hydrochloricum 30C Homeopathic Medicine For Indoor Or Outdoor Allergy Relief, Hay Fever, and Hives - 3 Count (240 Pellets)
- Homeopathic medicine that relieves Allergy symptoms
- Take at the First Sign of Symptoms
- Non-Drowsy, no known side effects, no known drug interactions
- This medicine uses highly diluted natural substances to relieve symptoms.
- This medicine comes in quick-dissolving pellet form
$11.95
Allegra Hives Non-Drowsy Antihistamine Tablets, 5-Count, 24HR Hives Reduction & Itch Relief, 180mg (Pack of 3)
- Includes one (1) 5-count pack of Allegra Hives Non-Drowsy Antihistamine Tablets for 24-Hour Hives Relief
- Works from the inside to reduce hives and relieve itching without drowsiness
- Works from the inside to reduce hives and relieve itching without drowsiness
- Allegra Hives is formulated with active ingredient fexofenadine HCI, a non-drowsy antihistamine that won't make you tired
- One tablet is all you need for 24-hour relief from itchy skin and reduced red, bumpy hives
$17.97
SALE
−$8.94
Allegra Adult 24-Hour Allergy Relief Tablets, Non-Drowsy Indoor and Outdoor Allergy Medicine, 180 mg Fexofenadine HCI Antihistamine Pill, 100-Count
- INCLUDES: One (1) 100-count pack of Allegra Adult 24-Hour Allergy Relief Tablets, Non-Drowsy Allergy Medicine
- 24-HOUR RELIEF: One antihistamine pill is all you need for round-the-clock relief from your worst allergy symptoms
- NON-DROWSY: Formulated with active ingredient fexofenadine, a non-drowsy OTC medication with 0% brain interference
- FAST-ACTING: Allegra 24-hour allergy medicine starts working in one hour for fast* relief from sneezing, runny nose, itchy and watery eyes, and itchy nose or throat
- INDOOR & OUTDOOR ALLERGIES: Use Allegra tablets for outdoor and indoor allergens like pollen, ragweed, grass, trees, dust, mold, and pet dander
$35.45
NUVICARE Fexofenadine 180mg 24 Hour - Fexofenadine Hydrochloride 180 mg Antihistamine for Allergy Relief, Hives, Runny Nose, Itching, Compare to Allegra 24 Hour Non Drowsy Allergy Medicine (18 Count)
- NON-DROWSY: COMPARE TO ALLEGRA - Get the same effective allergy relief for indoor & outdoor allergies from this Fexofenadine 24 hour non drowsy antihistamine as you do from name brands. Compare to the active ingredient in popular OTC allergy meds
- GENERIC OTC SYMPTOM RELIEF - Contains fexofenadine hydrochloride 180mg, the same active ingredient found in well-known all day allergy medication. Get powerful over-the-counter relief for symptoms of hay fever, itching, and watery eyes at a generic brand value.
- COLD AND ALLERGY SUPPORT - Unlike a lot of adult allergy medicine, these are non drowsy allergy pills that won't make you tired. Keep allergy relief tablets on hand for allergy symptoms and during other upper respiratory allergies or cold related symptoms.
- EFFECTIVE TREATMENT - These antihistamine non drowsy pills help address hay fever, or upper respiratory allergies or conditions caused by allergens such as pollen, pet dander, and dust. Fexofenadine 180 mg tablets provide fast-acting relief of common allergy symptoms.
- QUALITY ASSURANCE - Nuvicare Fex-Allergy Relief tablets are produced in a facility that adheres to stringent quality and safety standards. Trust Nuvicare for a reliable and effective solution to your allergy needs.
$5.99
Ohm Fexofenadine Antihistamine Indoor Outdoor Allergy Relief 150Tablets - Single Pack
- OHM Fexofenadine Antihistamine Indoor Outdoor Allergy Relief Tablets.
- 24 Hour Allergy Relief
- Allergy Relief of Sneezing, Runny Nose, Itchy Watery Eyes, Itchy Nose or Throat
$19.99
SALE
−$4.30
Benadryl Extra Strength Allergy Relief Medicine, 50 mg Diphenhydramine HCl Antihistamine Tablets for Relief of Allergy Symptoms Due to Hay Fever or Other Upper Respiratory Allergies, 24 ct
- ALLERGY RELIEF MEDICIATION: 24-count pack of Benadryl Extra Strength Antihistamine Allergy Relief Tablets each containing 50 mg of the antihistamine diphenhydramine hydrochloride for powerful allergy symptom relief
- EXTRA STRENGTH SYMPTOM RELIEF: The allergy medicine provides relief from both indoor & outdoor allergy symptoms such as runny nose, sneezing, itchy, watery eyes, & itchy nose & throat. They also provide symptom relief for hay fever & the common cold
- POWERFUL ANTIHISTAMINE: Formulated with 50 mg diphenhydramine HCl, the extra strength allergy tablets provide relief from hay fever or other upper respiratory allergy symptoms & cold symptoms such as sneezing & runny nose
- FAST & EFFECTIVE: Benadryl Extra Strength Allergy Medicine in small, convenient antihistamine tablets provide effective allergy relief when you need it. Allergy medicine for multi-symptom relief is intended to be used by adults & children ages 12+
- POWERFUL ALLERGY & COLD RELIEF IN JUST 1 PILL: Adults & children over 12 years of age, take one Benadryl Extra Strength Allergy Relief tablet every 4 to 6 hours, or as directed by a doctor, do not take more than 6 times in 24 hours
$8.17
SALE
−$6.35
Benadryl Ultratabs Antihistamine Allergy Relief Medicine, Diphenhydramine HCl Tablets For Relief of Cold & Allergy Symptoms Such as Sneezing, Runny Nose, & Itchy Eyes & Throat, 100 ct
- ALLERGY MEDICATION: Benadryl Allergy Tablets for allergy relief helps to alleviate symptoms associated with allergies such as sneezing, runny nose, itchy throat or nose, and itchy/watery eyes; Powerful allergy and cold relief in just 1 pill
- ANTIHISTAMINE: Allergy medication that temporarily provides allergy & cold relief for hay fever and other upper respiratory symptoms such as sneezing and runny nose; Relief from common allergens such as tree pollen, dust, mold and pet dander.
- COLD SYMPTOM RELIEF: Allergy antihistamine with diphenhydramine is formulated to help relieve multi-symptom allergy relief and cold symptom relief; Effective and powerful formula that works when you need it most
- DIPHENHYDRAMINE FORMULA: Benadryl allergy medicine contains 25 mg of diphenhydramine HCl, an antihistamine that works to help provide allergy and upper respiratory relief.
- INCLUDES: Pack of 1, 100 ct allergy and cold relief medicine; Suitable for adults and children ages 6+; Safe and effective doctor-recommended allergy medicine
$13.39
Last update on 2025-05-03 / Affiliate links / Images from Amazon Product Advertising API