Antihistamine for cough are essential for alleviating symptoms associated with allergies and colds, providing relief from persistent coughing. In 2025, the market offers a variety of effective antihistamines that not only suppress cough but also address other allergy-related symptoms. These medications vary in their active ingredients, formulations, and side effects, making it crucial to choose the right one for your needs. From non-drowsy options to those that promote restful sleep, the best antihistamines can significantly improve your quality of life during allergy season or when battling a cold.
Children’s Dimetapp Fast-Acting Chewable Cough & Allergy Medicine, Antihistamine, Cough Suppressant, Grape Flavor, Relieves Cough, Itchy Throat, Sneezing & Runny Nose, 24 Chewable Tablets
- NEW, FAST-ACTING COUGH & ALLERGY CHEWABLE: When cough and allergy symptoms strike, Children’s Dimetapp provides fast relief and iconic great grape flavor, now in a convenient chewable tablet for on-the-go anytime, anywhere cough and allergy relief
- MULTI-SYMPTOM COUGH & ALLERGY RELIEF: A powerful allergy medicine formulated to pack a punch against cough, itchy throat, sneezing, and runny nose due to colds and allergy
- CONVENIENCE AT ITS BEST: Perfect for busy families on the move, these chewable tablets require no water or dosing cup, making them the ideal on-the-go solution for fast relief
- SAFE AND EFFECTIVE FOR KIDS: Formulated for children 6 years of age and older, Children’s Dimetapp chewable tablets with a kid-friendly grape flavor, work to help alleviate children's cough & allergy symptoms so they can start feeling better, faster
- TRUSTED FOR OVER 50 YEARS: Dimetapp, known for its efficacy and safety in treating children’s cough and allergy symptoms, has been the go-to brand for parents for half a century because Dimetapp helps kids feel better, faster
$9.79
SALE
−$1.78
MAJOR Cough and Cold HBP Medicine - Antihistamine and Cough Suppressant for People with High Blood Pressure - Dextromethorphan HBr, Chlorpheniramine Maleate - 16 Tablets (6 Pack)
- COUGH AND COLD MEDICINE: Introducing Major Cough and Cold Medicine, a trusted remedy that helps provide temporary relief from common cold symptoms including cough, runny nose, and sneezing.
- SPECIALLY FORMULATED FOR HBP: The active ingredients in these cough and cold tablets are designed to assist with cold symptoms in those with high blood pressure.
- ACTIVE INGREDIENTS: These cold tablets contain 30g dextromethorphan HBr cough suppressant and 4g chlorpheniramine maleate antihistamine. They are free of gelatin, starch, gluten, and nuts.
- QUALITY FORMULATION: We maintain high standards of care through strict regulatory compliance to deliver carefully formulated, effective cough and cold tablets. With a dextromethorphan and chlorpheniramine formula, our tablets help with relief from common cold symptoms.
- MAJOR PHARMACEUTICALS: At Major Pharmaceuticals, we believe wellness should be accessible to everyone. We pride ourselves on our legacy of delivering quality OTC and vitamin supplements.
$15.25
SALE
−$0.61
Amazon Basic Care Nighttime Cold & Flu Relief Syrup, Pain Reliever, Fever Reducer, Cough Suppressant, Antihistamine, Cherry , 8 fl oz (Pack of 1)
- ACTIVE INGREDIENTS: Active ingredients are Acetaminophen 650 mg, Dextromethorphan HBr 30 mg, and Doxylamine succinate, 12.5 mg. Compare to the active ingredients of Vicks NyQuil Cold & Flu.
- RELIEVES COLD & FLU SYMPTOMS: Amazon Basic Care Nighttime Cold & Flu Relief provides multi-symptom relief by helping with common symptoms such as aches, fever, cough, sneezing and runny nose.
- NIGHTTIME COLD AND FLU RELIEF: Amazon Basic Care Nighttime Cold and Flu Relief relieves cold and flu symptoms so you can rest through the night.
- EFFECTIVE: Acts as a pain reliever, fever reducer, cough suppressant and antihistamine.
- GLUTEN FREE: This product is Gluten Free. Contains 10% ALCOHOL.
$5.68
SALE
−$0.80
MAJOR Cough and Cold HBP Medicine - Antihistamine and Cough Suppressant for People with High Blood Pressure - Dextromethorphan HBr, Chlorpheniramine Maleate - 16 Tablets (1 Pack)
- COUGH AND COLD MEDICINE: Introducing Major Cough and Cold Medicine, a trusted remedy that helps provide temporary relief from common cold symptoms including cough, runny nose, and sneezing.
- SPECIALLY FORMULATED FOR HBP: The active ingredients in these cough and cold tablets are designed to assist with cold symptoms in those with high blood pressure.
- ACTIVE INGREDIENTS: These cold tablets contain 30g dextromethorphan HBr cough suppressant and 4g chlorpheniramine maleate antihistamine. They are free of gelatin, starch, gluten, and nuts.
- QUALITY FORMULATION: We maintain high standards of care through strict regulatory compliance to deliver carefully formulated, effective cough and cold tablets. With a dextromethorphan and chlorpheniramine formula, our tablets help with relief from common cold symptoms.
- MAJOR PHARMACEUTICALS: We pride ourselves on our legacy of delivering quality OTC and vitamin supplements for over 60 years. At Major Pharmaceuticals, we believe wellness should be accessible to everyone, and strive to always be there when you need us most.
$5.48
Coricidin HBP Antihistamine Cough & Cold Suppressant Tablets for People with High Blood Pressure, 16-Count Boxes (Pack of 3)
- The #1 brand that gives powerful cold symptom relief without raising your blood pressure
- Provides fast, powerful cold relief for people with high blood pressure
- Relieves cough, runny nose, and sneezing
- Decongestant free
- Covered by the Bayer HealthCare LLC-Consumer Health 60-Day Satisfaction Guarantee
$29.85
Amazon Basic Care Nighttime Severe Cold, Flu and Cough Suppressant Medicine Powder, Pain Reliever/Fever Reducer, Nasal Decongestant, Antihistamine, Honey Lemon Infused with White Tea Flavors, 6 Count
- ACTIVE INGREDIENTS: The active ingredients in Severe Cold, Flu and Cough are acetaminophen 650 mg, pain reliever/fever reducer; diphenhydramine HCl 25 mg, antihistamine/cough suppressant; phenylephrine HCl 10 mg, nasal decongestant which compares to Theraflu Severe Cold and Cough active ingredients.
- FAST RELIEF: Severe Cold, Flu and Cough offers hot liquid therapy for fast relief of nasal and sinus congestion, cough, runny nose, sneezing, body ache, sore throat pain, headache and fever.
- CONVENIENT PACKETS: Dissolve powder into 8 oz. of hot water and sip while hot for nighttime cold and flu relief. Take every four hours while symptoms persist.
- COMFORTING WARMTH WITH GREAT TASTE: This flu medicine relieves pain with soothing honey lemon infused with white tea flavors.
- ALCOHOL-FREE COLD AND FLU POWDER: This product contains no alcohol or gluten.
$8.08
SALE
−$5.52
Children’s Dimetapp Cold & Cough Medicine, Cough Suppressant, Nasal Decongestant, Antihistamine, Relieves Nasal Congestion, Cough, Itchy, Watery Eyes & Sneezing, Grape Flavor, Alcohol-Free, 8 Fl Oz
- MULTI-SYMPTOM COLD AND COUGH RELIEF: Our kid-friendly formulas are designed to target specific symptoms—so your child gets everything they need, and nothing they don’t; Active ingredients include Brompheniramine Maleate (antihistamine), Dextromethorphan HBr (cough suppressant), and Phenylephrine HCI (nasal decongestant)
- ALCOHOL-FREE, GREAT GRAPE TASTE: Dimetapp’s sweet grape flavor is alcohol-free and yuck-free (so this helps kids take their medicine)
- PHARMACIST RECOMMENDED BRAND: Dimetapp’s products are safe and effective children’s cold medicines formulated to pack a punch against stuffy, runny nose, itchy, watery eyes, sneezing and cough symptoms
- PROVEN RELIEF: For over 50 years, moms have trusted Dimetapp to help their kids feel better, faster
- Dimetapp Cold & Cough is specifically formulated for children aged 6 years and older; Do not use in children under the age of 6 years
$9.47
Children’s Dimetapp Cold & Cough (4 fl. oz., Pack of 3, Grape Flavor), Nasal Decongestant, Antihistamine & Cough Suppressant, Alcohol-Free, Ages 6+
- Includes three 4 fl oz bottles of Children’s Dimetapp Cold & Cough alcohol-free liquid cold medicine, grape flavor
- # 1 Pharmacist recommended brand for children’s cold and cough combinations
- Multi-symptom cold medicine with a nasal decongestant (Phenylephrine HCI) that relieves stuffy nose to restore free breathing through the nose
- Antihistamine (Brompheniramine maleate) temporarily relieves upper respiratory symptoms that can cause runny nose, sneezing and itchy, watery eyes
- A suppressant for kids (Dextromethorphan HBr) that helps control the impulse to cough
$11.75
SALE
−$2.92
MAJOR Cough and Cold HBP Medicine - Antihistamine and Cough Suppressant for People with High Blood Pressure - Dextromethorphan HBr, Chlorpheniramine Maleate - 16 Tablets (12 Pack)
- COUGH AND COLD MEDICINE: Introducing Major Cough and Cold Medicine, a trusted remedy that helps provide temporary relief from common cold symptoms including cough, runny nose, and sneezing.
- SPECIALLY FORMULATED FOR HBP: The active ingredients in these cough and cold tablets are designed to assist with cold symptoms in those with high blood pressure.
- ACTIVE INGREDIENTS: These cold tablets contain 30g dextromethorphan HBr cough suppressant and 4g chlorpheniramine maleate antihistamine. They are free of gelatin, starch, gluten, and nuts.
- QUALITY FORMULATION: We maintain high standards of care through strict regulatory compliance to deliver carefully formulated, effective cough and cold tablets. With a dextromethorphan and chlorpheniramine formula, our tablets help with relief from common cold symptoms.
- MAJOR PHARMACEUTICALS: At Major Pharmaceuticals, we believe wellness should be accessible to everyone. We pride ourselves on our legacy of delivering quality OTC and vitamin supplements.
$25.42
SALE
−$5.68
Tylenol Cold + Flu Severe Daytime & Nighttime Liquid Cough Medicine with Acetaminophen Pain Reliever & Fever Reducer, Nasal Decongestant & Antihistamine, Value Pack, 2 ct. of 8 fl. oz
- Value pack of Tylenol Cold + Flu + Cough Severe Liquid Medicine containing one 8-fluid ounce bottle of non-drowsy daytime relief medicine and one 8-fluid ounce bottle of nighttime relief medicine
- The daytime flu relief for adults features a powerful non-drowsy formula to keep you going through waking hours with a warming honey lemon flavor. The nighttime liquid medicine relieves symptoms to help you sleep and comes in a soothing berry flavor.
- The liquid medicines both provide temporary relief of cold & flu symptoms including fever, cough, nasal & chest congestion, head & body aches & sore throat. They also aid in loosening mucus & thinning bronchial secretions for more productive coughs
- Formulated with acetaminophen for pain relief & fever reduction, phenylephrine HCl nasal decongestant, guaifenesin as an expectorant & dextromethorphan HBr cough suppressant. The nighttime formula also contains doxylamine succinate, an antihistamine
- Temporarily relieve multiple symptoms both day and night with these powerful severe cold, cough, and flu medicines for adults
$13.00
Last update on 2025-05-03 / Affiliate links / Images from Amazon Product Advertising API